WordNet

characteristic life processes and phenomena of living organisms; "the biology of viruses"
the science that studies living organisms (同)biological_science

PrepTutorEJDIC

Toward Explainable Anticancer Compound Sensitivity Prediction via Multimodal Attention-Based Convolutional Encoders.

Manica M, Oskooei A, Born J, Subramanian V, Sáez-Rodríguez J, Rodríguez Martínez M.
Molecular pharmaceutics. 2019 Oct;().
In line with recent advances in neural drug design and sensitivity prediction, we propose a novel architecture for interpretable prediction of anticancer compound sensitivity using a multimodal attention-based convolutional encoder. Our model is based on the three key pillars of drug sensitivity: co
PMID 31618586

Submolecular dissection reveals strong and specific binding of polyamide-pyridostatin conjugates to human telomere interface.

Mandal S, Kawamoto Y, Yue Z, Hashiya K, Cui Y, Bando T, Pandey S, Hoque ME, Hossain MA, Sugiyama H, Mao H.
Nucleic acids research. 2019 04;47(7)3295-3305.
To modulate biological functions, G-quadruplexes in genome are often non-specifically targeted by small molecules. Here, specificity is increased by targeting both G-quadruplex and its flanking duplex DNA in a naturally occurring dsDNA-ssDNA telomere interface using polyamide (PA) and pyridostatin (
PMID 30820532

Zhou B, Guo Q, Zeng X, Xu M.
Proceedings. IEEE International Conference on Bioinformatics and Biomedicine. 2018 Dec;2018()2467-2473.
Electron Cryo-Tomography (ECT) allows 3D visualization of subcellular structures at the submolecular resolution in close to the native state. However, due to the high degree of structural complexity and imaging limits, the automatic segmentation of cellular components from ECT images is very difficu
PMID 31205800

OKAYAMA Hiroto
Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 88(3), 102-119, 2012
… The 1970s and the following decade are the era of the birth and early development of recombinant DNA technologies, which have entirely revolutionized the modern life science by providing tools that enable us to know the structures of genes and genomes and to dissect their components and understand their functions at the molecular and submolecular levels. …
NAID 130001924735

Ulmer Artur J.,Ritschel Erunst Th.,Zahringer Ulrich [他],HEINE H.,深瀬嘉之,隅田泰生
Trends in glycoscience and glycotechnology 14(76), 53-68, 2002-03-02
内毒素はグラム陰性細菌の外膜の主要な構成成分であり、広範な免疫活性化能を示し、炎症性反応に関与する。この10数年間に内毒素分子に対する化学的、生物学的な新しい知見が付け加えられた。内毒素の部分構成成分についての知識、リピドA類縁体の合成、さらに内毒素アンタゴニストの開発は、内毒素によって引き起こされる細胞活性化過程に関して莫大な情報を与えた。さらに、内毒素と可溶性もしくは細胞性受容体との相互作用、 …
NAID 10012195157