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antihypertensive drug (trade name Hytrin) used to treat high blood pressure (同)Hytrin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/11 22:06:05」(JST)

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Terazosin (marketed as Hytrin or Zayasel) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.

It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon.^[1] Sexual side effects are rare, but may include priapism or erectile dysfunction.

References

^ Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList

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1. 前立腺肥大症の内科的治療 medical treatment of benign prostatic hyperplasia
2. 男性における下部尿路症状 lower urinary tract symptoms in men
3. 夜間頻尿：臨床症状、診断、および治療治療 nocturia clinical presentation diagnosis and treatment
4. 降圧剤と脂質 antihypertensive drugs and lipids
5. 男性の尿失禁 urinary incontinence in men

English Journal

[OP.8D.02] FIRST IN MAN TREATMENT OF SEVERE BP VARIABILITY WITH BAROREFLEX ACTIVATION THERAPY.

Lobo MD1, Adeel MY, Wolff CB, Julu PO, Shah M, Collier DM, Saxena M, Floyd C, Brier T, Kapil V, Mukhtar O, Radunovic A, Sutcliffe N, Sharif F.
Journal of hypertension.J Hypertens.2016 Sep;34 Suppl 2:e105. doi: 10.1097/01.hjh.0000491609.58838.67.
OBJECTIVE: Profound BP variability (BPV) is a major cause of cardiovascular morbidity and poor quality of life as there are no optimal pharmacological strategies to help patients. We hypothesised that in a patient with baroreflex dysfunction and preserved efferent baroreflex pathway, carotid sinus s
PMID 27508576

The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers.

Batty M1, Pugh R2, Rathinam I3, Simmonds J4, Walker E5, Forbes A6, Anoopkumar-Dukie S7,8, McDermott CM9, Spencer B10, Christie D11,12, Chess-Williams R13.
International journal of molecular sciences.Int J Mol Sci.2016 Aug 16;17(8). pii: E1339. doi: 10.3390/ijms17081339.
This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagoni
PMID 27537875

Risk factors for intraoperative floppy iris syndrome: a prospective study.

Chatziralli IP1, Peponis V1, Parikakis E1, Maniatea A1, Patsea E1, Mitropoulos P1; Medscape.
Eye (London, England).Eye (Lond).2016 Aug;30(8):1039-44. doi: 10.1038/eye.2016.122. Epub 2016 Jul 1.
PurposeTo evaluate risk factors for intraoperative floppy iris syndrome (IFIS) in patients undergoing phacoemulsification.MethodsParticipants in the study were 1274 consecutive patients, who underwent routine phacoemulsification cataract surgery. The following data were recorded and evaluated as pos
PMID 27367744

Japanese Journal

Comparison of 7 α1-adrenoceptor Antagonists in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia:A Short-term Crossover Study

Araki Tohru,Monden Koichi,Araki Motoo
Acta Medica Okayama 67(4), 245-251, 2013-08-00
… Seven agents were utilized:tamsulosin 0.2mg, silodosin 8mg, urapidil 60mg, naftopidil 50mg, prazosin 1mg, terazosin 2mg, and doxazosin 1mg. … The agent rankings were doxazosin (25 [22%]), silodosin (22 [19%]), urapidil (19 [17%]), naftopidil (17 [15%]), terazosin (12 [11%]), tamsulosin (11 [10%]), prazosin (7 [6%]). …
NAID 120005315586

Tamsulosin Potently and Selectively Antagonizes Human Recombinant .ALPHA.1A/1D-Adrenoceptors: Slow Dissociation from the .ALPHA.1A-Adrenoceptor May Account for Selectivity for .ALPHA.1A-Adrenoceptor over .ALPHA.1B-Adrenoceptor Subtype

Sato Shuichi,Hatanaka Toshiki,Yuyama Hironori [他],Ukai Masashi,Noguchi Yukiko,Ohtake Akiyoshi,Taguchi Katsunari,Sasamata Masao,Miyata Keiji
Biological and Pharmaceutical Bulletin 35(1), 72-77, 2012
… We determined the binding affinity of tamsulosin, a selective α1-adrenoceptor antagonist, for human α1-adrenoceptor subtypes in comparison with those of other α1-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. …
NAID 130001872345

The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction : α-Blockers in the Treatment of Male Voiding Dysfunction-How Do They Work and Why Do They Differ in Tolerability?

Michel Martin C.
Journal of pharmacological sciences 112(2), 151-157, 2010-02-20
NAID 10029888675

Related Pictures

★リンクテーブル★

リンク元	「テラゾシン」
拡張検索	「terazosin hydrochloride」

「テラゾシン」

Terazosin
Systematic (IUPAC) name
	(RS)-6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
Clinical data
Trade names	Hytrin
AHFS/Drugs.com	monograph
MedlinePlus	a693046
Legal status	US: RX-Only;
Pharmacokinetic data
Protein binding	90-94%
Half-life	12 hours
Identifiers
CAS number	63590-64-7
ATC code	G04CA03
PubChem	CID 5401
DrugBank	DB01162
ChemSpider	5208
UNII	8L5014XET7
KEGG	D08569
ChEBI	CHEBI:9445
ChEMBL	CHEMBL611
Synonyms	[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone
Chemical data
Formula	C19H25N5O4
Molecular mass	387.433 g/mol
	SMILES O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)C4OCCC4;
	InChI InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22) ; Key:VCKUSRYTPJJLNI-UHFFFAOYSA-N ;
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