serous meningitis

漿液性髄膜炎

WordNet

1. infectious disease characterized by inflammation of the meninges (the tissues that surround the brain or spinal cord) usually caused by a bacterial infection; symptoms include headache and stiff neck and fever and nausea
2. of or producing or containing serum; "a serous exudate"

PrepTutorEJDIC

1. 脳膜炎
2. 漿液(しょうえき)状の,漿液を含む / 水のような,希薄な

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/07 16:39:04」(JST)

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Idiopathic intracranial hypertension
For IIH to be diagnosed, brain scans (such as MRI) must be performed to ensure there is no underlying cause for the increased pressure around the brain
Classification and external resources
Specialty	Neurology
ICD-10	G93.2
ICD-9-CM	348.2
OMIM	243200
DiseasesDB	1331
MedlinePlus	000351
eMedicine	neuro/329 oph/190 neuro/537
Patient UK	Idiopathic intracranial hypertension
MeSH	D011559

Idiopathic intracranial hypertension (IIH), sometimes called by the older names benign intracranial hypertension (BIH) or pseudotumor cerebri (PTC), is a neurological disorder that is characterized by increased intracranial pressure (pressure around the brain) in the absence of a tumor or other diseases. The main symptoms are stroke like-headache, nausea, and vomiting, as well as pulsatile tinnitus (sounds perceived in the ears, with the sound occurring in the same rhythm as the pulse), double vision and other visual symptoms. If untreated, it may lead to swelling of the optic disc in the eye, which can progress to vision loss.

IIH is diagnosed with a brain scan (to rule out other causes) and a lumbar puncture; lumbar puncture may also provide temporary and sometimes permanent relief from the symptoms. Some respond to medication (with the drug acetazolamide), but others require surgery to relieve the pressure. The condition may occur in all age groups, but is most common in women aged 20–40.

Signs and symptoms

The most common symptom of IIH is headache, which occurs in almost all (92–94%) cases. It is characteristically worse in the morning, generalized in character and throbbing in nature. It may be associated with nausea and vomiting. The headache can be made worse by any activity that further increases the intracranial pressure, such as coughing and sneezing. The pain may also be experienced in the neck and shoulders. Many have pulsatile tinnitus, a whooshing sensation in one or both ears (64–87%); this sound is synchronous with the pulse. Various other symptoms, such as numbness of the extremities, generalized weakness, loss of smell, and loss of coordination, are reported more rarely; none are specific for IIH. In children, numerous nonspecific signs and symptoms may be present.

The increased pressure leads to compression and traction of the cranial nerves, a group of nerves that arise from the brain stem and supply the face and neck. Most commonly, the abducens nerve (sixth nerve) is involved. This nerve supplies the muscle that pulls the eye outward. Those with sixth nerve palsy therefore experience horizontal double vision which is worse when looking towards the affected side. More rarely, the oculomotor nerve and trochlear nerve (third and fourth nerve palsy, respectively) are affected; both play a role in eye movements. The facial nerve (seventh cranial nerve) is affected occasionally –- the result is total or partial weakness of the muscles of facial expression on one or both sides of the face.

The increased pressure leads to papilledema, which is swelling of the optic disc, the spot where the optic nerve enters the eyeball. This occurs in practically all cases of IIH, but not everyone experiences symptoms from this. Those who do experience symptoms typically report "transient visual obscurations", episodes of difficulty seeing that occur in both eyes but not necessarily at the same time. Long-term untreated papilledema leads to visual loss, initially in the periphery but progressively towards the center of vision.

Physical examination of the nervous system is typically normal apart from the presence of papilledema, which is seen on examination of the eye with a small device called an ophthalmoscope or in more detail with a fundus camera. If there are cranial nerve abnormalities, these may be noticed on eye examination in the form of a squint (third, fourth, or sixth nerve palsy) or as facial nerve palsy. If the papilledema has been longstanding, visual fields may be constricted and visual acuity may be decreased. Visual field testing by automated (Humphrey) perimetry is recommended as other methods of testing may be less accurate. Longstanding papilledema leads to optic atrophy, in which the disc looks pale and visual loss tends to be advanced.

