シアリダーゼ
- 関
- neuraminidase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/04 23:06:29」(JST)
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Sialidases hydrolyse alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Sialidases may act as pathogenic factors in microbial infections.[1]
Structure of trans-sialidase includes a catalytic beta-propeller domain, a N-terminal lectin-like domain and an irregular beta-stranded domain inserted into the catalytic domain.[2]
See also
Glycoside hydrolase family 33
References
- ^ Rothe B, Rothe B, Roggentin P, Schauer R (1991). "The sialidase gene from Clostridium septicum: cloning, sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins". Mol. Gen. Genet. 226 (1-2): 190–197. doi:10.1007/BF00273603. PMID 2034213.
- ^ Luo M, Luo Y, Li SC, Chou MY, Li YT (1998). "The crystal structure of an intramolecular trans-sialidase with a NeuAc alpha2-->3Gal specificity". Structure 6 (4): 521–530. doi:10.1016/S0969-2126(98)00053-7. PMID 9562562.
This article incorporates text from the public domain Pfam and InterPro IPR004124
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English Journal
- Effect of an Echinacea-Based Hot Drink Versus Oseltamivir in Influenza Treatment: A Randomized, Double-Blind, Double-Dummy, Multicenter, Noninferiority Clinical Trial.
- Rauš K1, Pleschka S2, Klein P3, Schoop R4, Fisher P5.
- Current therapeutic research, clinical and experimental.Curr Ther Res Clin Exp.2015 Apr 20;77:66-72. doi: 10.1016/j.curtheres.2015.04.001. eCollection 2015.
- BACKGROUND: Echinacea has antiviral activity against influenza viruses in vitro and has traditionally been used for treatment of colds and flu.OBJECTIVES: This randomized, double-blind, double-dummy, multicenter, controlled clinical trial compared a new echinacea formulation with the neuraminidase i
- PMID 26265958
- Unique Determinants of Neuraminidase Inhibitor Resistance among N3, N7, and N9 Avian Influenza Viruses.
- Song MS1, Marathe BM2, Kumar G3, Wong SS2, Rubrum A2, Zanin M2, Choi YK4, Webster RG2, Govorkova EA2, Webby RJ5.
- Journal of virology.J Virol.2015 Nov 1;89(21):10891-900. doi: 10.1128/JVI.01514-15. Epub 2015 Aug 19.
- Human infections with avian influenza viruses are a serious public health concern. The neuraminidase (NA) inhibitors (NAIs) are the frontline anti-influenza drugs and are the major option for treatment of newly emerging influenza. Therefore, it is essential to identify the molecular markers of NAI r
- PMID 26292325
- Generation of Live Attenuated Influenza Virus by Using Codon Usage Bias.
- Fan RL1, Valkenburg SA1, Wong CK1, Li OT1, Nicholls JM2, Rabadan R3, Peiris JS1, Poon LL4.
- Journal of virology.J Virol.2015 Nov 1;89(21):10762-73. doi: 10.1128/JVI.01443-15. Epub 2015 Aug 12.
- Seasonal influenza epidemics and occasional pandemics threaten public health worldwide. New alternative strategies for generating recombinant viruses with vaccine potential are needed. Interestingly, influenza viruses circulating in different hosts have been found to have distinct codon usage patter
- PMID 26269186
Japanese Journal
- Syntheses of 2-Deoxy-2,3-didehydro-N-acetylneuraminic Acid Analogues Modified by α-Acylaminoamido Groups at the C-4 Position Using Isocyanide-Based Four-Component Coupling and Biological Evaluation as Inhibitors of Human Parainfluenza Virus Type 1
- Nishino Reiko,Hayakawa Takuya,Takahashi Tadanobu [他]
- Chemical and pharmaceutical bulletin 61(1), 69-74, 2013-01-00
- NAID 40019536408
- Loss-of-Function Mutation in Bi-Functional Marine Bacterial Sialyltransferase
- KAJIWARA Hitomi,KATAYAMA Sakurako,KAKUTA Yoshimitsu [他]
- Bioscience, Biotechnology, and Biochemistry 76(9), 1639-1644, 2012-09-00
- NAID 40019424853
- Minami Akira,Suzuki Takashi
- Trends in glycoscience and glycotechnology 24(135), 112-121, 2012-05-31
- NAID 10030975989
Related Links
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- Search results for sialidase at Sigma-Aldrich ... Compare products: Select the checkbox on up to 4 items, then click 'compare' for a detailed product comparison *Please select more than one item to compare
★リンクテーブル★
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- 英
- sialidase
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- ノイラミニダーゼ neuraminidase、α-N-アセチルノイラミニダーゼ α-N-acetylneuraminidase
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- インフルエンザウイルス
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シアリダーゼ欠損症