English Journal

Douroumis D, Hadjileontiadis LJ, Fahr A.SourcePhoqus Pharmaceuticals Limited, 10 Kings Hill Avenue, Kings Hill, West Malling, Kent, ME19 4PQ, UK. dionysios.douroumis@phoqus.com
Pharmaceutical research.Pharm Res.2006 Jun;23(6):1157-64. Epub 2006 May 25.
PURPOSE: The purpose of this study was to evaluate the efficiency of a neuro-fuzzy logic-based methodology to model poorly soluble drug formulations and predict the development of the particle size that has been proven to be an important factor for long-term stability.METHODS: An adaptive neuro-fuzz
PMID 16715373

Mechanism-based active site modification of the soybean sterol methyltransferase by 26,27-dehydrocycloartenol.

Song Z, Zhou W, Liu J, Nes WD.SourceDepartment of Chemistry and Biochemistry, Texas Tech University, PO Box 1061, Lubbock, TX 79409, USA.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2004 Jan 5;14(1):33-6.
26,27-dehydrocycloartenol (26,27-DHC) was shown to be a substrate for the soybean sterol methyltransferase (SMT) as well as a mechanism-based inhibitor of enzyme action. The K(m) and k(cat) for 26,27-DHC was 10 microM and 0.018 min(-1), respectively. SMT catalyzed 26,27-DHC to two products tentative
PMID 14684292

The relationship between the rigidity of the liposomal membrane and the absorption of insulin after nasal administration of liposomes modified with an enhancer containing insulin in rabbits.

Muramatsu K, Maitani Y, Takayama K, Nagai T.SourceDepartment of Pharmaceutics, Hoshi University, Tokyo, Japan.
Drug development and industrial pharmacy.Drug Dev Ind Pharm.1999 Oct;25(10):1099-105.
The relationship between the rigidity of the liposomal membrane and the absorption of insulin after nasal administration of liposomes modified with an enhancer containing insulin was investigated for the nasal delivery of peptide drugs in rabbits. The rigid liposomal membrane makes liposomes stable,
PMID 10529890

Japanese Journal

Effects of Dietary Soysterol Intake on Neutral Sterol Level in Liver, Serum and Feces of Rats.

片桐充昭,清水純夫
栄養学雑誌 51(3), 149-157, 1993
… This study deals with the metabolism of dietary soysterol in the liver, serum and fece of rats. … a standard diet (S), a diet containing 1% cholesterol (C), and a diet containing 3% soysterol (mixture of campesterol and β-sitosterol, 35:57) and 1% cholesterol (P) were given to rats (five males per group) for seven days respectively. …
NAID 130003448242

岡田雪男,多久和正,原文男,白石忠昭,藤田忍,金山保夫,森脇稔幸,安達浩治
日本獣医師会雑誌 41(8), 555-560, 1988
… Soysterol, which contains fatty acids and several kinds of plant sterol. … The treatment with Soysterol was not effective, and all of them were slaughtered.<BR>Hemobiochemical examination showed a decreasing of GOT, γ-GPT and inorganic phosphorus and an increasing of magnesium after 10 months treatment. …
NAID 130003847772

南野久晃,金野慎一郎,本田慶三,元井葭子,牛見忠蔵
日本獣医師会雑誌 37(9), 572-576, 1984
… (proprietary name: Yokuinin) in those of group 2 with 150gof a product (proprietary name: Soysterol) prepared from soybean oil extracts containing fatty acids, several kinds of plant sterols and vitamin E and those of group 3 with 150g of Yokuinin and 150g of Soysterol for 4months. …
NAID 130003847533