syngeneic

• adj.

• 同一遺伝子の、同系の、同系間の、同系内の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/08/20 01:36:10」(JST)

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The word "syngenic" or "syngeneic" (from the Greek word for a relative) means genetically identical, or sufficiently identical and immunologically compatible as to allow for transplantation. For example, it may be used for something transplanted from an identical twin. When the cells are collected from the same patient on whom they will be used, it is called autologous and when collected from identical individuals, it is referred to as syngeneic. A syngeneic graft is known as an isograft.

It is contrasted with Autotransplantation (from one part of the body to another in the same person), allotransplantation (from other individual of same species), and xenotransplantation (from other species).

A tumor isolated from an organism and transplanted in its syngeneic organism elicits an immune reaction leading to rejection, whereas a normal transplanted tissue won't. This signifies that tumor cells show antigens which are completely new or modified. This forms the basis of Tumor Specific Transplantation Antigens(TSTA) or Tumor Associated Transplant Antigens(TATA).

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• 1. 多発性骨髄腫における同種造血細胞移植 allogeneic hematopoietic cell transplantation in multiple myeloma
• 2. 成人の再生不良性貧血における造血細胞移植 hematopoietic cell transplantation for aplastic anemia in adults
• 3. 慢性骨髄性白血病における造血細胞移植 hematopoietic cell transplantation in chronic myeloid leukemia
• 4. 輸血合併症の予防のための白血球除去 leukoreduction to prevent complications of blood transfusion
• 5. 造血細胞移植後生存者へのアプローチ the approach to hematopoietic cell transplantation survivorship

English Journal

• Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors.

• Glowa C1, Karger CP2, Brons S3, Zhao D4, Mason RP4, Huber PE5, Debus J6, Peschke P7.
• Cancer letters.Cancer Lett.2016 Aug 10;378(2):97-103. doi: 10.1016/j.canlet.2016.05.013. Epub 2016 May 17.
• OBJECTIVE: To quantitatively study the impact of intrinsic tumor characteristics and microenvironmental factors on local tumor control after irradiation with carbon ((12)C-) ions and photons in an experimental prostate tumor model.MATERIAL AND METHODS: Three sublines of a syngeneic rat prostate tumo
• PMID 27224892

• Resistance of novel mouse strains different in MHC class I and the NKC domain to the development of experimental tumors.

• Fišerová A1, Richter J1, Čapková K1, Bieblová J2, Mikyšková R2, Reiniš M2, Indrová M2.
• International journal of oncology.Int J Oncol.2016 Aug;49(2):763-72. doi: 10.3892/ijo.2016.3561. Epub 2016 Jun 3.
• To elucidate the immunological mechanisms critical for tumor progression, we bred novel mouse strains, different in the NKC and H-2D domains. We used inbreeding to generate hybrids of Balb/c and C57BL/6 of stable H-2Db+d-NK1.1neg and H-2Db-d+NK1.1high phenotypes. We analyzed the growth of three esta
• PMID 27279019

• Disruption of Iron Regulation after Radiation and Donor Cell Infusion.

• Karoopongse E1, Marcondes AM2, Yeung C3, Holman Z1, Kowdley KV4, Campbell JS5, Deeg HJ6.
• Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2016 Jul;22(7):1173-81. doi: 10.1016/j.bbmt.2016.03.031. Epub 2016 Apr 7.
• Iron overload is common in patients undergoing hematopoietic cell transplantation (HCT). Peritransplant events, such as total body irradiation (TBI), and the effects of donor cell infusion may contribute to iron overload, in addition to disease-associated anemia and RBC transfusions. Using murine mo
• PMID 27060441

Japanese Journal

• Fas-Deficient Fully Allogeneic Dendritic Cells Administered Via an Intratumoral Injection Route Show Efficient Antitumor Effects in Murine models

• Okano Shinji,Kondoh Haruhiko,Toshima Takeo,Nakagawara Hidekazu,Yoshizumi Tomoharu,Soejima Yuji,Shirabe Ken,Harada Mamoru,Yoshikai Yasunobu,Maehara Yoshihiko,岡野 慎士,近藤 晴彦,戸島 剛男,中川原 英和,吉住 朋晴,副島 雄二,調 憲,原田 守,吉開 泰信,前原 喜彦,オカノ シンジ,コンドウ ハルヒコ,トシマ タケオ,ナカガワラ ヒデカズ,ヨシズミ トモハル,ソエジマ ユウジ,シラベ ケン,ハラダ マモル,ヨシカイ ヤスノブ,マエハラ ヨシヒコ
• 福岡医学雑誌 104(1), 15-26, 2013-01-25
• … In this study, we found that the injection of Fas-deficient fully allogeneic DCs via an intratumoral injection route exerted efficient antitumor effects, as did syngeneic DCs, but wild-type fully allogeneic DCs did not. …
• NAID 120005227184

• The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis

• Lavrnja Irena,Savic Danijela,Bjelobaba Ivana [他],DACIC Sanja,BOZIC Iva,PARABUCKI Ana,NEDELJKOVIC Nadezda,PEKOVIC Sanja,RAKIC Ljubisav,STOJILJKOVIC Mirjana
• Journal of pharmacological sciences 119(3), 221-232, 2012-07-20
• … EAE was induced in genetically susceptible Dark Agouti rats with syngeneic spinal cord homogenate in complete Freund's adjuvant. …
• NAID 10030986853

• Postinflammation stage of autoimmune orchitis induced by immunization with syngeneic testicular germ cells alone in mice

• NAITO Munekazu,HIRAI Shuichi,TERAYAMA Hayato,QU Ning,KUERBAN Maimaiti,MUSHA Muhetaerjiang,KITAOKA Miyuki,OGAWA Yuki,ITOH Masahiro
• Medical molecular morphology : official journal of the Japanese Society for Clinical Molecular Morphology 45(1), 35-44, 2012-03-01
• NAID 10030573640

Related Links

• Syngeneic | definition of syngeneic by Medical dictionary

syngeneic [sin″jĕ-ne´ik] in transplantation biology, denoting individuals or tissues having identical genotypes, i.e., identical twins or animals of the same inbred strain, or their tissues. Called also isogeneic and isologous. syn·ge·ne·ic (sin'jĕ-nē'ik

• Syngeneic - definition of syngeneic by The Free Dictionary

syn·ge·ne·ic (sĭn′jə-nē′ĭk) adj. Genetically identical or closely related, so as to allow tissue transplant; immunologically compatible: syngeneic grafts; syngeneic mice. [From Greek sungeneia, kinship: syn-, syn-+ genos, family; see genə ...

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リンク元	「同系」「同系内」「同系間」「同一遺伝子」
拡張検索	「syngeneic transplantation」

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同系、同系間、同一遺伝子

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isograft