ストレプトリジン
WordNet
- any of several hemolysins derived from strains of streptococcus
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/09 22:54:47」(JST)
[Wiki en表示]
Streptolysin is a streptococcal hemolytic exotoxin.[1][2]
Types include streptolysin O (SLO), which is oxygen-labile, and streptolysin S (SLS), which is oxygen-stable.[3]
An antibody, antistreptolysin O, can be detected in an antistreptolysin O titre.
Streptolysin O is hemolytically active only in a reversibly reduced state, unlike streptolysin S, which is stable in the presence of oxygen. Another difference is that that SLO is antigenic, while SLS is not antigenic due to its small size.
References
- ^ "streptolysin" at Dorland's Medical Dictionary
- ^ Streptolysin at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Sierig G, Cywes C, Wessels MR, Ashbaugh CD (January 2003). "Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci". Infect. Immun. 71 (1): 446–55. doi:10.1128/IAI.71.1.446-455.2003. PMC 143243. PMID 12496195.
- Toxins
- enterotoxin
- neurotoxin
- hemotoxin
- cardiotoxin
- phototoxin
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Bacterial
toxins |
Exotoxin
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Gram
positive
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Bacilli
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Clostridium:
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- tetani
- Tetanospasmin
- Tetanolysin
- perfringens
- difficile
- botulinum
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other:
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- Anthrax toxin
- Listeriolysin O
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Cocci
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- Streptolysin
- Leukocidin
- Panton-Valentine leukocidin
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Staphylococcus
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- Staphylococcus aureus alpha/beta/delta
- Exfoliatin
- Toxic shock syndrome toxin
- Staphylococcal Enterotoxin B (SEB)
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Actinobacteria
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- Cord factor
- Diphtheria toxin
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Gram
negative
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- Shiga toxin
- Verotoxin/shiga-like toxin (E. coli)
- E. coli heat-stable enterotoxin/enterotoxin
- Cholera toxin
- Pertussis toxin
- Pseudomonas exotoxin
- Extracellular adenylate cyclase
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Mechanisms
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Endotoxin
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- Lipopolysaccharide
- Bacillus thuringiensis delta endotoxin
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Virulence
factor
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- Clumping factor A
- Fibronectin binding protein A
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Mycotoxins |
- Aflatoxin
- Amatoxin (alpha-amanitin, beta-amanitin,
- beta-Nitropropionic acid
- gamma-amanitin, epsilon-amanitin)
- Citrinin
- Cytochalasin
- Ergotamine
- Fumonisin (Fumonisin B1, Fumonisin B2)
- Gliotoxin
- Ibotenic acid
- Muscimol
- Ochratoxin
- Patulin
- Phalloidin
- Sterigmatocystin
- Trichothecene
- Vomitoxin
- Zeranol
- Zearalenone
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Invertebrates |
scorpion:
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- Androctonus australis hector insect toxin
- Charybdotoxin
- Maurotoxin
- Agitoxin
- Margatoxin
- Slotoxin
- Scyllatoxin
- Hefutoxin
- Lq2
- Birtoxin
- Bestoxin
- BmKAEP
- Phaiodotoxin
- Imperatoxin
- Pi3
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spider:
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- Latrotoxin
- CSTX
- Cupiennins
- PhTx3
- Stromatoxin
- Vanillotoxin
- Huwentoxin
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mollusca:
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- Conotoxin
- Eledoisin
- Onchidal
- Saxitoxin
- Tetrodotoxin
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Vertebrates |
fish:
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amphibian:
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- (+)-Allopumiliotoxin 267A
- Batrachotoxin
- Bufotoxins
- Arenobufagin
- Bufotalin
- Bufotenin
- Cinobufagin
- Marinobufagin
- Epibatidine
- Histrionicotoxin
- Pumiliotoxin 251D
- Samandarin
- Samandaridine
- Tarichatoxin
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reptile/snake venom:
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- Bungarotoxin
- Alpha-Bungarotoxin
- Beta-Bungarotoxin
- Calciseptine
- Taicatoxin
- Calcicludine
- Cardiotoxin III
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- note: some toxins are produced by lower species and pass through intermediate species
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Description |
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Disease |
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Treatment |
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Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
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Arrestin |
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Membrane-spanning 4A |
- MS4A1
- MS4A2
- MS4A3
- MS4A4A
- MS4A4E
- MS4A5
- MS4A6A
- MS4A6E
- MS4A7
- MS4A8B
- MS4A9
- MS4A10
- MS4A12
- MS4A13
- MS4A14
- MS4A15
- MS4A18
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Myelin |
- Myelin basic protein
- Myelin proteolipid protein
- Myelin oligodendrocyte glycoprotein
- Myelin-associated glycoprotein
- Myelin protein zero
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Pulmonary surfactant |
- Pulmonary surfactant-associated protein B
- Pulmonary surfactant-associated protein C
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Tetraspanin |
- TSPAN1
- TSPAN2
- TSPAN3
- TSPAN4
- TSPAN5
- TSPAN6
- TSPAN7
- TSPAN8
- TSPAN9
- TSPAN10
- TSPAN11
- TSPAN12
- TSPAN13
- TSPAN14
- TSPAN15
- TSPAN16
- TSPAN17
- TSPAN18
- TSPAN19
- TSPAN20
- TSPAN21
- TSPAN22
- TSPAN23
- TSPAN24
- TSPAN25
- TSPAN26
- TSPAN27
- TSPAN28
- TSPAN29
- TSPAN30
- TSPAN31
- TSPAN32
- TSPAN33
- TSPAN34
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Other/ungrouped |
- Calnexin
- LDL-receptor-related protein-associated protein
- Neurofibromin 2
- Presenilin
- HFE
- Phospholipid transfer proteins
- Dysferlin
- STRC
- OTOF
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see also other cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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UpToDate Contents
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English Journal
- Unique Genomic Arrangements in an Invasive Serotype M23 Strain of Streptococcus pyogenes Identify Genes That Induce Hypervirulence.
