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English Journal

Chemical sympathectomy alters the development of hypertension in miniature swine.

Thomas GD1, O'Hagan KP, Zambraski EJ.
Hypertension.Hypertension.1991 Mar;17(3):357-62.
To determine if the neurotoxin 6-hydroxydopamine could be used to chemically sympathectomize neonatal miniature swine, eight newborn swine were treated with 6-hydroxydopamine beginning on the first day after birth and continuing at regular intervals for the next 6 months. Six littermates served as c
PMID 1900258

Thomas GD1, O'Hagan KP, Zambraski EJ.
Clinical and experimental hypertension. Part A, Theory and practice.Clin Exp Hypertens A.1990;12(4):647-61.
To validate a miniature swine model of sympathectomy, six swine that had chronic high blood pressures for unknown reasons and five DOCA hypertensive swine were treated with a single dose of the neurotoxin 6-hydroxydopamine (6-OHDA) (50 mg/kg i.v.). One week after 6-OHDA, conscious mean arterial pres
PMID 2114951

Differential effects of surgical sympathectomy on rat heart concentrations of neuropeptide Y-immunoreactivity and noradrenaline.

Maccarrone C1, Jarrott B.
Journal of the autonomic nervous system.J Auton Nerv Syst.1987 Dec;21(2-3):101-7.
The aim of this study was to estimate the proportion of cardiac neuropeptide Y-immunoreactivity (NPY-ir) which is not present in sympathetic neurones innervating the rat heart. The procedure employed was to surgically sympathectomize the heart and then measure the remaining cardiac concentrations of
PMID 3450689