Causes

"Idiopathic" means "of unknown etiology". Therefore, IIH can only be diagnosed if there is no alternative explanation for the symptoms. Intracranial pressure may be increased due to medications such as high-dose vitamin A derivatives (e.g. isotretinoin for acne), long-term tetracycline antibiotics (for a variety of skin conditions) and hormonal contraceptives. There are numerous other diseases, mostly rare conditions, that may lead to intracranial hypertension. If there is an underlying cause, the condition is termed "secondary intracranial hypertension". Common causes of secondary intracranial hypertension include obstructive sleep apnea (a sleep-related breathing disorder), systemic lupus erythematosus (SLE), chronic kidney disease, and Behçet's disease.

Mechanism

The cause of IIH is not known. The Monro-Kellie rule states that the intracranial pressure is determined by the amount of brain tissue, cerebrospinal fluid (CSF) and blood inside the bony cranial vault. Three theories therefore exist as to why the pressure might be raised in IIH: an excess of CSF production, increased volume of blood or brain tissue, or obstruction of the veins that drain blood from the brain.

The first theory, that of increased production of cerebrospinal fluid, was proposed in early descriptions of the disease. However, there is no experimental data that supports a role for this process in IIH.

The second theory posits that either increased blood flow to the brain or increase in the brain tissue itself may result in the raised pressure. Little evidence has accumulated to support the suggestion that increased blood flow plays a role, but recently Bateman et al. in phase contrast MRA studies have quantified cerebral blood flow (CBF) in vivo and suggests that CBF is abnormally elevated in many patients with IIH. Both biopsy samples and various types of brain scans have shown an increased water content of the brain tissue. It remains unclear why this might be the case.

The third theory suggests that restricted venous drainage from the brain may be impaired resulting in congestion. Many patients with IIH have narrowing of the transverse sinuses. It is not clear whether this narrowing is the pathogenesis of the disease or a secondary phenomenon. It has been proposed that a positive biofeedback loop may exist, where raised ICP (intracranial pressure) causes venous narrowing in the transverse sinuses, resulting in venous hypertension (raised venous pressure), decreased CSF resorption via arachnoid granulation and further rise in ICP.

Diagnosis

The diagnosis may be suspected on the basis of the history and examination. To confirm the diagnosis, as well as excluding alternative causes, several investigations are required; more investigations may be performed if the history is not typical or the patient is more likely to have an alternative problem: children, men, the elderly, or women who are not overweight.

Investigations

Neuroimaging, usually with computed tomography (CT/CAT) or magnetic resonance imaging (MRI), is used to exclude any mass lesions. In IIH these scans typically appear to be normal, although small or slit-like ventricles, dilatation and buckling of the optic nerve sheaths and "empty sella sign" (flattening of the pituitary gland due to increased pressure) and enlargement of Meckel's caves may be seen.

An MR venogram is also performed in most cases to exclude the possibility of venous sinus stenosis/obstruction or cerebral venous sinus thrombosis. A contrast-enhanced MRV (ATECO) scan has a high detection rate for abnormal transverse sinus stenoses. These stenoses can be more adequately identified and assessed with catheter cerebral venography and manometry. Buckling of the bilateral optic nerves with increased perineural fluid is also often noted on MRI imaging.

Lumbar puncture is performed to measure the opening pressure, as well as to obtain cerebrospinal fluid (CSF) to exclude alternative diagnoses. If the opening pressure is increased, CSF may be removed for transient relief (see below). The CSF is examined for abnormal cells, infections, antibody levels, the glucose level, and protein levels. In IIH, by definition all of these are within their normal limits. Occasionally, the CSF pressure measurement may be normal despite very suggestive symptoms. This may be attributable to the fact that CSF pressure may fluctuate over the course of the normal day. If the suspicion of problems remains high, it may be necessary to perform more long-term monitoring of the ICP by a pressure catheter.

