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- sulfametoxydiazine
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/10 20:32:52」(JST)
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Sulfametoxydiazine
|
| Systematic (IUPAC) name |
| 4-amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide |
| Clinical data |
| Identifiers |
|
CAS Registry Number
|
651-06-9 N |
|
ATC code
|
J01ED04 |
| PubChem |
CID 5326 |
| ChemSpider |
5135 Y |
| UNII |
3L179F09D6 Y |
| KEGG |
D02517 Y |
| ChEBI |
CHEBI:53727 Y |
| ChEMBL |
CHEMBL1200359 N |
| NIAID ChemDB |
008164 |
| Chemical data |
| Formula |
C11H12N4O3S |
|
Molecular mass
|
280.303 g/mol |
SMILES
- O=S(=O)(Nc1ncc(OC)cn1)c2ccc(N)cc2
|
InChI
-
InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) Y
Key:GPTONYMQFTZPKC-UHFFFAOYSA-N Y
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| N (what is this?) (verify) |
Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.
|
Antibacterials: nucleic acid inhibitors (J01E, J01M)
|
|
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
| DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Trimethoprim#
- Brodimoprim
- Tetroxoprim
- Iclaprim†
|
|
Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
|
|
Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
|
|
Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
|
|
| Other/ungrouped |
- Sulfacetamide
- Sulfadicramide
- Sulfametrole
|
|
|
| Combinations |
- Trimethoprim/sulfamethoxazole#
|
|
|
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
| 1st g. |
- Cinoxacin‡
- Flumequine
- Nalidixic acid
- Oxolinic acid
- Pipemidic acid
- Piromidic acid
- Rosoxacin
|
|
Fluoro-
quinolones |
| 2nd g. |
- Ciprofloxacin#
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin
- Nadifloxacin
- Ofloxacin
- Norfloxacin
- Pefloxacin
- Rufloxacin
|
|
| 3rd g. |
- Balofloxacin
- Grepafloxacin‡
- Levofloxacin
- Pazufloxacin
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin
|
|
| 4th g. |
- Besifloxacin
- Clinafloxacin†
- Garenoxacin
- Gemifloxacin
- Moxifloxacin
- Gatifloxacin‡
- Sitafloxacin
- Trovafloxacin‡/Alatrofloxacin‡
- Prulifloxacin
|
|
| Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
|
|
| Related (DG) |
- Aminocoumarins: Novobiocin
|
|
|
|
Anaerobic DNA
inhibitors |
| Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
|
|
| Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
|
|
|
| RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifaximin
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of bacterial disease
|
|
| Description |
|
|
| Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
|
|
| Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
- Vaccines
|
|
|
|
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
|
|
| Nucleic acid inhibitor |
Rifamycins/
RNA polymerase inhibitor |
- Rifampicin#
- Rifabutin
- Rifapentine
|
|
| Antifolates/DSI |
- Dapsone#
- Acedapsone
- Aldesulfone sodium
|
|
| ASA |
- 4-Aminosalicylic acid# (Calcium aminosalicylate
- Sodium aminosalicylate)
|
|
|
| Protein synthesis inhibitor |
| Aminoglycosides |
- Amikacin#
- Capreomycin#
- Kanamycin#
- Streptomycin#
|
|
| Oxazolidone |
|
|
|
| Cell envelope antibiotic |
| Peptidoglycan layer |
- Alanine analogue: Cycloserine#
|
|
| Arabinogalactan layer |
- Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol#
|
|
| Mycolic acid layer |
- Hydrazides/mycolic acid synth. inhibition: Isoniazid#
- Thiocarbamides: Ethionamide#
- Prothionamide
- Thiocarlide
|
|
|
| Other/unknown |
- Phenazine (Clofazimine)#
- Pyrazine (Pyrazinamide#, Morinamide)
- Isoxazole (Terizidone)
- Bedaquiline
- Metronidazole (delamanid)
|
|
| Combinations |
- Rifampicin/isoniazid/pyrazinamide
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of bacterial disease
|
|
| Description |
|
|
| Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
|
|
| Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
- Vaccines
|
|
|
English Journal
- Occurrence, seasonal variation and risk assessment of antibiotics in the reservoirs in North China.
- Li N1, Zhang X2, Wu W3, Zhao X4.
- Chemosphere.Chemosphere.2014 Sep;111:327-35. doi: 10.1016/j.chemosphere.2014.03.129. Epub 2014 May 13.
- The occurrence and seasonal variability of five groups (tetracycline, quinolone, chloramphenicol, macrolide and sulfonamide) of antibiotics were investigated in the surface water of four reservoirs. The dissolved concentrations of 29 antibiotics were in the ngL(-1) level. Trace levels of all target
- PMID 24997936
- Porous molecularly imprinted monolithic capillary column for on-line extraction coupled to high-performance liquid chromatography for trace analysis of antimicrobials in food samples.
- Zhang Q1, Xiao X2, Li G3.
- Talanta.Talanta.2014 Jun;123:63-70. doi: 10.1016/j.talanta.2014.02.010. Epub 2014 Feb 12.
- A novel porous molecularly imprinted monolithic capillary column (MIMCC) based on ternary porogen was synthesized by in situ technique with sulfaquinoxaline as the template molecule. The characteristics of the MIMCC were investigated by scanning electron microscopy, infrared spectrum, thermogravimet
- PMID 24725865
- Sorption-desorption and transport of trimethoprim and sulfonamide antibiotics in agricultural soil: effect of soil type, dissolved organic matter, and pH.
- Zhang YL1, Lin SS, Dai CM, Shi L, Zhou XF.
- Environmental science and pollution research international.Environ Sci Pollut Res Int.2014 May;21(9):5827-35. doi: 10.1007/s11356-014-2493-8. Epub 2014 Jan 19.
- Use of animal manure is a main source of veterinary pharmaceuticals (VPs) in soil and groundwater through a series of migration processes. The sorption-desorption and transport of four commonly used VPs including trimethoprim (TMP), sulfapyridine, sulfameter, and sulfadimethoxine were investigated i
- PMID 24443047
Related Links
- Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long- acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.
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