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- SULTs
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- SULTs
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/08 10:10:10」(JST)
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The structure and bonding of the sulfate ion
Sulfotransferases EC 2.8.2.- are transferase enzymes that catalyze the transfer of a sulfo group (not a sulfate group) from a donor molecule to an acceptor alcohol or amine.[1] The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R-OSO3−), whereas an amine leads to a sulfo-amine (R-NH-SO3−). Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.[2]
Contents
- 1 Examples
- 2 See also
- 3 References
- 4 External links
Examples
The following are examples of sulfotransferases:
- carbohydrate sulfotransferase: CHST1, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9, CHST10, CHST11, CHST12, CHST13, CHST14
- galactose-3-O-sulfotransferase: GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4
- heparan sulfate 2-O-sulfotransferase: HS2ST1,
- heparan sulfate 3-O-sulfotransferase: HS3ST1, HS3ST2, HS3ST3A1, HS3ST3A2, HS3ST3B1, HS3ST3B2, HS3ST4, HS3ST5, HS3ST6
- heparan sulfate 6-O-sulfotransferase: HS6ST1, HS6ST2, HS6ST3
- N-deacetylase/N-sulfotransferase: NDST1, NDST2, NDST3, NDST4
- tyrosylprotein sulfotransferase: TPST1, TPST2
- uronyl-2-sulfotransferase
- Estrone sulfotransferase
- Chondroitin 4-sulfotransferase
- other: SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1B1, SULT1C2, SULT1C3, SULT1C4, SULT1D1P, SULT1E1, SULT2A1, SULT2B1, SULT4A1, SULT6B1
See also
- List of EC numbers_(EC_2)#EC_2.8.2: Sulfotransferases
- Wikipedia:MeSH_D08#MeSH_D08.811.913.817_---_sulfur_group_transferases_.28EC_2.8.29
References
- ^ Negishi M, Pedersen LG, Petrotchenko E, et al. (2001). "Structure and function of sulfotransferases". Arch. Biochem. Biophys. 390 (2): 149–57. doi:10.1006/abbi.2001.2368. PMID 11396917.
- ^ Rath VL, Verdugo D, Hemmerich S (2004). "Sulfotransferase structural biology and inhibitor discovery". Drug Discov. Today 9 (23): 1003–11. doi:10.1016/S1359-6446(04)03273-8. PMID 15574316.
External links
- Sulfotransferases at the US National Library of Medicine Medical Subject Headings (MeSH)
Transferases: sulfur-containing group (EC 2.8)
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2.8.1: Sulfurtransferases |
- Thiosulfate sulfurtransferase
- 3-mercaptopyruvate sulfurtransferase
- thiosulfate—thiol sulfurtransferase
- tRNA sulfurtransferase
- thiosulfate—dithiol sulfurtransferase
- biotin synthase
- cysteine desulfurase
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2.8.2: Sulfotransferases |
- Alcohol sulfotransferase
- Tyrosylprotein sulfotransferase
- Aryl sulfotransferase
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2.8.3: CoA-transferases |
- Propionate CoA-transferase
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2.8.4: Alkylthio |
- Coenzyme-B sulfoethylthiotransferase
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Proteins: enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Whole-cell-dependent biosynthesis of sulfo-conjugate using human sulfotransferase expressing budding yeast.
- Nishikawa M1,2, Masuyama Y2, Nunome M2, Yasuda K2, Sakaki T2, Ikushiro S3.
- Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2017 Nov 13. doi: 10.1007/s00253-017-8621-x. [Epub ahead of print]
- PMID 29134333
- Generation and Characterization of SULT4A1 Mutant Mouse Models.
- Garcia PL1, Hossain MI1, Andrabi SA1, Falany CN2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2017 Nov 6. pii: dmd.117.077560. doi: 10.1124/dmd.117.077560. [Epub ahead of print]
- PMID 29109113
- Efficiency of the sulfate pathway in comparison to the Δ4- and Δ5-pathway of steroidogenesis in the porcine testis.
- Klymiuk MC1, Neunzig J2, Bernhardt R2, Sánchez-Guijo A3, Hartmann MF3, Wudy SA3, Schuler G4.
- The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2017 Nov 6. pii: S0960-0760(17)30303-5. doi: 10.1016/j.jsbmb.2017.10.017. [Epub ahead of print]
- PMID 29107177
Japanese Journal
- Sulfation of ractopamine and salbutamol by the human cytosolic sulfotransferases
- Ko KyoungA,Kurogi Katsuhisa,Davidson Garrett 他
- Journal of Biochemistry 152(3), 275-283, 2012-09-00
- NAID 40019415258
- Ethanol Sulfation by the Human Cytosolic Sulfotransferases: A Systematic Analysis
- Kurogi Katsuhisa,Davidson Garrett,Mohammed Yasir Ihsan,Williams Frederick Edward,Liu Ming-Yih,Sakakibara Yoichi,Suiko Masahito,Liu Ming-Cheh
- Biological and Pharmaceutical Bulletin 35(12), 2180-2185, 2012
- Ethyl sulfate, a minor and direct ethanol metabolite in adult human body, has been implicated as a biomarker for alcohol consumption and in utero exposure to ethanol. To understand better the physiolo …
- NAID 130002480508
- Enzymatic Sulfation of Tocopherols and Tocopherol Metabolites by Human Cytosolic Sulfotransferases
- HASHIGUCHI Takuyu,KUROGI Katsuhisa,SAKAKIBARA Yoichi,YAMASAKI Masao,NISHIYAMA Kazuo,YASUDA Shin,LIU Ming-Cheh,SUIKO Masahito
- Bioscience, biotechnology, and biochemistry 75(10), 1951-1956, 2011-10-23
- … To gain insight into the enzymatic sulfation of tocopherols and their metabolites, a systematic investigation was performed using all 14 known human cytosolic sulfotransferases (SULTs). …
- NAID 10029872846
Related Links
- Sulfotransferases EC 2.8.2. are transferase enzymes that catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The most common sulfate donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS).
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