タラポルフィン。タラポルフィンナトリウム
WordNet
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
PrepTutorEJDIC
- ソジウム,ナトリウム(金属元素;化学記号はNa)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/14 00:03:50」(JST)
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Talaporfin
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| Systematic (IUPAC) name |
| N-{[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-12-ethyl-2,8,13,18-tetramethyl-17-vinyl-2,3-dihydroporphyrin-5-yl]acetyl}-L-aspartic acid |
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
|
Legal status
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|
|
Routes of
administration
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IV |
| Identifiers |
|
CAS Registry Number
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110230-98-3 Y
220201-34-3 (sodium salt) |
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ATC code
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None |
| PubChem |
CID: 5486799 |
| ChemSpider |
16737134 N |
| UNII |
P4ROX5ELT2 Y |
| Chemical data |
| Formula |
C38H41N5O9 |
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Molecular mass
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711.76 g/mol |
SMILES
- CCC1=C2C=C3C(=C(C(=N3)C(=C4[C@H]([C@@H](C(=N4)C=C5C(=C(C(=CC(=C1C)N2)N5)C=C)C)C)CCC(=O)O)CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O)C
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InChI
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InChI=1S/C38H41N5O9/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24/h7,12-14,18,22,30,39,43H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52)/b24-12-,25-13-,26-12-,27-14-,28-13-,29-14-,35-23-,36-23-/t18-,22-,30-/m0/s1 N
Key:VSEIDZLLWQQJGK-WSUYNKMOSA-N N
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| N (what is this?) (verify) |
Talaporfin (INN, also known as aspartyl chlorin, mono-L-aspartyl chlorin e6, NPe6, or LS11) is a photosensitizer used in photodynamic therapy (PDT).
It absorbs red light at 664 nm normally provided by a laser tuned to this wavelength.[1]
It was approved in Japan (in 2004) for PDT of lung cancer and marketed as Laserphyrin.[2]
It is trademarked as Aptocine by Light Sciences Oncology.[3]
References
- ^ http://journals.lww.com/jto/Fulltext/2006/06000/Photodynamic_Therapy__PDT__for_Lung_Cancers.18.aspx "Photodynamic Therapy (PDT) for Lung Cancers" 2006
- ^ http://meeting.ascopubs.org/cgi/content/abstract/24/18_suppl/7229 "Photodynamic therapy using Laserphyrin for centrally located early stage lung cancer" 2006
- ^ http://www.lsoncology.com/aptocine
UpToDate Contents
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English Journal
- Photodynamic therapy in combination with talaporfin sodium induces mitochondrial apoptotic cell death accompanied with necrosis in glioma cells.
- Miki Y, Akimoto J, Yokoyama S, Homma T, Tsutsumi M, Haraoka J, Hirano K, Beppu M.SourceSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432–1 Horinouchi, Hachioji, Tokyo 92–0392, Japan. miki@ps.toyaku.ac.jp
- Biological & pharmaceutical bulletin.Biol Pharm Bull.2013;36(2):215-21. Epub 2012 Nov 29.
- Photodynamic therapy (PDT) induces selective cell death of neoplastic tissue and connecting vasculature by combining photosensitizers with light. Here we clarified the types of cell death induced by PDT in combination with the photosensitizer talaporfin sodium (mono-L-aspartyl chlorine e6, NPe6) in
- PMID 23196427
- Photodynamic therapy using talaporfin sodium (Laserphyrin®) for bile duct carcinoma: a preliminary clinical trial.
- Nanashima A, Abo T, Nonaka T, Nonaka Y, Morisaki T, Uehara R, Ohnita K, Fukuda D, Murakami G, Tou K, Kunizaki M, Hidaka S, Tsuchiya T, Takeshita H, Nakao K, Nagayasu T.SourceDivision of Surgical Oncology and Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. a-nanasm@nagasaki-u.ac.jp
- Anticancer research.Anticancer Res.2012 Nov;32(11):4931-8.
- The efficacy of adjuvant photodynamic therapy (PDT) using the new photosensitizer, talaporfin sodium (TPS), was assessed in 7 patients with bile duct carcinoma (BDC). The 664-nm semiconductor laser (100 J/cm(2)) was applied through endoscopy to the tumor lesion within 6 h after injection of TPS. Cas
- PMID 23155262
- ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage.
- Kessel DH, Price M, Reiners JJ Jr.SourceDepartment of Pharmacology, Wayne State University School of Medicine, Detroit, MI, USA. dhkessel@med.wayne.edu
- Autophagy.Autophagy.2012 Sep;8(9):1333-41. doi: 10.4161/auto.20792. Epub 2012 Aug 14.
- Photodynamic therapy (PDT) involves photosensitizing agents that, in the presence of oxygen and light, initiate formation of cytotoxic reactive oxygen species (ROS). PDT commonly induces both apoptosis and autophagy. Previous studies with murine hepatoma 1c1c7 cells indicated that loss of autophagy-
- PMID 22889762
Japanese Journal
- Talaporfin sodium を用いた蛍光診断法の可能性と限界
- 丸山 隆志,村垣 善浩,安藤 岳洋,伊関 洋,佐久間 一郎,高倉 公朋,岡田 芳和
- 日本レーザー医学会誌 = The Journal of Japan Society for Laser Medicine 32(2), 139-142, 2011-08-31
- NAID 10029678294
- 脳腫瘍の外科療法 光線力学的治療 (新時代の脳腫瘍学--診断・治療の最前線) -- (脳腫瘍の治療)
Related Links
- Light Sciences Oncology (LSO) is developing Aptocine™ (talaporfin sodium) for solid tumors as well as other indications such as BPH. Aptocine is a water- soluble drug targeted by a small, single-use, disposable drug activator included with ...
- Talaporfin sodium. Wang S, Bromley E, Xu L, Chen JC, Keltner L. Light Sciences Oncology, 15405 SE 37th Street, Suite 100, Bellevue, WA 98006, USA. syshiw@ lsoncology.com. IMPORTANCE OF THE FIELD: Despite therapeutic advances, ...
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