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| Systematic (IUPAC) name | |
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7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid
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| Clinical data | |
| Trade names | SeradAir (India), Seretra (India), Bronica (Japan),[1] Changnuo (China), Mai Xu Jia (China), Quan Kang Nuo (China) |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration |
Oral |
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| Pharmacokinetic data | |
| Protein binding | >96% |
| Biological half-life | 22 hours |
| Identifiers | |
| CAS Number | 112665-43-7 Y |
| ATC code | R03DX06 (WHO) |
| PubChem | CID 2449 |
| ChemSpider | 2355 N |
| UNII | 4U58JM421N Y |
| KEGG | D01123 Y |
| Chemical data | |
| Formula | C22H26O4 |
| Molar mass | 354.43 g/mol |
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| NY (what is this?) (verify) | |
Seratrodast (INN) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma.[2][3] It was the first TP receptor antagonist that was developed as an anti-asthmatic drug and received marketing approval in Japan in 1997.[4] Seratrodast is currently marketed in Japan,[5] China[6] and India[7] (approved in Dec 2012) as an add-on controller therapy in the management of asthma.
Unlike thromboxane synthase inhibitors such as ozagrel, seratrodast does not affect thrombus formation, time to occlusion and bleeding time.[8] Seratrodast has no effect on prothrombin time and activated partial thromboplastin time, thus ruling out any action on blood coagulation cascade.[9]
Contents
- 1 Pharmacodynamics
- 1.1 Airway smooth muscle contraction
- 1.2 Vascular smooth muscle contraction
- 1.3 Plasma extravasation
- 1.4 Neuromodulatory effects
- 1.5 Mucous secretion
- 1.6 Smooth muscle proliferation
- 1.7 Airway hyper-responsiveness
- 2 Pharmacokinetics
- 3 Dosage and administration
- 3.1 Recommended dosage
- 3.2 Pregnancy and lactation
- 3.3 Pediatric use
- 4 Clinical experience
- 4.1 Asthma
- 4.2 Perennial allergic rhinitis
- 4.3 Chronic bronchitis
- 4.4 COPD
- 4.5 Smoker's cough
- 5 Safety and tolerability
- 6 Synthesis
- 7 References
Pharmacodynamics
TXA2 and other bronchoconstrictor prostanoids, like PGD2 and PGF2α, are generated in asthma and participate in acute and chronic inflammatory processes. Seratrodast, being a TP receptor antagonist, inhibits the following pathophysiological processes in asthma:
Airway smooth muscle contraction
Ligand binding studies on TP receptors have shown the existence of TP receptors on airway smooth muscle. Experimental studies have indicated that the contractile potency of TXA2 is about two times more potent than other prostaglandins.[10][11][12] Experiments utilizing several TP receptor antagonists have further supported the view that not only TXA2 but even PGF2α, PGD2 and its metabolite 9α,11β-PGF2 contract airway smooth muscle via direct stimulation of TP receptors, indicating the involvement of TP receptors in airway smooth muscle contractions.[11][12] In studies, Seratrodast competitively inhibited the contractile response to the TXA2 mimetic (analogue), PGD2, 9α,11β-PGF2 and PGF2α.[13] Other than inhibition of actions of prostanoids, Seratrodast, when given orally, inhibited bronchoconstriction in guinea pigs induced by leukotriene D4 (LTD4) and platelet activating factor (PAF).[13]
Vascular smooth muscle contraction
Activation of vascular TP receptors has been observed to invariably induce vasoconstriction.[14] The same has been illustrated by in vitro potency and efficacy of TXA2 in inducing constriction of internal mammary arteries.[15] Seratrodast competitively inhibited the contractile response to TXA2 mimetic (analogue) in guinea pig lung parenchymal strips and dog saphenous vein strips.[13] In anesthetized rabbits, Seratrodast abolished the decrease in internal diameter of small pulmonary arteries in response to TXA2 mimetic (analogue), indicating direct role of activation of TP receptors in vascular smooth muscle contraction.[16]
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Plasma extravasation
