WordNet
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
- a salt of perchloric acid
PrepTutorEJDIC
- ソジウム,ナトリウム(金属元素;化学記号はNa)
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/16 04:16:09」(JST)
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- 1. ヨード誘発性甲状腺機能異常症 iodine induced thyroid dysfunction
- 2. アミオダロンと甲状腺機能障害 amiodarone and thyroid dysfunction
- 3. 甲状腺ホルモンの合成および生理 thyroid hormone synthesis and physiology
- 4. 先天性代謝異常：個々の障害の発見 inborn errors of metabolism identifying the specific disorder
- 5. 先天性甲状腺機能低下症の臨床的特徴および検出 clinical features and detection of congenital hypothyroidism
English Journal
- Simple electrochemical sensor for caffeine based on carbon and Nafion-modified carbon electrodes.
- Torres AC, Barsan MM, Brett CM.Author information Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal.AbstractA simple, economic, highly sensitive and highly selective method for the detection of caffeine has been developed at bare and Nafion-modified glassy carbon electrodes (GCE). The electrochemical behaviour of caffeine was examined in electrolyte solutions of phosphate buffer saline, sodium perchlorate, and in choline chloride plus oxalic acid, using analytical determinations by fixed potential amperometry, phosphate buffer saline being the best. Modifications of the GCE surface with poly(3,4-ethylenedioxythiophene) (PEDOT), Nafion, and multi-walled carbon nanotubes were tested in order to evaluate possible sensor performance enhancements, Nafion giving the most satisfactory results. The effect of interfering compounds usually found in samples containing caffeine was examined at GCE without and with Nafion coating, to exclude interferences, and the sensors were successfully applied to determine the caffeine content in commercial beverages and drugs.
- Food chemistry.Food Chem.2014 Apr 15;149:215-20. doi: 10.1016/j.foodchem.2013.10.114. Epub 2013 Nov 1.
- A simple, economic, highly sensitive and highly selective method for the detection of caffeine has been developed at bare and Nafion-modified glassy carbon electrodes (GCE). The electrochemical behaviour of caffeine was examined in electrolyte solutions of phosphate buffer saline, sodium perchlorate
- PMID 24295698
- Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening.
- Paul KB, Hedge JM, Rotroff DM, Hornung MW, Crofton KM, Simmons SO.Author information Oak Ridge Institute for Science Education Postdoctoral Fellow, ‡Integrated Systems Toxicology Division, §Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, and ∥National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States.AbstractHigh-throughput screening (HTPS) assays to detect inhibitors of thyroperoxidase (TPO), the enzymatic catalyst for thyroid hormone (TH) synthesis, are not currently available. Herein, we describe the development of a HTPS TPO inhibition assay. Rat thyroid microsomes and a fluorescent peroxidase substrate, Amplex UltraRed (AUR), were employed in an end-point assay for comparison to the existing kinetic guaiacol (GUA) oxidation assay. Following optimization of assay metrics, including Z', dynamic range, and activity, using methimazole (MMI), the assay was tested with a 21-chemical training set. The potency of MMI-induced TPO inhibition was greater with AUR compared to GUA. The dynamic range and Z' score with MMI were as follows: 127-fold and 0.62 for the GUA assay, 18-fold and 0.86 for the 96-well AUR assay, and 11.5-fold and 0.93 for the 384-well AUR assay. The 384-well AUR assay drastically reduced animal use, requiring one-tenth of the rat thyroid microsomal protein needed for the GUA 96-well format assay. Fourteen chemicals inhibited TPO, with a relative potency ranking of MMI > ethylene thiourea > 6-propylthiouracil > 2,2',4,4'-tetrahydroxy-benzophenone > 2-mercaptobenzothiazole > 3-amino-1,2,4-triazole > genistein > 4-propoxyphenol > sulfamethazine > daidzein > 4-nonylphenol > triclosan > iopanoic acid > resorcinol. These data demonstrate the capacity of this assay to detect diverse TPO inhibitors. Seven chemicals acted as negatives: 2-hydroxy-4-methoxybenzophenone, dibutylphthalate, diethylhexylphthalate, diethylphthalate, 3,5-dimethylpyrazole-1-methanol, methyl 2-methyl-benzoate, and sodium perchlorate. This assay could be used to screen large numbers of chemicals as an integral component of a tiered TH-disruptor screening approach.
- Chemical research in toxicology.Chem Res Toxicol.2014 Jan 14. [Epub ahead of print]
- High-throughput screening (HTPS) assays to detect inhibitors of thyroperoxidase (TPO), the enzymatic catalyst for thyroid hormone (TH) synthesis, are not currently available. Herein, we describe the development of a HTPS TPO inhibition assay. Rat thyroid microsomes and a fluorescent peroxidase subst
- PMID 24383450
- Chromatographic resolution of closely related species in pharmaceutical chemistry: dehalogenation impurities and mixtures of halogen isomers.
