ステリルスルファターゼ
- 関
- steroid sulfatase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/22 17:56:32」(JST)
[Wiki en表示]
Steryl-sulfatase |
Identifiers |
EC number |
3.1.6.2 |
CAS number |
9025-62-1 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
Steryl-sulfatase (EC 3.1.6.2, arylsulfatase, steroid sulfatase, sterol sulfatase, dehydroepiandrosterone sulfate sulfatase, arylsulfatase C, steroid 3-sulfatase, steroid sulfate sulfohydrolase, dehydroepiandrosterone sulfatase, pregnenolone sulfatase, phenolic steroid sulfatase, 3-beta-hydroxysteroid sulfate sulfatase) is an enzyme with system name steryl-sulfate sulfohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction
- 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O 3beta-hydroxyandrost-5-en-17-one + sulfate
Also acts on some related steryl sulfates.
See also
References
- ^ Roy, A.B. (1954). "The steroid sulphatase of Patella vlugata". Biochim. Biophys. Acta 15: 300–301. doi:10.1016/0006-3002(54)90078-5. PMID 13208702.
- ^ Roy, A.B. (1960). "The synthesis and hydrolysis of sulfate esters". Adv. Enzymol. Relat. Subj. Biochem. 22: 205–235. PMID 13744184.
- ^ Stitch, S.R., Halkerston, I.D.K. and Hillman, J. (1965). "The enzymic hydrolysis of steroid conjugates. 1. Sulphatase and β-glucuronidase activity of molluscan extracts". Biochem. J. 63: 705–710. PMID 13355874.
External links
- Steryl-sulfatase at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
- Jiang M1, He J, Kucera H, Gaikwad NW, Zhang B, Xu M, O'Doherty RM, Selcer KW, Xie W.
- The Journal of biological chemistry.J Biol Chem.2014 Mar 21;289(12):8086-97. doi: 10.1074/jbc.M113.535914. Epub 2014 Feb 4.
- The steroid sulfatase (STS)-mediated desulfation is a critical metabolic mechanism that regulates the chemical and functional homeostasis of endogenous and exogenous molecules. In this report, we first showed that the liver expression of Sts was induced in both the high fat diet (HFD) and ob/ob mode
- PMID 24497646
- Hypospadias and variants in genes related to sex hormone biosynthesis and metabolism.
- Carmichael SL1, Witte JS, Ma C, Lammer EJ, Shaw GM.
- Andrology.Andrology.2014 Jan;2(1):130-7. doi: 10.1111/j.2047-2927.2013.00165.x. Epub 2013 Nov 26.
- We examined whether variants in genes related to sex hormone biosynthesis and metabolism were associated with hypospadias in humans. We examined 332 relatively common tag single-nucleotide polymorphisms (tagSNPs) in 20 genes. Analyses included 633 cases (84 mild, 322 moderate, 212 severe and 15 unde
- PMID 24281767
- Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update.
- Gobbi S, Rampa A, Belluti F, Bisi A1.
- Anti-cancer agents in medicinal chemistry.Anticancer Agents Med Chem.2014 Jan;14(1):54-65.
- Estrogens are known to be important in breast cancer growth in both pre- and post-menopausal women. Although circulating estrogen concentrations are very low after menopause, peripheral tissues generate sufficient concentrations to stimulate tumor growth. As aromatase is the rate-limiting enzyme in
- PMID 23869785
Japanese Journal
- MP-498 前立腺癌細胞株におけるsteryl sulfatase activityの抑制に関する研究(一般演題ポスター,第94回日本泌尿器科学会総会)
Related Links
- Steroid sulfatase (or steryl-sulfatase), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded ... " Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase".
Related Pictures
★リンクテーブル★
[★]
- 英
- steryl-sulfatase
- 関
- ステロイドスルファターゼ
[★]
スルファターゼ、サルファターゼ、硫酸エステル加水分解酵素