スルバクタムナトリウム

関: sulbactam

WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/01 19:03:09」(JST)

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Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics. ^[1]

Mechanism[edit]

Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.

Uses[edit]

Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.

In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

Recently, its use in treating Acinetobacter septicemia is receiving renewed interest.

References[edit]

^ Totir MA, Helfand MS, Carey MP, et al. (August 2007). "Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase". Biochemistry 46 (31): 8980–7. doi:10.1021/bi7006146. PMC 2596720. PMID 17630699.

UpToDate Contents

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1. β-ラクタマーゼ阻害剤、カルバペネム系、およびモノバクタム系抗菌薬の併用 combination beta lactamase inhibitors carbapenems and monobactams
2. アシネトバクター感染：治療および予防 acinetobacter infection treatment and prevention
3. 歯性感染症の合併症、診断、および治療 complications diagnosis and treatment of odontogenic infections
4. β-ラクタム系抗生物質：作用機序、耐性および有害作用 beta lactam antibiotics mechanisms of action and resistance and adverse effects
5. 消化性潰瘍の合併症の概要 overview of the complications of peptic ulcer disease

English Journal

Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance.

Qureshi ZA1, Hittle LE2, O'Hara JA1, Rivera JI1, Syed A1, Shields RK1, Pasculle AW3, Ernst RK2, Doi Y1.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2015 May 1;60(9):1295-303. doi: 10.1093/cid/civ048. Epub 2015 Jan 28.
BACKGROUND: With an increase in the use of colistin methansulfonate (CMS) to treat carbapenem-resistant Acinetobacter baumannii infections, colistin resistance is emerging.METHODS: Patients with infection or colonization due to colistin-resistant A. baumannii were identified at a hospital system in
PMID 25632010

Prevalence and antimicrobial resistance profile of Staphylococcus species in chicken and beef raw meat in egypt.

Osman KM1, Amer AM, Badr JM, Saad AS.
Foodborne pathogens and disease.Foodborne Pathog Dis.2015 May;12(5):406-13. doi: 10.1089/fpd.2014.1882. Epub 2015 Mar 19.
Coagulase-positive (CPS) and coagulase-negative (CNS) staphylococci cause staphylococcal food poisoning. Recently, CPS and CNS have received increasing attention due to their potential role in the dissemination of antibiotic resistance markers. The present study aimed to evaluate CPS and CNS species
PMID 25789407

First Report of NDM-1-Producing Acinetobacter guillouiae.

Bošnjak Z1, Plecko V, Budimir A, Mareković I, Bedenić B.
Chemotherapy.Chemotherapy.2015 Apr 25;60(4):250-252. [Epub ahead of print]
BACKGROUND: Acinetobacter spp. is an opportunistic pathogen that has demonstrated increasing relevance in nosocomial infections. Carbapenem-resistant strains have been reported worldwide.METHODS: Since 2014, screening for metallo-β-lactamases (MBLs) in all Acinetobacter spp. isolates using phenotyp
PMID 25925795

Japanese Journal

症例スルバクタムナトリウム・セフォペラゾンナトリウム(スルペラゾン)による多形滲出性紅斑型薬疹

上原和子,佐藤八千代,福田英嗣 [他]
皮膚科の臨床 50(8), 987-990, 2008-08-00
NAID 40016196413

拡散強調MRI画像が肝嚢胞内の感染巣の同定に有用であった維持透析多発性嚢胞腎患者の1例

小河秀郎,近藤基之,平田邦夫 [他],金崎めぐみ,山田衆,坂本力
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 40(5), 435-440, 2007-05-28
… sulbactam sodium/cefoperazone sodium (SBT/CPZ) を1g/日投与にて症状は軽快し炎症所見も消退した. …
NAID 10019967033

Lung Abscess Caused by Actinomyces odontolyticus

Takiguchi Yasuo,Terano Takashi,Hirai Akira
Internal medicine 42(8), 723-725, 2003-08-01
A 64-year-old woman with periodontal disease was admitted because of fever, right chest pain, and bloody sputum. Her chest radiograph revealed a nodular shadow in the right middle lung fields. From th …
NAID 10011427991

「cefoperazon sodium/sulbactam sodium mixture」

Sulbactam
Systematic (IUPAC) name
	(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a693021
Legal status	POM (UK)
Routes	Injection
Pharmacokinetic data
Bioavailability	1
Excretion	Kidneys?
Identifiers
CAS number	68373-14-8
ATC code	J01CG01
PubChem	CID 130313
ChemSpider	115306
UNII	S4TF6I2330
KEGG	D08533
ChEBI	CHEBI:9321
ChEMBL	CHEMBL403
Chemical data
Formula	C8H11NO5S
Mol. mass	233.243 g/mol
	SMILES O=S2(=O)C([C@@H](N1C(=O)C[C@H]12)C(=O)O)(C)C;
	InChI InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 ; Key:FKENQMMABCRJMK-RITPCOANSA-N ;
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　　[★] セフォペラゾンナトリウム・スルバクタムナトリウム合剤

「sulbactam sodium/cefoperazon sodium mixture」

　　[★] スルバクタムナトリウム・セフォペラゾンナトリウム合剤

「ampicillin sodium/sulbactam sodium mixture」

　　[★] アンピシリンナトリウム・スルバクタムナトリウム合剤

「sulbactam」

　　[★] スルバクタム, SBT

[pmid17630699-1] Totir MA, Helfand MS, Carey MP, et al. (August 2007). "Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase". Biochemistry 46 (31): 8980–7. doi:10.1021/bi7006146. PMC 2596720. PMID 17630699.

拡張検索	「cefoperazon sodium/sulbactam sodium mixture」「sulbactam sodium/cefoperazon sodium mixture」「ampicillin sodium/sulbactam sodium mixture」
関連記事	「sulbactam」

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sulbactam sodium