TXA2 and PGF2α potently induce plasma exudation in airways.[17] Studies have indicated inhibition of PAF- or leukotriene D4 (LTD4)-induced plasma exudation by TP receptor antagonists, suggesting that TXA2 is endogenously released in response to inflammatory mediators other than prostanoids resulting in airway microvascular leakage.[17]
Neuromodulatory effects
Prostanoids have potent neuromodulatory effects. Experimental studies on isolated arterial preparation have suggested that TXA2 and related prostaglandins may have some vascular effects on adrenergic fibres that have been found to be in close association with bronchial vessels.[18] TXA2 has also been implicated in acting presynaptically to enhance the release or duration of release of acetylcholine, a potent bronchoconstrictor, from cholinergic nerves.[18]
Mucous secretion
Prostanoids such as PGF2α and PGD2 have been observed to significantly increase mucous glycoprotein release,[19][20] while TXA2 has been shown to increase tracheal mucous gel layer.[21] Antagonism of TP receptor was not only observed to inhibit the tracheal mucous gel layer response of TXA2, but was also found to attenuate the mucous gel layer response caused by leukotrienes, indicating an indirect link between leukotrienes and TP receptors.[21]
Smooth muscle proliferation
TXA2 elicits the proliferation of human airway smooth muscle cells as well as vascular smooth muscle cells,[22][23] thus participating in airway smooth muscle hypertrophy and hyperplasia.[24]
Airway hyper-responsiveness
The effects of TXA2 and related prostaglandins on plasma exudation, acetylcholine release and smooth muscle proliferation support the potential role of TP receptor stimulation in the pathogenesis of airway hyper-responsiveness.[25] The airway mucosal edema due to plasma exudation and the smooth muscle proliferation contribute to thickening of the airway wall [25] Plasma exudation leads to liquid filling of the airway interstices formed between luminal epithelial projections, which amplify the luminal narrowing due to airway smooth muscle contraction.[25]
In addition to inhibition of actions of prostanoids, TP receptor antagonism has been shown to prevent increased airway reactivity to allergens,[26] PAF,[27] LTC4, D4,[28][29] and B4,[30] bradykinin,[31] endothelin,[32] endotoxin,[33] and ozone.[34]
Pharmacokinetics
The pharmacokinetics of Seratrodast have been studied in Japanese and Caucasian, including Indian, healthy volunteers.[35][36][37][38] The plasma concentrations of Seratrodast increase with increasing doses. The absorption of Seratrodast is relatively rapid with maximum plasma concentrations of 4.6-6 µg/ml obtained in 3 to 4 hours.[35] Steady state plasma concentrations of seratrodast are reached within 4–5 days.[37] Seratrodast is slowly cleared, mainly by hepatic biotransformation. The drug shows biexponential decay in plasma profiles with a mean elimination half-life of 22 hours.[35][37] Approximately 20% of the administered dose is recovered in the urine, with 60% of the urinary recovery being in the form of conjugates [36]
Dosage and administration
Recommended dosage
The average recommended dose of Seratrodast is 80 mg once daily.[39] Seratrodast has been well tolerated following repeated once daily oral doses of up to a maximum of 320 mg. In elderly patients it is recommended that the treatment should be started with a lower dose of 40 mg/day.[39]
Pregnancy and lactation
There are no adequate and well controlled studies of Seratrodast in pregnant women. The drug should be used in pregnancy only if the potential benefits justify the risk to the fetus.[39] Seratrodast should not be used during lactation.[39]
Pediatric use
The safety and efficacy of Seratrodast has not been established in children (< 18 years of age).[39]
Clinical experience
The efficacy and safety of seratrodast has been established through various clinical studies conducted on over 5000 patients in indications like asthma, perennial allergic rhinitis, chronic bronchitis and chronic pulmonary emphysema.
