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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/10 21:24:09」(JST)

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Talaporfin (INN, also known as aspartyl chlorin, mono-L-aspartyl chlorine e6, NPe6, or LS11) is a photosensitizer used in photodynamic therapy (PDT).

It absorbs red light at 664nm normally provided by a laser tuned to this wavelength.^[1]

It was approved in Japan (in 2004) for PDT of lung cancer and marketed as Laserphyrin.^[2]

It is trademarked as Aptocine by Light Sciences Oncology.^[3]

References

^ http://journals.lww.com/jto/Fulltext/2006/06000/Photodynamic_Therapy__PDT__for_Lung_Cancers.18.aspx "Photodynamic Therapy (PDT) for Lung Cancers" 2006
^ http://meeting.ascopubs.org/cgi/content/abstract/24/18_suppl/7229 "Photodynamic therapy using Laserphyrin for centrally located early stage lung cancer" 2006
^ http://www.lsoncology.com/aptocine

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

English Journal

Surface layer-preserving photodynamic therapy (SPPDT) in a subcutaneous mouse model of lung cancer.

Kawakubo M, Eguchi K, Arai T, Kobayashi K, Hamblin MR.SourceDepartment of Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan. masayoshikaw@aol.com.
Lasers in surgery and medicine.Lasers Surg Med.2012 Jun 29. doi: 10.1002/lsm.22046. [Epub ahead of print]
BACKGROUND AND OBJECTIVES: Photodynamic therapy (PDT) may be a less invasive treatment for lung cancer. Our newly developed surface layer-preserving PDT (SPPDT) technique enables us to irradiate deep tumor while preserving the overlying tissue. The aim of this basic study was to verify that the SPPD
PMID 22752880

Preliminary clinical report on safety and efficacy of photodynamic therapy using talaporfin sodium for malignant gliomas.

Akimoto J, Haraoka J, Aizawa K.SourceDepartment of Neurosurgery, Tokyo Medical University, Japan. jakimoto@tokyo-med.ac.jp
Photodiagnosis and photodynamic therapy.Photodiagnosis Photodyn Ther.2012 Jun;9(2):91-9. Epub 2012 Feb 28.
OBJECTIVES: To investigate the safety and efficacy of photodynamic therapy (PDT) using talaporfin sodium in patients with surgically, completely unresectable malignant gliomas with invasion into the eloquent areas of the brain associated with language and motor functions.MATERIALS AND METHODS: Subje
PMID 22594978

Japanese Journal

光感受性物質 Talaporfin の細胞への取り込みと光化学反応の画像解析

白銀玲,関口慎太郎,李黎明,南谷晴之
バイオイメージング 20(2), 173-174, 2011-08-10
NAID 10029276948

OP-011-2 胃癌腹膜播種にたいするtalaporfinを用いた光線力学治療(PDT)の基礎的検討(胃癌-2,一般口演,第110回日本外科学会定期学術集会)

岸健太郎,矢野雅彦,井上正宏,宮代勲,本告正明,田中晃司,真貝竜史,後藤邦仁,高橋秀典,能浦真吾,山田晃正,大植雅之,大東弘明,石川治
日本外科学会雑誌 111(臨時増刊号_2), 314, 2010-03-05
NAID 110007715890

細胞形態の違いによる光線力学療法効果の違いの検討

酒井真理,櫛引俊宏,粟津邦男
日本レーザー医学会誌 = The Journal of Japan Society for Laser Medicine 30(4), 405-414, 2010-01-30
NAID 10026089063

Related Pictures

Rapid and Simple Analysis of N -Aspartylchlor in E6 (Talaporfin) Using Fluorescence The fluorescence intensity of talaporfin sodium in cultured ESCC cells | Download Pronounce Medical Words ― Talaporfin Sodium - YouTube Hematoxylin and eosin-stained slides of normal, and TS-mediated PDT | Download Rapid and Simple Analysis of N -Aspartylchlor in E6 (Talaporfin) Using Fluorescence 注射用レザフィリン100mgの添付文書 - 医薬情報QLifePro

★リンクテーブル★

リンク元	「タラポルフィン」
拡張検索	「talaporfin sodium」

「タラポルフィン」

Talaporfin
Systematic (IUPAC) name
	N-{[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-12-ethyl-2,8,13,18-tetramethyl-17-vinyl-2,3-dihydroporphyrin-5-yl]acetyl}-L-aspartic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	IV
Identifiers
CAS number	110230-98-3; 220201-34-3 (sodium salt)
ATC code	None
PubChem	CID 5486799
UNII	P4ROX5ELT2
Chemical data
Formula	C38H41N5O9
Mol. mass	711.76 g/mol
SMILES	eMolecules & PubChem
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