- Bao Y1, Liang Z2, Booyjzsen C2, Mayfield JA2, Li Y3, Lee SW4, Ploplis VA2, Song H3, Castellino FJ5.
- Journal of bacteriology.J Bacteriol.2014 Dec 1;196(23):4089-102. doi: 10.1128/JB.02131-14. Epub 2014 Sep 15.
- The first genome sequence of a group A Streptococcus pyogenes serotype M23 (emm23) strain (M23ND), isolated from an invasive human infection, has been completed. The genome of this opacity factor-negative (SOF(-)) strain is composed of a circular chromosome of 1,846,477 bp. Gene profiling showed tha
- PMID 25225265
- On the Connection Between Autoimmunity, tic Disorders and Obsessive-Compulsive Disorders: A Meta-Analysis on Anti-Streptolysin O Titres.
- Pozzi M1, Pellegrino P, Carnovale C, Perrone V, Antoniazzi S, Perrotta C, Radice S, Clementi E.
- Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.J Neuroimmune Pharmacol.2014 Dec;9(5):606-14. doi: 10.1007/s11481-014-9561-1. Epub 2014 Aug 5.
- Anti-streptolysin O (ASO) titration is useful in the context of autoimmune pathologies, including specific cases of tic and obsessive-compulsive disorders occurring after streptococcal infections. There is currently a lack of consensus on the use of ASO titres; therefore we performed a meta-analysis
- PMID 25091468
- Dynamin inhibition interferes with inflammasome activation and cytokine gene expression in Streptococcus pyogenes-infected human macrophages.
- Latvala S1, Mäkelä SM, Miettinen M, Charpentier E, Julkunen I.
- Clinical and experimental immunology.Clin Exp Immunol.2014 Nov;178(2):320-33. doi: 10.1111/cei.12425.
- In the present study, we have analysed the ability of Streptococcus pyogenes [Group A streptococcus (GAS)] to activate the NACHT-domain-, leucine-rich repeat- and PYD-containing protein 3 (NALP3) inflammasome complex in human monocyte-derived macrophages and the molecules and signalling pathways inv
- PMID 25079511
Japanese Journal
- Clostridium perfringens TpeL Induces Formation of Stress Fibers via Activation of RhoA-ROCK Signaling Pathway
- , , [他], , , ,
- Biological and Pharmaceutical Bulletin 38(5), 732-739, 2015
- … A recombinant protein (TpeL1–525) derived from the TpeL N-terminal catalytic domain in the presence of streptolysin O (SLO) induced the formation of actin stress fibers in Madin–Darby canine kidney (MDCK) cells in a dose-dependent manner. …
- NAID 130005068100
- A streptolysin S homologue is essential for beta-haemolytic Streptococcus constellatus subsp constellatus cytotoxicity
- Tabata A,Sato Y,Maya K,Nakano K,Kikuchi K,Whiley RA,Ohkura K,Tomoyasu T,Nagamune H
- MICROBIOLOGY-SGM 160, 980-991, 2014
- NAID 120005597641
- Highly Sensitive and Rapid Assay of Substance P and Streptolysin O in Human Serum Using Immuno-liposomes and Gramicidin Channels
- SAKAMOTO Misato,SHOJI Atsushi,SUGAWARA Masao
- Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 29(9), 877-883, 2013-09-10
- NAID 10031196098
Related Links
- 特集:ストレプトリジンO:streptolysin O | ストレプトリジンO(SLO)は分子量約 6 万のβ溶血性連鎖球菌A、CおよびG群によって産生されるスルフヒドリル活性化毒素で、溶連菌感染症で上昇します。この溶血毒素は動物細胞、特に白血球や ...
- streptolysin strep·tol·y·sin (strěp-tŏl'ĭ-sĭn, strěp'tə-lī'sĭn) n. A hemolysin produced by streptococci.
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