WordNet

a muscle relaxant for striated muscle that is used as an adjunct to anesthesia during certain surgical procedures
transient cessation of respiration

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1. 全身麻酔の導入：概要induction of general anesthesia overview [show details]
…to allow spontaneous ventilation immediately after induction and avoid a period of postinduction apnea. If difficulty with SGA placement or initial ventilation is encountered, an additional sedative-hypnotic … facilitate laryngoscopy when endotracheal intubation is planned Unless specifically contraindicated, succinylcholine (SCh) is selected for patients requiring rapid sequence induction and intubation (RSII) and in…
2. 手術室外での小児への迅速導入気管挿管（RSI）：鎮静薬と筋弛緩薬rapid sequence intubation rsi outside of the operating room in children medications for sedation and paralysis [show details]
… the relative efficacy of succinylcholine versus other paralytic agents is presented in the next section. The dose of succinylcholine for infants and children… appropriate doses . Midazolam also causes respiratory depression. As a result, patients may develop apnea before they have received a paralytic agent, decreasing the effectiveness of preoxygenation prior …
3. 全身麻酔の維持：概要maintenance of general anesthesia overview [show details]
…desflurane is particularly advantageous in patients who are older, morbidly obese, or have sleep apnea . Similar to sevoflurane, a disadvantage of desflurane is its high cost during use as the primary … Two classes of NMBAs exist: depolarizing (succinylcholine [SCh]) and nondepolarizing agents (eg,…
4. Perioperative uses of intravenous opioids in adults: General considerationsperioperative uses of intravenous opioids in adults general considerations [show details]
…hypotension, particularly in a hemodynamically unstable patient. Respiratory depression and/or apnea . Opioid-induced respiratory impairment occurs due to depression of the respiratory center in the … followed by remifentanil 3 to 5 mcg/kg, have been described for rapid sequence intubation (eg, when succinylcholine is contraindicated and the prolonged duration of a nondepolarizing neuromuscular blocking agent …
5. 新生児や小児への全身麻酔：麻酔薬および導入法general anesthesia in neonates and children agents and techniques [show details]
… Obstructive sleep apnea – Patients with significant obstructive sleep apnea (especially those less than three years… Neonates sensitivity to succinylcholine is similar to older children and adults. Administration of succinylcholine for routine intubation in children…

English Journal

Human butyrylcholinesterase polymorphism: Molecular modeling.

Lushchekina S1, Delacour H2, Lockridge O3, Masson P3,4.
The International journal of risk & safety in medicine.Int J Risk Saf Med.2015 Nov 27;27 Suppl 1:S80-1. doi: 10.3233/JRS-150699.
BACKGROUND: Prolonged apnoea following injection of ester-containing myoralaxants was first described in 1953. Because a large part of administered succinylcholine is shortly hydrolyzed by plasma butyrylcholinesterase (BChE) under normal conditions, prolonged apnoea was attributed to deficiency in B
PMID 26639724

Premature awakening and underuse of neuromuscular monitoring in a registry of patients with butyrylcholinesterase deficiency.

Thomsen JL1, Nielsen CV2, Palmqvist DF2, Gätke MR2.
British journal of anaesthesia.Br J Anaesth.2015 Jul;115 Suppl 1:i89-i94. doi: 10.1093/bja/aev103.
BACKGROUND: Patients with butyrylcholinesterase (BChE) deficiency can experience prolonged paralysis after receiving suxamethonium or mivacurium. We hypothesized that patients suspected of BChE deficiency had a higher risk of being awakened while paralysed and having respiratory complications if neu
PMID 26174307

Awareness during emergence from anaesthesia: significance of neuromuscular monitoring in patients with butyrylcholinesterase deficiency.

Thomsen JL1, Nielsen CV2, Eskildsen KZ2, Demant MN2, Gätke MR2.
British journal of anaesthesia.Br J Anaesth.2015 Jul;115 Suppl 1:i78-i88. doi: 10.1093/bja/aev096.
BACKGROUND: Butyrylcholinesterase deficiency can result in prolonged paralysis after administration of succinylcholine or mivacurium. We conducted an interview study to assess whether patients with butyrylcholinesterase deficiency were more likely to have experienced awareness during emergence from
PMID 26174305

Japanese Journal

コリンエステラーゼ活性が極低値だった1症例の遺伝子解析

城尾可奈,荒川裕也,野口依子,岡崎葉子,佐藤伊都子,中町祐司,林伸英,河野誠司
医学検査 65(1), 64-69, 2016
コリンエステラーゼ（ChE）はコリンエステルをコリンと有機酸に分解する酵素で，アセチルコリンのみを加水分解するアセチルコリンエステラーゼ（AChE）とブチリルコリン等に作用しコリンと有機酸に分解するブチリルコリンエステラーゼ（BChE）の2種類がある。BChEは肝細胞で産生される蛋白で，肝臓の蛋白合成能の指標として肝機能検査に用いられているが，BChEのみ低値となる先天性BChE欠損症が報告されて …
NAID 130005133683

帝王切開術術前に発見されたコリンエステラーゼ欠損症合併妊娠の1例

佐々木紘子,富井一枝,鷲尾元夫,池辺成三,劉衛東,波田壽一
産婦人科の進歩 56(2), 91-98, 2004
コリンエステラーゼ（ChE）はコリンエステルをコリンと有機酸に分解する酵素で，肝臓をはじめ体内のさまざまな臓器に分布する．臨床では肝臓での蛋白合成能の指標および術前検査として重要である．異常低値患者は日常生活においてとくに支障をきたすことなく生活することができるが，脱分極性筋弛緩薬が投与された際は，術後長期の筋弛緩効果の遷延および遷延性無呼吸が惹起される．またエステル型局所麻酔薬を投与された際は， …
NAID 130001223437

悪性高熱類似の症候を呈した福山型先天性筋ジストロフィー症の１例

中里明彦,七五三秀昭,諸岡啓一,埜中征哉,高木昭夫
脳と発達 16(5), 386-392, 1984
悪性高熱 (MH) は全身麻酔の重篤な副作用であり, 神経筋疾患に認められることが多いため最近関心が持たれてきている.Duchenne型筋ジストロフィー症に合併したという報告が散見されるようになってきているが, 福山型先天性筋ジストロフィー症 (FCMD) とMHについての報告は未だないようである.今回我々は, 3カ月男児の症例を経験した.症例は化膿性髄膜炎で入院中に, 合併した硬膜下水腫の外科治 …
NAID 130004182101