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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/10 12:59:32」(JST)

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Sulbactam is a beta-lactamase inhibitor. This molecule is given in combination with beta-lactam antibiotics to inhibit beta-lactamase, an enzyme produced by bacteria that destroys the antibiotics. ^[1]

Mechanism[edit]

Sulbactam is an irreversible inhibitor of beta-lactamase; it binds the enzyme and does not allow it to interact with the antibiotic.

Uses[edit]

Sulbactam is able to inhibit the most common forms of beta-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.

In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

Recently its use in treating Acinetebacter septicemia is receiving renewed interest,

References[edit]

^ Totir MA, Helfand MS, Carey MP, et al. (August 2007). "Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase". Biochemistry 46 (31): 8980–7. doi:10.1021/bi7006146. PMC 2596720. PMID 17630699.

Singh GS (January 2004). "Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam". Mini Rev Med Chem 4 (1): 93–109. doi:10.2174/1389557043487547. PMID 14754446.

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English Journal

In Vitro Synergistic Effects of Antimicrobial Combinations on Extensively Drug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Isolates.

Lee H1, Roh KH2, Hong SG3, Shin HB4, Jeong SH5, Song W6, Uh Y7, Yong D8, Lee K9.
Annals of laboratory medicine.Ann Lab Med.2016 Mar;36(2):138-44. doi: 10.3343/alm.2016.36.2.138.
BACKGROUND: Extensively drug-resistant (XDR) Pseudomonas aeruginosa and Acinetobacter baumannii are a threat to hospitalized patients. We evaluated the effects of antimicrobial combinations on XDR P. aeruginosa and A. baumannii isolates.METHODS: P. aeruginosa and A. baumannii isolates, which were re
PMID 26709261

Spectrum and treatment of anaerobic infections.

Brook I1.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2016 Jan;22(1):1-13. doi: 10.1016/j.jiac.2015.10.010. Epub 2015 Nov 24.
Anaerobes are the most predominant components of the normal human skin and mucous membranes bacterial flora, and are a frequent cause of endogenous bacterial infections. Anaerobic infections can occur in all body locations: the central nervous system, oral cavity, head and neck, chest, abdomen, pelv
PMID 26620376

"Study of Common Bacterial and Fungal Pathogens in Children with Hematological Malignancies during Febrile Neutropenia: Single Center Egyptian Study".

Hagag AA1.
Infectious disorders drug targets.Infect Disord Drug Targets.2015 Dec 30. [Epub ahead of print]
BACKGROUND: Infection 'is a common complication in children with hematological malignancies' during febrile neutropenia.AIM OF THE WORK: The aim of this study was to' evaluate common bacterial and fungal pathogens in children with hematological malignancies during febrile neutropenia in single cente
PMID 26715443

Japanese Journal

クリンダマイシン, 穿刺排膿による扁桃周囲膿瘍治療 : 広域抗菌剤や多剤併用は必要なのか?

竹中幸則,武田和也,喜井正士,橋本典子,猪原秀典
耳鼻咽喉科臨床 104(1), 67-73, 2011-01-01
… Antibiotics used were clindamycin, sulbactam/cefoperazon, cefepime, and carbapenems. …
NAID 10027626338

Antimicrobial Susceptibility of Bordetella bronchiseptica Isolates from Pigs with Respiratory Diseases on Farms in China

ZHAO Zhanqin,XUE Yun,WANG Chen,DING Ke,WU Bin,HE Qigai,CHENG Xiangchao,CHEN Huanchun
Journal of Veterinary Medical Science 73(1), 103-106, 2011
… bronchiseptica isolates were sensitive to polymyxin B and cefoperazone/sulbactam; … 81.0%), ampicillin/sulbactam (127/163; …
NAID 40018701690

Related Pictures

★リンクテーブル★

リンク元	「スルバクタム」「SBT」
拡張検索	「cefoperazon sodium/sulbactam sodium mixture」「ampicillin sodium/sulbactam sodium mixture」「sulbactam sodium」

「スルバクタム」

Sulbactam
Systematic (IUPAC) name
	(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a693021
Pregnancy cat.	?
Legal status	POM (UK)
Routes	Injection
Pharmacokinetic data
Bioavailability	1
Excretion	Kidneys?
Identifiers
CAS number	68373-14-8
ATC code	J01CG01
PubChem	CID 130313
ChemSpider	115306
UNII	S4TF6I2330
KEGG	D08533
ChEBI	CHEBI:9321
ChEMBL	CHEMBL403
Chemical data
Formula	C8H11NO5S
Mol. mass	233.243 g/mol
	SMILES O=S2(=O)C([C@@H](N1C(=O)C[C@H]12)C(=O)O)(C)C;
	InChI InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 ; Key:FKENQMMABCRJMK-RITPCOANSA-N ;
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