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English Journal

Phenylboronic acid-sugar grafted polymer architecture as a dual stimuli-responsive gene carrier for targeted anti-angiogenic tumor therapy.

Kim J1, Lee YM2, Kim H1, Park D1, Kim J2, Kim WJ3.
Biomaterials.Biomaterials.2016 Jan;75:102-11. doi: 10.1016/j.biomaterials.2015.10.022. Epub 2015 Oct 14.
We present a cationic polymer architecture composed of phenylboronic acid (PBA), sugar-installed polyethylenimine (PEI), and polyethylene glycol (PEG). The chemical bonding of PBA with the diol in the sugar enabled the crosslinking of low-molecular-weight (MW) PEI to form high-MW PEI, resulting in s
PMID 26491998

Ultrasensitive electrochemical biosensor based on reduced graphene oxide-tetraethylene pentamine-BMIMPF6 hybrids for the detection of α2,6-sialylated glycans in human serum.

Li Y1, He J1, Niu Y1, Yu C2.
Biosensors & bioelectronics.Biosens Bioelectron.2015 Dec 15;74:953-9. doi: 10.1016/j.bios.2015.07.073. Epub 2015 Jul 31.
In this paper, a simple, ultrasensitive and label-free electrochemical α2,6-sialylated glycans biosensor based on reduced graphene oxide-tetraethylene pentamine-1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6) hybrids was developed. Due to the abundance of amino groups from reduced graphen
PMID 26257188

Insights into the Impact of Heterogeneous Glycosylation on the Pharmacokinetic Behavior of Follistatin-Fc-Based Biotherapeutics.

Datta-Mannan A1, Huang L1, Pereira J1, Yaden B1, Korytko A1, Croy JE2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Dec;43(12):1882-90. doi: 10.1124/dmd.115.064519. Epub 2015 Sep 9.
Follistatin 315 heparan sulfate-binding deficient mutant human IgG4 Fc fusion (FST-ΔHBS-Fc) is a follistatin (FST) based Fc fusion protein currently being developed as a novel therapy for several potential indications, including muscle wasting. Previous assessments of the pharmacokinetics and thera
PMID 26354950

Urinary Fetuin-A Is a Novel Marker for Diabetic Nephropathy in Type 2 Diabetes Identified by Lectin Microarray

Inoue Kentaro,Wada Jun,Eguchi Jun,Nakatsuka Atsuko,Teshigawara Sanae,Murakami Kazutoshi,Ogawa Daisuke,Terami Takahiro,Katayama Akihiro,Tone Atsuhito,Iseda Izumi,Hida Kazuyuki,Yamada Masao,Ogawa Tomohisa,Makino Hirofumi
PLoS ONE 8(10), 2013-10-15
… We next isolated sialylated glycoproteins by using SSA-lectin affinity chromatography and identified fetuin-A by liquid chromatography-tandem mass spectrometer. …
NAID 120005473079

Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1 alpha-MUC1 pathway

Goudarzi Houman,Iizasa Hisashi,Furuhashi Masako,Nakazawa Seitaro,Nakane Rie,Liang Shanshan,Hida Yasuhiro,Yanagihara Kazuyoshi,Kubo Takanori,Nakagawa Koji,Kobayashi Masanobu,Irimura Tatsuro,Hamada Jun-ichi
Cancer letters 339(1), 82-92, 2013-10-01
… (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; …
NAID 120005345323