English Journal
- The Role of Staphylothrombin-Mediated Fibrin Deposition in Catheter-Related Staphylococcus aureus Infections.
- Vanassche T, Peetermans M, Van Aelst LN, Peetermans WE, Verhaegen J, Missiakas DM, Schneewind O, Hoylaerts MF, Verhamme P.SourceCenter for Molecular and Vascular Biology, Department of Cardiovascular Sciences.
- The Journal of infectious diseases.J Infect Dis.2013 Apr 17. [Epub ahead of print]
- Staphylococcus aureus (S. aureus) is a frequent cause of catheter-related infections. S. aureus secretes the coagulases staphylocoagulase and von Willebrand factor-binding protein, both of which form a staphylothrombin complex upon binding to prothrombin. Although fibrinogen and fibrin facilitate th
- PMID 23532100
- Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation.
- Vanassche T, Kauskot A, Verhaegen J, Peetermans WE, van Ryn J, Schneewind O, Hoylaerts MF, Verhamme P.SourceCenter for Molecular and Vascular Biology, University of Leuven, University Hospitals Leuven, B-3000 Leuven, Belgium. thomas.vanassche@med.kuleuven.be
- Thrombosis and haemostasis.Thromb Haemost.2012 Jun;107(6):1107-21. doi: 10.1160/TH11-12-0891. Epub 2012 Mar 22.
- Interactions of Staphylococcus aureus (S. aureus) and platelets play an important role in the pathogenesis of intravascular infections such as infective endocarditis (IE). A typical feature of S. aureus is the ability to generate thrombin activity through the secretion of two prothrombin activating
- PMID 22437005
Japanese Journal
- Enzymatic properties of staphylothrombin, an active molecular complex formed between staphylocoagulase and human prothrombin
- KAWABATA S
- J Biochem (Tokyo) 98, 1603-1614, 1985
- NAID 80002682867
Related Links
- ABSTRACT Staphylocoagulase and von Willebrand binding protein (VWbp) bind to prothrombin to form the staphylothrombin complex that converts fibrinogen into fibrin. To study the role of staphylothrombin and its inhibition by ...
- ... both of which form a staphylothrombin complex upon binding to prothrombin. Although fibrinogen and fibrin facilitate the adhesion of S. aureus to catheters, the contribution of staphylothrombin-mediated fibrin has S. aureus ...
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