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1. A群レンサ球菌：病原性因子および発症機序 group a streptococcus virulence factors and pathogenic mechanisms
2. 連鎖球菌性毒素性ショック症候群の疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of streptococcal toxic shock syndrome
3. 溶連菌感染後糸球体腎炎 poststreptococcal glomerulonephritis
4. 免疫能の正常な患者における発熱および発疹 fever and rash in the immunocompetent patient
5. 連鎖球菌毒素性ショック症候群の治療 treatment of streptococcal toxic shock syndrome

Streptococcal pyrogenic exotoxin G gene in blood and pharyngeal isolates of Streptococcus dysgalactiae subspecies equisimilis has a limited role in pathogenesis.

Korem M, Hidalgo-Grass C, Michael-Gayego A, Nir-Paz R, Salameh S, Moses AE.SourceDepartment of Clinical Microbiology and Infectious Diseases, Jerusalem, Israel. Electronic address: mayak@hadassah.org.il.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.J Microbiol Immunol Infect.2013 Feb 1. pii: S1684-1182(12)00245-9. doi: 10.1016/j.jmii.2012.12.003. [Epub ahead of print]
BACKGROUND: Streptococcus dysgalactiae subspecies equisimilis (SE) causes human infections that clinically resemble infections due to Streptococcus pyogenes (SP). SE expresses several virulence determinants initially identified in SP, including genes encoding streptococcal pyrogenic exotoxins. SE i
PMID 23380619

A Natural Inactivating Mutation in the CovS Component of the CovRS Regulatory Operon in a Pattern D Streptococcal pyogenes Strain Influences Virulence-associated Genes.

Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ.SourceUniversity of Notre Dame, United States.
The Journal of biological chemistry.J Biol Chem.2013 Jan 13. [Epub ahead of print]
SUMMARY A skin-tropic invasive Group A Streptococcus pyogenes (GAS) strain, AP53, contains a natural inactivating mutation in the covS gene (covSM) of the two-component responder (CovR)/sensor (CovS) gene regulatory system. The effects of this mutation on specific GAS virulence determinants have be
PMID 23316057

Determining antibody-binding site of streptococcal pyrogenic exotoxin B to protect mice from group a streptococcus infection.

Tsao N, Cheng MH, Yang HC, Wang YC, Liu YL, Kuo CF.SourceDepartment of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan.
PloS one.PLoS One.2013;8(1):e55028. doi: 10.1371/journal.pone.0055028. Epub 2013 Jan 31.
Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, is an important virulence factor in group A streptococcal (GAS) infection. SPE B binds and cleaves antibody isotypes and further impairs the immune system by inhibiting complement activation. In this study, we examined the antibody-bin
PMID 23383045

中山章文,永江亜紀子,宇井孝爾 [他]
日本臨床微生物学雑誌 = The journal of the Japanese Society for Clinical Microbiology 24(1), 41-46, 2014
NAID 40020069832

谷口隼人,藤崎竜一,石田毅,坂本哲也,森村尚登
日本救急医学会雑誌 25(4), 152-158, 2014
… 黄色ブドウ球菌性AIPFとスーパー抗原の関連性を示唆したKravitzらの報告を参考に患者血清中のブドウ球菌性スーパー抗原（Staphylococcal enterotoxin A, B, C: SEA, SEB, SEC），レンサ球菌性スーパー抗原（Streptococcal pyrogenic exotoxin A: SPEA，toxic shock syndrome toxin-1: TSST-1）を測定したが，いずれも検出することはできなかった。 …
NAID 130004841010

Time course of virulence factors produced by group A streptococcus during a food-borne epidemic

KANNO Takeshi,SAKAGUCHI Kazuko,SUZUKI Jun
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 18(1), 35-40, 2012-02-01
NAID 10030226301