Classification

The original criteria for IIH were described by Dandy in 1937.

Dandy criteria

1 Signs & symptoms of increased ICP – CSF pressure >25 cmH2O

2 No localizing signs with the exception of abducens nerve palsy

3 Normal CSF composition

4 Normal to small (slit) ventricles on imaging with no intracranial mass

They were modified by Smith in 1985 to become the "modified Dandy criteria". Smith included the use of more advanced imaging: Dandy had required ventriculography, but Smith replaced this with computed tomography. In a 2001 paper, Digre and Corbett amended Dandy's criteria further. They added the requirement that the patient is awake and alert, as coma precludes adequate neurological assessment, and require exclusion of venous sinus thrombosis as an underlying cause. Furthermore, they add the requirement that no other cause for the raised ICP is found.

Modified Dandy criteria

1 Symptoms of raised intracranial pressure (headache, nausea, vomiting, transient visual obscurations, or papilledema)

2 No localizing signs with the exception of abducens (sixth) nerve palsy

3 The patient is awake and alert

4 Normal CT/MRI findings without evidence of thrombosis

5 LP opening pressure of >25 cmH2O and normal biochemical and cytological composition of CSF

6 No other explanation for the raised intracranial pressure

In a 2002 review, Friedman and Jacobson propose an alternative set of criteria, derived from Smith's. These require the absence of symptoms that could not be explained by a diagnosis of IIH, but do not require the actual presence of any symptoms (such as headache) attributable to IIH. These criteria also require that the lumbar puncture is performed with patient lying sideways, as a lumbar puncture performed in the upright sitting position can lead to artificially high pressure measurements. Friedman and Jacobson also do not insist on MR venography for every patient; rather, this is only required in atypical cases (see "diagnosis" above).

Treatment

The primary goal in treatment of IIH is the prevention of visual loss and blindness, as well as symptom control. IIH is treated mainly through the reduction of CSF pressure and, where applicable, weight loss. IIH may resolve after initial treatment, may go into spontaneous remission (although it can still relapse at a later stage), or may continue chronically.

Lumbar puncture

A lumbar puncture in progress. A large area on the back has been washed with an iodine-based disinfectant leaving brown colouration. In this image the patient is seated upright, which can make the procedure easier to perform but makes any measurement of the opening pressure unreliable.

The first step in symptom control is drainage of cerebrospinal fluid by lumbar puncture. If necessary, this may be performed at the same time as a diagnostic LP (such as done in search of a CSF infection). In some cases, this is sufficient to control the symptoms, and no further treatment is needed.

The procedure can be repeated if necessary, but this is generally taken as a clue that additional treatments may be required to control the symptoms and preserve vision. Repeated lumbar punctures are regarded as unpleasant by patients, and they present a danger of introducing spinal infections if done too often. Repeated lumbar punctures are sometimes needed to control the ICP urgently if the patient's vision deteriorates rapidly.

Medication

The best-studied medical treatment for intracranial hypertension is acetazolamide (Diamox), which acts by inhibiting the enzyme carbonic anhydrase, and it reduces CSF production by six to 57 percent. It can cause the symptoms of hypokalemia (low blood potassium levels), which include muscle weakness and tingling in the fingers. Acetazolamide cannot be used in pregnancy, since it has been shown to cause embryonic abnormalities in animal studies. Also, in human beings it has been shown to cause metabolic acidosis as well as disruptions in the blood electrolyte levels of newborn babies. The diuretic furosemide is sometimes used for a treatment if acetazolamide is not tolerated, but this drug sometimes has little effect on the ICP.