- Regalado EL, Zhuang P, Chen Y, Makarov AA, Schafer WA, McGachy N, Welch CJ.Author information Merck Research Laboratories , Rahway, New Jersey 07065, United States.AbstractIn recent years, the use of halogen-containing molecules has proliferated in the pharmaceutical industry, where the incorporation of halogens, especially fluorine, has become vitally important for blocking metabolism and enhancing the biological activity of pharmaceuticals. The chromatographic separation of halogen-containing pharmaceuticals from associated isomers or dehalogenation impurities can sometimes be quite difficult. In an attempt to identify the best current tools available for addressing this important problem, a survey of the suitability of four chromatographic method development platforms (ultra high-performance liquid chromatography (UHPLC), core shell HPLC, achiral supercritical fluid chromatography (SFC) and chiral SFC) for separating closely related mixtures of halogen-containing pharmaceuticals and their dehalogenated isosteres is described. Of the 132 column and mobile phase combinations examined for each mixture, a small subset of conditions were found to afford the best overall performance, with a single UHPLC method (2.1 × 50 mm, 1.9 μm Hypersil Gold PFP, acetonitrile/methanol based aqueous eluents containing either phosphoric or perchloric acid with 150 mM sodium perchlorate) affording excellent separation for all samples. Similarly, a survey of several families of closely related halogen-containing small molecules representing the diversity of impurities that can sometimes be found in purchased starting materials for synthesis revealed chiral SFC (Chiralcel OJ-3 and Chiralpak IB, isopropanol or ethanol with 25 mM isobutylamine/carbon dioxide) as well as the UHPLC (2.1 × 50 mm, 1.8 μm ZORBAX RRHD Eclipse Plus C18 and the Gold PFP, acetonitrile/methanol based aqueous eluents containing phosphoric acid) as preferred methods.
- Analytical chemistry.Anal Chem.2014 Jan 7;86(1):805-13. doi: 10.1021/ac403376h. Epub 2013 Dec 20.
- In recent years, the use of halogen-containing molecules has proliferated in the pharmaceutical industry, where the incorporation of halogens, especially fluorine, has become vitally important for blocking metabolism and enhancing the biological activity of pharmaceuticals. The chromatographic separ
- PMID 24359254
Japanese Journal
- ハードカーボン中へのナトリウム挿入に対する非水電解液中のイオン液体種の影響
- , , [他],
- Electrochemistry 80(10), 755-758, 2012
- … The electrochemical insertion and de-insertion of sodium ion in hard carbon has been monitored in electrolytes consisting of sodium perchlorate (NaClO4), propylene carbonate (PC), and an ionic liquid N,N-diethyl-N-methoxyethyl ammonium bis(trifluoromethane sulfonyl)imide (DEMETFSI). … Voltammetric observation revealed that the reversible sodium insertion is inhibited by the content of DEMETFSI in the electrolyte. …
- NAID 130002147492
- 大阪府の水道における過塩素酸イオン濃度とその浄水処理による消長
- 高木 総吉,安達 史恵,宮野 啓一 [他],吉田 直志,小川 有理,李 卉,北川 幹也,関口 陽子,足立 伸一,田辺 信介
- 環境化学 : journal of environmental chemistry 21(3), 251-256, 2011-09-20
- … Perchlorate concentrations in raw and tap water in Osaka, Japan, were determined by IC-MS/MS. The concentrations of perchlorate in raw water and tap water were in the ranges from <0.015 to 0.48 μg/L and from <0.015 to 0.82 μg/L, respectively. … Except for only a few cases, the perchlorate concentration in each tap water sample was at nearly equivalent level to that in the corresponding raw water. …
- NAID 10029688032
- 次亜塩素酸ナトリウム溶液保存中における過塩素酸イオン濃度の増加
- 高野 敬志,伊藤 八十男,千葉 真弘 [他]
- 北海道立衛生研究所報 -(61), 11-13, 2011
- NAID 40019292585
Related Links
- Uses [edit] Sodium perchlorate is the precursor to many other perchlorate salts, often taking advantage of their low solubility relative to NaClO 4 (209 g/100 ml at 25 C). Perchloric acid is made by treating NaClO 4 with HCl. NaClO 4 ...
- Structure, properties, spectra, suppliers and links for: Sodium perchlorate. ... Unstable. Strong oxidizer. Contact with combustible materials can cause fire. Shock sensitive and potentially explosive. Incompatible with a wide range ...
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「perchlorate」
過塩素酸、(化合物)過塩素酸塩