WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/05 18:22:12」(JST)
[Wiki en表示]
somatostatin receptor 1 |
Identifiers |
Symbol |
SSTR1 |
Entrez |
6751 |
HUGO |
11330 |
OMIM |
182451 |
RefSeq |
NM_001049 |
UniProt |
P30872 |
Other data |
Locus |
Chr. 14 q13 |
somatostatin receptor 2 |
Identifiers |
Symbol |
SSTR2 |
Entrez |
6752 |
HUGO |
11331 |
OMIM |
182452 |
RefSeq |
NM_001050 |
UniProt |
P30874 |
Other data |
Locus |
Chr. 17 q24 |
somatostatin receptor 3 |
Identifiers |
Symbol |
SSTR3 |
Entrez |
6753 |
HUGO |
11332 |
OMIM |
182453 |
RefSeq |
NM_001051 |
UniProt |
P32745 |
Other data |
Locus |
Chr. 22 q13.1 |
somatostatin receptor 4 |
Identifiers |
Symbol |
SSTR4 |
Entrez |
6754 |
HUGO |
11333 |
OMIM |
182454 |
RefSeq |
NM_001052 |
UniProt |
P31391 |
Other data |
Locus |
Chr. 20 p11.2 |
somatostatin receptor 5 |
Identifiers |
Symbol |
SSTR5 |
Entrez |
6755 |
HUGO |
11334 |
OMIM |
182455 |
RefSeq |
NM_001053 |
UniProt |
P35346 |
Other data |
Locus |
Chr. 16 p13.3 |
There are five known somatostatin receptors:[1]
- SST1 (SSTR1)
- SST2 (SSTR2)
- SST3 (SSTR3)
- SST4 (SSTR4)
- SST5 (SSTR5)
All are G protein-coupled seven transmembrane receptors.
References[edit]
- ^ Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE (1995). "Classification and nomenclature of somatostatin receptors". Trends Pharmacol. Sci. 16 (3): 86–8. doi:10.1016/S0165-6147(00)88988-9. PMID 7792934.
External links[edit]
- Somatostatin Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
Cell surface receptor: G protein-coupled receptors
|
|
Class A:
Rhodopsin like |
|
|
Class B: Secretin like |
Orphan
|
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
|
|
Other
|
- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
|
|
|
Class C: Metabotropic
glutamate / pheromone |
Taste
|
- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
|
|
Other
|
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
|
|
|
Class F:
Frizzled / Smoothened |
Frizzled
|
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
|
|
Smoothened
|
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
Neuropeptide receptors
|
|
G protein-coupled receptor |
Hormone receptors
|
Hypothalamic
|
CRH · FSH · LHRH · TRH · Somatostatin
|
|
Pituitary
|
Vasopressin (1A, 1B, 2) · Oxytocin · LHCG · TSH
|
|
Other
|
Atrial natriuretic factor (NPR3) · Calcitonin · Cholecystokinin (A, B) · VIP
|
|
|
Opioid receptors
|
Delta · Kappa · Mu · Nociceptin
|
|
Other neuropeptide receptors
|
Angiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · Neurotensin
|
|
|
Type I cytokine receptor |
GH · Prolactin
|
|
Enzyme-linked receptor |
Atrial natriuretic factor (NPR1, NPR2)
|
|
Other |
Sigma (1, 2)
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
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English Journal
- Malignant Jugular Paraganglioma: Unusual Presentation on 68Ga DOTANOC PET/CT.
- Jain TK1, Basher RK, Shukla J, Mittal BR, Panda NK.
- Clinical nuclear medicine.Clin Nucl Med.2016 Feb;41(2):150-2. doi: 10.1097/RLU.0000000000001077.
- Metastatic jugular paraganglioma are rare tumors and account for less than 1% of the cases of head and neck tumors. We report a 40-year-old woman of jugular paraganglioma, presenting with right-sided neck swelling, hearing loss, and pulsatile tinnitus. Contrast-enhanced CT temporal bone revealed a m
- PMID 26646996
- Localization of Radiolabeled Somatostatin Analogs in the Spleen.
- Melis M1, Kaemmerer D, de Swart J, Kulkarni HR, Lupp A, Sänger J, Groen HC, Konijnenberg MW, de Jong M, Baum RP.
- Clinical nuclear medicine.Clin Nucl Med.2016 Feb;41(2):e111-4. doi: 10.1097/RLU.0000000000001026.
- Radiolabeled somatostatin (SST) analogs, used to visualize and treat SST receptor (SSTR)-expressing neuroendocrine tumors, also accumulate in the spleen. There is a high interpatient variation and no significant radiation-induced splenic toxicity; however, an absorbed dose-related reduction in splee
- PMID 26462044
- Peptide Receptor Radionuclide Therapy in the Treatment of Neuroendocrine Tumors.
- Kwekkeboom DJ1, Krenning EP2.
- Hematology/oncology clinics of North America.Hematol Oncol Clin North Am.2016 Feb;30(1):179-91. doi: 10.1016/j.hoc.2015.09.009.
- Peptide receptor radionuclide therapy (PRRT) is a promising new treatment modality for inoperable or metastasized gastroenteropancreatic neuroendocrine tumors patients. Most studies report objective response rates in 15% to 35% of patients. Progression-free (PFS) and overall survival (OS) compare fa
- PMID 26614376
Japanese Journal
- Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs.
- Harada Kenichi,Sato Yasunori,Ikeda Hiroko,Maylee Hsu,Igarashi Saya,Okamura Atsushi,Masuda Shinji,Nakanuma Yasuni
- Virchows Archiv : an international journal of pathology 460(3), 281-289, 2012-03
- … In the MANEC cases, in addition to a close histological examination, the proliferative activity and the expression of somatostatin receptor 2A were also evaluated. … Two cases were positive for somatostatin receptor 2A. … Since the neuroendocrine component in biliary MANEC defines the prognosis, it is important to identify it and consider the indications for adjunctive therapy with somatostatin analogues. …
- NAID 120004161542
- Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs
- Harada Kenichi,Sato Yasunori,Ikeda Hiroko,Maylee Hsu,Igarashi Saya,Okamura Atsushi,Masuda Shinji,Nakanuma Yasuni
- Virchows Archiv 460(3), 281-289, 2012-03
- … In the MANEC cases, in addition to a close histological examination, the proliferative activity and the expression of somatostatin receptor 2A were also evaluated. … Two cases were positive for somatostatin receptor 2A. … Since the neuroendocrine component in biliary MANEC defines the prognosis, it is important to identify it and consider the indications for adjunctive therapy with somatostatin analogues. …
- NAID 120003959481
Related Links
- There are five known somatostatin receptors: SST1 (SSTR1); SST2 ... " Classification and nomenclature of somatostatin receptors". Trends ... Somatostatin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Related Pictures
★リンクテーブル★
[★]
- 英
- somatostatin receptor
- 関
- ソマトスタチン受容体
[★]
ソマトスタチン受容体シンチグラフィ, SRS