Various analgesics (painkillers) may be used in controlling the headaches of intracranial hypertension. In addition to conventional agents such as paracetamol, a low dose of the antidepressant amitriptyline or the anticonvulsant topiramate have shown some additional benefit for pain relief.

The use of steroids in the attempt to reduce the ICP is controversial. These may be used in severe papilledema, but otherwise their use is discouraged.

Venous sinus stenting

Venous sinus stenoses leading to venous hypertension appear to play a significant part in relation to raised ICP, and stenting of a transverse sinus may resolve venous hypertension, leading to improved CSF resorption, decreased ICP, cure of papilloedema and other symptoms of IIH.

A self-expanding metal stent is permanently deployed within the dominant transverse sinus across the stenosis under general anaesthesia. In general patients are discharged the next day. Patients require double antiplatelet therapy for a period of up to 3 months after the procedure and aspirin therapy for up to 1 year.

In a systematic analysis of 19 studies with 207 cases, there was an 87% improvement in overall symptom rate and 90% cure rate for treatment of papilloedema. Major complications only occurred in 3/207 patients (1.4%). In the largest single series of transverse sinus stenting there was a 11% rate of recurrence after one stent, requiring further stenting.

Due to the permanence of the stent and small but definite risk of complications, most experts will recommend that patients with IIH must have papilloedema and have failed medical therapy or are intolerant to medication before stenting is undertaken.

Consultation with a neurologist, neurophthalmologist and/or ophthalmologist in combination with a neurointerventionalist who performs the procedure is generally recommended.

Surgery

Two main surgical procedures exist in the treatment of IIH: optic nerve sheath decompression and fenestration and shunting. Surgery would normally only be offered if medical therapy is either unsuccessful or not tolerated. The choice between these two procedures depends on the predominant problem in IIH. Neither procedure is perfect: both may cause significant complications, and both may eventually fail in controlling the symptoms. There are no randomized controlled trials to guide the decision as to which procedure is best.

Optic nerve sheath fenestration is an ophthalmological operation that involves the making of an incision in the connective tissue lining of the optic nerve in its portion behind the eye. It is not entirely clear how it protects the eye from the raised pressure, but it may be the result of either diversion of the CSF into the orbit or the creation of an area of scar tissue that lowers the pressure. The effects on the intracranial pressure itself are more modest. Moreover, the procedure may lead to significant complications, including blindness in 1–2%. The procedure is therefore recommended mainly in those who have limited headache symptoms but significant papilledema or threatened vision, or in those who have undergone unsuccessful treatment with a shunt or have a contraindication for shunt surgery.

Shunt surgery, usually performed by neurosurgeons, involves the creation of a conduit by which CSF can be drained into another body cavity. The initial procedure is usually a lumboperitoneal (LP) shunt, which connects the subarachnoid space in the lumbar spine with the peritoneal cavity. Generally, a pressure valve is included in the circuit to avoid excessive drainage when the patient is erect. LP shunting provides long-term relief in about half the cases; others require revision of the shunt, often on more than one occasion—usually due to shunt obstruction. If the lumboperitoneal shunt needs repeated revisions, a ventriculoatrial or ventriculoperitoneal shunt may be considered. These shunts are inserted in one of the lateral ventricles of the brain, usually by stereotactic surgery, and then connected either to the right atrium of the heart or the peritoneal cavity, respectively. Given the reduced need for revisions in ventricular shunts, it is possible that this procedure will become the first-line type of shunt treatment.

It has been shown that in obese people, bariatric surgery (and especially gastric bypass surgery) can lead to resolution of the condition in over 95%.

Prognosis

It is not known what percentage of people with IIH will remit spontaneously, and what percentage will develop chronic disease.

IIH does not normally affect life expectancy. The major complications from IIH arise from untreated or treatment-resistant papilledema. In various case series, the long-term risk of ones vision being significantly affected by IIH is reported to lie anywhere between 10 and 25%.

