English Journal

In vitro modeling of hyperpigmentation associated to neurofibromatosis type 1 using melanocytes derived from human embryonic stem cells.

Allouche J1, Bellon N2, Saidani M3, Stanchina-Chatrousse L3, Masson Y3, Patwardhan A4, Gilles-Marsens F4, Delevoye C5, Domingues S3, Nissan X3, Martinat C1, Lemaitre G1, Peschanski M1, Baldeschi C6.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Jul 21;112(29):9034-9. doi: 10.1073/pnas.1501032112. Epub 2015 Jul 6.
"Café-au-lait" macules (CALMs) and overall skin hyperpigmentation are early hallmarks of neurofibromatosis type 1 (NF1). One of the most frequent monogenic diseases, NF1 has subsequently been characterized with numerous benign Schwann cell-derived tumors. It is well established that neurofibromin,
PMID 26150484

Associations of common copy number variants in glutathione S-transferase mu 1 and D-dopachrome tautomerase-like protein genes with risk of schizophrenia in a Japanese population.

Nakamura T1, Ohnuma T1, Hanzawa R1, Takebayashi Y1, Takeda M1, Nishimon S1, Sannohe T1, Katsuta N1, Higashiyama R1, Shibata N1, Arai H1.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.Am J Med Genet B Neuropsychiatr Genet.2015 Jul 14. doi: 10.1002/ajmg.b.32347. [Epub ahead of print]
Oxidative-stress, genetic regions of interest (1p13 and 22q11), and common copy number variations (CNVs) may play roles in the pathophysiology of schizophrenia. In the present study, we confirmed associations between schizophrenia and the common CNVs in the glutathione (GSH)-related genes GSTT1, DDT
PMID 26175060

Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle.

Savkovic V1, Flämig F2, Schneider M1, Sülflow K1, Loth T2, Lohrenz A1, Hacker MC2, Schulz-Siegmund M2, Simon JC3.
Journal of biomedical materials research. Part A.J Biomed Mater Res A.2015 Jun 29. doi: 10.1002/jbm.a.35536. [Epub ahead of print]
Melanocytes differentiated from the stem cells of human hair follicle outer root sheath (ORS) have the potential for developing non-invasive treatments for skin disorders out of a minimal sample: of hair root. With a robust procedure for melanocyte cultivation from the ORS of human hair follicle at
PMID 26126647