スルファメトキシジアジン
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- sulfameter
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/04 15:26:48」(JST)
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Sulfametoxydiazine
|
| Systematic (IUPAC) name |
| 4-amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide |
| Clinical data |
| Legal status |
? |
| Identifiers |
| CAS number |
651-06-9 N |
| ATC code |
J01ED04 |
| PubChem |
CID 5326 |
| ChemSpider |
5135 Y |
| UNII |
3L179F09D6 Y |
| KEGG |
D02517 Y |
| ChEBI |
CHEBI:53727 Y |
| ChEMBL |
CHEMBL1200359 N |
| NIAID ChemDB |
008164 |
| Chemical data |
| Formula |
C11H12N4O3S |
| Mol. mass |
280.303 g/mol |
SMILES
- O=S(=O)(Nc1ncc(OC)cn1)c2ccc(N)cc2
|
InChI
-
InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) Y
Key:GPTONYMQFTZPKC-UHFFFAOYSA-N Y
|
| N (what is this?) (verify) |
Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.
|
Antibacterials: nucleic acid inhibitors (J01E, J01M)
|
|
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
| DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Trimethoprim#
- Brodimoprim
- Tetroxoprim
- Iclaprim†
|
|
Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
|
|
Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
|
|
Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
|
|
| Other/ungrouped |
- Sulfacetamide
- Sulfadicramide
- Sulfametrole
|
|
|
| Combinations |
- Trimethoprim/sulfamethoxazole#
|
|
|
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
| 1st g. |
- Cinoxacin‡
- Flumequine
- Nalidixic acid
- Oxolinic acid
- Pipemidic acid
- Piromidic acid
- Rosoxacin
|
|
Fluoro-
quinolones |
| 2nd g. |
- Ciprofloxacin#
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin
- Nadifloxacin
- Ofloxacin
- Norfloxacin
- Pefloxacin
- Rufloxacin
|
|
| 3rd g. |
- Balofloxacin
- Grepafloxacin‡
- Levofloxacin
- Pazufloxacin
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin
|
|
| 4th g. |
- Besifloxacin
- Clinafloxacin†
- Garenoxacin
- Gemifloxacin
- Moxifloxacin
- Gatifloxacin‡
- Sitafloxacin
- Trovafloxacin‡/Alatrofloxacin‡
- Prulifloxacin
|
|
| Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
|
|
| Related (DG) |
- Aminocoumarins: Novobiocin
|
|
|
|
Anaerobic DNA
inhibitors |
| Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
|
|
| Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
|
|
|
| RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifaximin
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
gr+f/gr+a (t)/gr-p (c)/gr-o
|
drug (J1p, w, n, m, vacc)
|
|
|
|
|
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
|
|
| Nucleic acid inhibitor |
|
Rifamycins/
RNA polymerase inhibitor
|
- Rifampicin#
- Rifabutin
- Rifapentine
|
|
|
Antifolates/DSI
|
- Dapsone#
- Acedapsone
- Aldesulfone sodium
|
|
|
ASA
|
- 4-Aminosalicylic acid# (Calcium aminosalicylate
- Sodium aminosalicylate)
|
|
|
| Protein synthesis inhibitor |
|
Aminoglycosides
|
- Amikacin#
- Capreomycin#
- Kanamycin#
- Streptomycin#
|
|
|
Oxazolidone
|
|
|
|
| Cell envelope antibiotic |
|
Peptidoglycan layer
|
- Alanine analogue: Cycloserine#
|
|
|
Arabinogalactan layer
|
- Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol#
SQ109†
|
|
|
Mycolic acid layer
|
- Hydrazides/mycolic acid synth. inhibition: Isoniazid#
- Thiocarbamides: Ethionamide#
- Prothionamide
- Thiocarlide
|
|
|
| Other/unknown |
- Phenazine (Clofazimine)#
- Pyrazine (Pyrazinamide#, Morinamide)
- Isoxazole (Terizidone)
- Bedaquiline
- Metronidazole (delamanid)
|
|
| Combinations |
- Rifampicin/isoniazid/pyrazinamide
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
gr+f/gr+a (t)/gr-p (c)/gr-o
|
drug (J1p, w, n, m, vacc)
|
|
|
|
English Journal
- Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing.
- Dragostin OM1, Samal SK2, Lupascu F3, Pânzariu A4, Dubruel P5, Lupascu D6, Tuchilus C7, Vasile C8, Profire L9.
- International journal of molecular sciences.Int J Mol Sci.2015 Dec 15;16(12):29843-55. doi: 10.3390/ijms161226204.
- The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical propert
- PMID 26694354
- Hirshfeld surface analysis of sulfameter (polymorph III), sulfameter dioxane monosolvate and sulfameter tetrahydrofuran monosolvate, all at 296 K.
- Tailor SM1, Patel UH1.
- Acta crystallographica. Section C, Structural chemistry.Acta Crystallogr C Struct Chem.2015 Nov 1;71(Pt 11):944-53. doi: 10.1107/S2053229615017520. Epub 2015 Oct 13.
- The ability of the antibacterial agent sulfameter (SMT) to form solvates is investigated. The X-ray crystal structures of sulfameter solvates have been determined to be conformational polymorphs. Both 1,4-dioxane and tetrahydrofuran form solvates with sulfameter in a 1:1 molar ratio. 4-Amino-N-(5-me
- PMID 26524165
- Antibiotics, Antibiotic Resistance Genes, and Bacterial Community Composition in Fresh Water Aquaculture Environment in China.
- Xiong W1, Sun Y, Zhang T, Ding X, Li Y, Wang M, Zeng Z.
- Microbial ecology.Microb Ecol.2015 Aug;70(2):425-32. doi: 10.1007/s00248-015-0583-x. Epub 2015 Mar 10.
- Environmental antibiotic resistance has drawn increasing attention due to its great threat to human health. In this study, we investigated concentrations of antibiotics (tetracyclines, sulfonamides and (fluoro)quinolones) and abundances of antibiotic resistance genes (ARGs), including tetracycline r
- PMID 25753824
Related Links
- sulfametoxydiazine (uncountable) Wikipedia has an article on: sulfametoxydiazine Wikipedia A long-acting sulfonamide antibacterial, used as a leprostatic agent and in the treatment of urinary tract infections. Synonyms [] (USAN) ...
- Sulfametoxydiazine File:Sulfametoxydiazine.svg Systematic name 4-amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide Identifiers CAS Number 651-06-9 ATC code J01ED04 PubChem CID: 5326 ChemSpider 5135 UNII C 11 ...
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