spitz nevus

スピッツ母斑

WordNet

1. utter with anger or contempt (同)spit out
2. expel or eject (saliva or phlegm or sputum) from the mouth; "The father of the victim spat at the alleged murderer" (同)ptyalize, ptyalise, spew, spue
3. the act of spitting (forcefully expelling saliva) (同)spitting, expectoration
4. a skewer for holding meat over a fire
5. a narrow strip of land that juts out into the sea (同)tongue
6. any of various stocky heavy-coated breeds of dogs native to northern regions having pointed muzzles and erect ears with a curled furry tail

PrepTutorEJDIC

1. 〈つば・食べ物など〉‘を'『吐く』,吐き出す《+『out』+『名』,+『名』+『out』》 / (…に)〈悪口など〉‘を'吐き出すように言う《+『out』+『名』+『at』+『名』》 / (…に向かって)『つばを吐く』《+『at』(『in』,『into』,『on』,『upon』)+『名』》 / つば(saliva)
2. (焼き肉用の)くし,焼きぐし / (細長く海に突き出た)出州(です),砂州(さす);みさき / 〈肉など〉‘を'焼きぐしに刺す
3. 母斑(ぼはん)(先天性のあざ・ほくろ・そばかすなど)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/01 00:52:33」(JST)

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Spitz nevus
Spitz nevus
Classification and external resources
Specialty	Oncology
ICD-10	D22 (ILDS D22.L32)
ICD-O	M8770/0
DiseasesDB	29807
eMedicine	article/1059623
MeSH	D018332

A Spitz nevus (also known as an epithelioid and spindle-cell nevus, benign juvenile melanoma, and "Spitz's juvenile melanoma") is a benign melanocytic nevus, a type of skin lesion, affecting the epidermis and dermis.

The name juvenile melanoma is generally no longer used as it is misleading: it is not a melanoma, it is a benign lesion; and it can also occur in adults, not only in children.

Pathology

Micrograph of a Spitz nevus showing the characteristic vertically arranged nests of cells ("hanging bananas"). H&E stain.

The cause of Spitz nevi is not yet known. There is an association with sunburn, but causation is not established. Genetic studies of Spitz nevi have shown that most cells have the normal number of chromosomes, however a minority (25%) of cells have been shown to contain extra copies of parts of some chromosomes, such as the short arm of chromosome 11 (11p).

Spitz nevi characteristically have vertically arranged nests of nevus cells that have both a spindled and an epithelioid morphology. Apoptotic cells may be seen at the dermoepidermal junction. The main histologic differential diagnoses are pigmented spindle cell nevus and malignant melanoma.

Epidemiology

Spitz nevi are uncommon. Their annual incidence was estimated in a coastal population of sub-tropical Queensland to be 1.4 cases per 100,000 people. For comparison, the annual incidence of melanoma in the same population, which is high by world standards is 25.4 cases per 100,000 people.

Although they are most commonly found on people in their first two decades of life, the age range for people with Spitz nevi is from 6 months to 71 years, with a mean age of 22 years and a median age of 19 years.

Eponym

The lesion is named after Sophie Spitz, the pathologist who originally described it in 1948.

See also

• List of cutaneous conditions
• List of genes mutated in pigmented cutaneous lesions
• Melanoma with features of a Spitz nevus

UpToDate Contents

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• 1. スピッツ母斑様色素細胞性腫瘍：スピッツ母斑および異型スピッツ腫瘍：臨床的特徴、診断および管理 spitzoid melanocytic neoplasms spitz nevus and atypical spitz tumors
• 2. 後天性色素性母斑（ほくろ） acquired melanocytic nevi moles
• 3. 顔面病変のダーモスコピー dermoscopy of facial lesions
• 4. 小児における黒色腫 melanoma in children
• 5. 化膿性肉芽腫（小葉状毛細血管腫） pyogenic granuloma lobular capillary hemangioma

English Journal

• Acral pigmented Spitz nevus in a child with transepidermal migration of melanocytes: Dermoscopic and reflectance confocal microscopic features.

• Iriarte C1, Rao B2, Haroon A2, Kirkorian AY1,3.
• Pediatric dermatology.Pediatr Dermatol.2018 Jan 4. doi: 10.1111/pde.13385. [Epub ahead of print]
• PMID 29314193

• Myxoid Spitz Nevi: Report of 6 Cases.

• Fernandez-Flores A1,2,3, Riveiro-Falkenbach E4,5, Cassarino DS6.
• The American Journal of dermatopathology.Am J Dermatopathol.2018 Jan;40(1):30-35. doi: 10.1097/DAD.0000000000000890.
• PMID 28394801

• Genomic analysis of a case of agminated Spitz nevi and congenital-pattern nevi arising in extensive nevus spilus.

• Porubsky C1, Teer JK2,3, Zhang Y2, Deschaine M3, Sondak VK4, Messina JL3,4.
• Journal of cutaneous pathology.J Cutan Pathol.2017 Dec 6. doi: 10.1111/cup.13082. [Epub ahead of print]
• PMID 29210482

Japanese Journal

• 悪性黒色腫との鑑別に苦慮した右第5足趾Spitz母斑の1例

• Skin Cancer 31(1), 26-29, 2016
• NAID 130005160214

• 特異な臨床像とダーモスコピー所見を呈した爪囲 Spitz 母斑の 1 例

• 西日本皮膚科 77(5), 483-486, 2015
• NAID 130005137633

• サテライト病変が自然消退したSpitz母斑の1例 (特集 母斑および母斑症)

• 皮膚科の臨床 55(5), 582-584, 2013-05
• NAID 40019690798

Related Links

• Spitz Nevus - Diseases & Conditions - Medscape Reference

Physicians have known for almost a century that some childhood lesions histologically diagnosed as melanomas did not show malignant behavior. The terms juvenile melanoma and prepubertal melanoma were used to describe such lesions. Several attempts were made to establish objective criteria that would ...

• Spitz Nevus - American Osteopathic College of Dermatology ...

Spitz nevus (Epithelioid and Spindle-Cell Nevus) is an uncommon, benign, melanocytic nevus that is usually acquired and has histologic features that overlap with those of melanoma. Spitz nevi were previously diagnosed as ...

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「スピッツ母斑」

「スピッツ母斑」

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英

spitz nevus

関

若年性黒色腫