Epidemiology

The incidence of IIH is strongly determined by sex and body weight. The figures in females are in women between 20 and 45 years old.

On average, IIH occurs in about one per 100,000 people, and can occur in children and adults. The median age at diagnosis is 30. IIH occurs predominantly in women, especially in the ages 20 to 45, who are four to eight times more likely than men to be affected. Overweight and obesity strongly predispose a person to IIH: women who are more than ten percent over their ideal body weight are thirteen times more likely to develop IIH, and this figure goes up to nineteen times in women who are more than twenty percent over their ideal body weight. In men this relationship also exists, but the increase is only five-fold in those over 20 percent above their ideal body weight.

Despite several reports of IIH in families, there is no known genetic cause for IIH. People from all ethnicities may develop IIH. In children, there is no difference in incidence between males and females.

From national hospital admission databases it appears that the need for neurosurgical intervention for IIH has increased markedly over the period between 1988 and 2002. This has been attributed at least in part to the rising prevalence of obesity, although some of this increase may be explained by the increased popularity of shunting over optic nerve sheath fenestration.

History

The first report of IIH was by the German physician Heinrich Quincke, who described it in 1893 under the name serous meningitis. The term "pseudotumor cerebri" was introduced in 1904 by his compatriot Max Nonne. Numerous other cases appeared in the literature subsequently; in many cases, the raised intracranial pressure may actually have resulted from underlying conditions. For instance, the otitic hydrocephalus reported by London neurologist Sir Charles Symonds may have resulted from venous sinus thrombosis caused by middle ear infection. Diagnostic criteria for IIH were developed in 1937 by the Baltimore neurosurgeon Walter Dandy; Dandy also introduced subtemporal decompressive surgery in the treatment of the condition.

The terms "benign" and "pseudotumor" derive from the fact that increased intracranial pressure may be associated with brain tumors. Those patients in whom no tumour was found were therefore diagnosed with "pseudotumor cerebri" (a disease mimicking a brain tumor). The disease was renamed "benign intracranial hypertension" in 1955 to distinguish it from intracranial hypertension due to life-threatening diseases (such as cancer); however, this was also felt to be misleading because any disease that can blind someone should not be thought of as benign, and the name was therefore revised in 1989 to "idiopathic (of no identifiable cause) intracranial hypertension".

Shunt surgery was introduced in 1949; initially, ventriculoperitoneal shunts were used. In 1971, good results were reported with lumboperitoneal shunting. Negative reports on shunting in the 1980s led to a brief period (1988–1993) during which optic nerve fenestration (which had initially been described in an unrelated condition in 1871) was more popular. Since then, shunting is recommended predominantly, with occasional exceptions.

References

External links

• Idiopathic intracranial hypertension at DMOZ

UpToDate Contents

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• 4. グラム陰性桿菌性髄膜炎：疫学、臨床的特徴、および診断 gram negative bacillary meningitis epidemiology clinical features and diagnosis
• 5. 成人における急性細菌性髄膜炎の臨床的特徴および診断 clinical features and diagnosis of acute bacterial meningitis in adults

English Journal

• [The molecular genetic characteristic of RNA of human enterovirus detected in bio-test from child with serous meningitis].

• Onishchenko GG, Petrov AA, Kazantsev AV, Suroviatkin AV, Kokonova MS, Lebedev VN, Alekseev IaI, Varlamov DA, Kutaev DA, Vakhnov EIu, Borisevich SV.
• Klinicheskaia laboratornaia diagnostika.Klin Lab Diagn.2014 Dec;59(12):44-7.
• The article considers molecular genetic characteristic of RNA of human enterovirus detected in bio-test from child with serous meningitis. The nucleotide sequence of genome DNA is analyzed. In 98% it is identical to corresponding nucleotide sequences of strains of human enterovirus A serotype 71 det
• PMID 25872269

• [Clinical characteristics of mumps infection in children and adult patients].

