ソマン中毒
WordNet
- the physiological state produced by a poison or other toxic substance (同)toxic condition, intoxication
- the act of giving poison to a person or animal with the intent to kill
- the basic unit of money in Kyrgyzstan
- the basic unit of money in Uzbekistan
- leafless East Indian vine; its sour milky juice formerly used to make an intoxicating drink (同)haoma, Sarcostemma acidum
- a nerve agent easily absorbed into the body; a lethal cholinesterase inhibitor that is highly toxic when inhaled (同)GD
UpToDate Contents
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English Journal
- Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.
- Price ME1, Docx CJ2, Rice H2, Fairhall SJ2, Poole SJ2, Bird M2, Whiley L2, Flint DP2, Green AC2, Timperley CM2, Tattersall JE2.
- Toxicology letters.Toxicol Lett.2015 Sep 19. pii: S0378-4274(15)30034-5. doi: 10.1016/j.toxlet.2015.08.013. [Epub ahead of print]
- Current organophosphorus nerve agent medical countermeasures do not directly address the nicotinic effects of poisoning. A series of antinicotinic bispyridinium compounds has been synthesized in our laboratory and screened in vitro. Their actions can include open-channel block at the nicotinic recep
- PMID 26325216
- Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
- Myhrer T1, Mariussen E1, Enger S1, Aas P2.
- Neurotoxicology.Neurotoxicology.2015 Sep;50:142-8. doi: 10.1016/j.neuro.2015.08.012. Epub 2015 Aug 28.
- A treatment regimen consisting of HI-6, levetiracetam, and procyclidine (termed the triple regimen) has previously been shown to work as a universal therapy against soman poisoning in rats, since it has capacities to function as both prophylactic and therapeutic measure. The purpose of the present s
- PMID 26318504
- Beneficial effects of a ketamine/atropine combination in soman-poisoned rats under a neutral thermal environment.
- Barbier L1, Canini F2, Giroud C3, Beaup C4, Foquin A5, Maury R6, Denis J7, Peinnequin A8, Dorandeu F9.
- Neurotoxicology.Neurotoxicology.2015 Sep;50:10-9. doi: 10.1016/j.neuro.2015.07.003. Epub 2015 Jul 20.
- Exposure to organophosphorus (OP) compounds, such as pesticides and the chemical warfare agents (soman and sarin), respectively represents a major health problem and a threat for civilian and military communities. OP poisoning may induce seizures, status epilepticus and even brain lesions if untreat
- PMID 26205086
Japanese Journal
- Interethnic Variability of Plasma Paraoxonase (PON1) Activity towards Organophosphates and PON1 Polymorphisms among Asian Populations━A Short Review
- ,
- Industrial Health 46(4), 309-317, 2008
- … Organophosphate (OP) poisoning is a progressively worrying phenomenon as worldwide pesticide production and consumption has doubled. … On average, WHO estimates that 3% of agricultural workers in developing Asian countries suffer an episode of pesticide poisoning every year. … PON1R192 hydrolyses paraoxon faster than PON1Q192 but hydrolyses diazoxon, sarin and soman eight times slower, and vice versa. …
- NAID 130004828512
- Toxicology and pharmacology of bispyridium oximes : Insight into the mechanism of action vs soman poisoning in vivo.
Related Links
- Soman is a human-made chemical warfare agent classified as a nerve agent. Nerve agents are the most toxic and rapidly acting of the known chemical warfare agents. They are similar to pesticides (insect killers) called organophosphates in terms of how they work and the kinds of harmful effects they cause. However, nerve agents are much more potent ...
- Soman (pinacolyl methylphosphonofluoridate or GD [German agent D]) is one of the G class nerve agents (volatile agents associated with inhalation toxicity) that inhibit AChE much more rapidly but less specifically than V class nerve agents (viscous agents associated with transdermal toxicity) ( 2, 6, 8 ).
- DESCRIPTION: Soman (military designation GD) is one of the nerve agents, which are the most toxic of the known chemical warfare agents. It has an odor like camphor or rotting fruit. Exposure to soman can cause death in minutes. A fraction of an ounce (1 to 10 mL) of soman on the skin can be fatal.
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- 英
- soman poisoning, German D poisoning GD poisoning
- 関
- ソマン、神経毒ガス