• Begaydarova RKh, Starikov IuG, Devdariani KhG, Dusembaeva AE, Alshinbekova GK.
• Georgian medical news.Georgian Med News.2014 Nov;(236):62-6.
• The aim of the article was to study clinical manifestations of mumps infection (infectious parotitis) - a viral illness that affects glands that produce saliva, pancreas, and nervous system in children and adult patients. 219 patients (42 children and 177 adults) with mumps infection were studied. T
• PMID 25541828

• [Enterovirus non-poliomyelitis infections in Krasnodar region].

• Zhukova LI, Rafeenko GK, Larin FI, Shcherbina LI, Shut' IN, Davydova MA, Vaniukov AA.
• Zhurnal mikrobiologii, epidemiologii, i immunobiologii.Zh Mikrobiol Epidemiol Immunobiol.2014 Jul-Aug;(4):13-7.
• AIM: Evaluation of epidemic situation by non-poliomyelitis enterovirus infections in Krasnodar region in multi-year dynamics and characterization of clinical course of enterovirus serous meningitis in hospitalize patients.MATERIALS AND METHODS: Retrospective analysis of non-poliomyelitis enterovirus
• PMID 25286522

Japanese Journal

• 髄膜炎を反復した両側Mondini型内耳奇形の一症例

• 工藤 典代,笹村 佳美,宇田川 優子,飯田 由美子,杉田 佳信,夜久 有滋
• Otology Japan 7(3), 207-212, 1997-07-28
• … When myringotomy was performed for her left ear for treatment of serous otitis media (SOM), cerebrospinal fluid (CSF) otorrhea was unexpectedly found and Mondini dysplasia was diagnosed by CT. … A total amount of otorrhea was estimated up to 421ml per day at the third day after myringotomy.<BR>Two years after that episode she developed meningitis twice. … Soon after she developed meningitis and CSF otorrhea. …
• NAID 10009318933

• 髄液細胞診により癌性髄膜炎とした卵巣癌の1例

• 宇井 万津男,小澤 聖史,飯塚 真理,菅原 恒一,伊吹 令人,城下 尚,倉林 良幸,木村 茂
• 日本臨床細胞学会雑誌 34(4), 670-674, 1995-07-22
• NAID 110001228438

• 興味あるCT所見を呈した松果体部原発類上皮腫の1例

• 山内 康雄,高原 衍彦,河村 悌夫,松村 浩
• Neurologia medico-chirurgica 25(2), 136-142, 1985-02-15
• … A 69-year-old male was admitted complaining of gait disturbances and diplopia, 2.5 years after an episode of serous meningitis. …
• NAID 110002281516

Related Links

• Serous meningitis | Define Serous meningitis at Dictionary.com

Serous meningitis definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Added to Favorites Dictionary Thesaurus Word Dynamo Quotes Reference Translator Spanish ...

• serous meningitis - definition of serous meningitis by Medical ...

serous meningitis n. Acute meningitis with secondary external hydrocephalus. serous meningitis serous meningitis An obsolete term for arachnoiditis with increased production of serous fluid. se·rous men·in·gi·tis acute meningitis ...

Related Pictures

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★リンクテーブル★

リンク元	「無菌性髄膜炎」
関連記事	「sero」「serous」

「無菌性髄膜炎」

　　[★]

英

aseptic meningitis

ラ

meningitis aseptica

同

漿液性髄膜炎 serous meningitis

関

髄膜炎、ウイルス性髄膜炎、非細菌性髄膜炎

徴候

• 発熱、頭痛、嘔吐、髄膜刺激症状　→　髄膜炎を疑う。

(教科書的には)うっ血乳頭は症状としてはない。

診断

• 脳脊髄液検査の結果で診断する。

「sero」

　　[★]

• comb form.

• 血清

関

blood serum、sera、serum

「serous」

　　[★]

• adj.

• 漿液の

関

serosity