Asthma
In various clinical studies, seratrodast improved lung function parameters such as FEV1, FVC and PEF, and clinical symptoms of asthma such as wheezing, shortness of breath, cough, expectoration and chest tightness.[40][41][42][43][44] The improvement in PEF with seratrodast (80 mg o.d. for 28 days) was found to be significantly greater than Montelukast (10 mg o.d. for 28 days).[40] With respect to the levels of various biochemical parameters of sputum, seratrodast showed significant reduction in sputum fucose,[40][45] eosinophil cationic protein (ECP) [40][46] and albumin levels.[40][45] The decrease in sputum ECP and albumin levels with seratrodast was found to be better than Montelukast [40] In a 6-week comparative clinical study with zafirlukast 20 mg, seratrodast was observed to have a better control over asthma compared to zafirlukast (71.68% vs. 62.62%).[41] Seratrodast (80 mg o.d.) administered over 12 weeks was found to decrease airway hyper-responsiveness to acetylcholine with significant improvement in PEF, clinical symptoms of asthma and sputum ECP levels.[46] In a 6-week clinical study with seratrodast (40 mg o.d.), significant decrease in the amount and dynamic viscosity of sputum, and reduction in nasal clearance time of saccharin particle were observed.[45] Long term administration of seratrodast (80 mg o.d.) over 2 years was observed to lessen exacerbation rate of asthma in patient after first 12 months of therapy and reduce the average dose of inhaled beclomethasone dipropionate (iBDP).[47]
Perennial allergic rhinitis
Seratrodast has been observed to show improvement in nasal obstruction, nasal discharge and sneezing in patients with allergic rhinitis.[48][49][50][51][52][53][54][55] Improvement rates of nasal obstruction, nasal discharge and sneezing with Seratrodast (80 mg/day) were found to be better than terfenadine (120 mg/day).[48] Concomitant use with Mequitazine was found to have better impact on nasal symptoms than using Mequitazine alone, though there was no significant difference in improvement rate between concomitant group and Seratrodast group.[50] Dose dependent increase in improvement rates of nasal symptoms has been observed with Seratrodast,[51] with equivalent efficacy of 80 mg/day and 120 mg/day dosage of Seratrodast.[52] Seratrodast (80 mg o.d.) administered over 4 weeks was found to significantly improve nasal volume and cross-sectional area.[54] Long term administration of Seratrodast (80 mg o.d.) over 24 weeks was found to be highly effective in treating allergic rhinitis with significant reduction in nasal obstruction, nasal discharge and sneezing.[53]
Chronic bronchitis
In patients with chronic bronchitis, Seratrodast (80 mg o.d. for 4 weeks) was observed to significantly increase the cough threshold compared to placebo, while pranlukast (112.5 mg o.d. for 4 weeks) did not have any impact on the same.[56]
COPD
Seratrodast (80 mg o.d.), administered over 8 weeks in patients with chronic pulmonary emphysema, was shown to significantly improve respiratory distress, evaluated on both the Hugh-Jones classification and the Borg scale, with significant improvement in FVC.[57] Plasma levels of 11-dehydro-TXB2 were also observed to decrease significantly by the end of 8 weeks.[57]
Smoker's cough
There are anecdotal evidences of improvement of cough with once daily dosage of seratrodast. Various experimental studies have been conducted providing fresh evidence for reducing the incidence of smokers cough.[58][59]
Safety and tolerability
In post-marketing study conducted in over 4000 patients by the innovator, the most frequently observed (0.1 to 5%) adverse reactions were elevated levels of liver enzymes such as ALT, AST, ALP, LDH and γ-GTP, nausea, loss of appetite, stomach discomfort, abdominal pain, diarrhea, constipation, dry mouth, taste disturbance, drowsiness, headache, dizziness, palpitations and malaise.[39] Less than 0.1% of patients experienced vomiting, thrombocytopenia, epistaxis, bleeding tendency, insomnia, tremor, numbness, hot flushes and edema.[39] All the adverse reactions reported were of mild to moderate severity, and resolved when the drug was discontinued.[39]
In clinical studies with Seratrodast, no significant difference was observed in the incidence of adverse events when compared with Montelukast.[40] Global assessment towards the therapy with Seratrodast was deemed as “satisfactory-to-excellent” by the investigators.[40] No difference in overall drug compliance was observed with Seratrodast when compared with Montelukast (99.02% vs. 98.06%).[40]
Synthesis
Seratrodast can be prepared in five steps starting from pimelic acid monoester.[60]
References
- ^ Seratrodast, Kyoto Encyclopedia of Genes and Genomes drug database
- ^ Endo S; Akiyama K (November 1996). "[Thromboxane A2 receptor antagonist in asthma therapy]". Nippon Rinsho (in Japanese) 54 (11): 3045–8. PMID 8950952.
- ^ Hada S; Hashizume M; Nishii S; Yoshioka F; Yasunaga K (January 1993). "[Study on the inhibitory effect of AA-2414 on platelet aggregation and its clinical effect in asthmatic patients]". Arerugi (in Japanese) 42 (1): 18–25. PMID 8457165.
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- ^ Changnuo granules, Chia Tai Tianqing Pharm, China
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- ^ Samara EE. "Seratrodast (AA-2414)—A Novel Thromboxane-A2 Receptor Antagonist". Cardiovascular Drug Reviews 14 (3): 272–85. doi:10.1111/j.1527-3466.1996.tb00231.x.
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- ^ a b c An open-labeled, randomized, cross-over bioequivalence study of Seratrodast 80mg under fasting condition. Data on file (appears on website on Seretra)
- ^ a b Hiraga K; Tateno M (1993). "The clinical phase I study of AA-2414, a thromboxane A, receptor antagonist – repeated-dose study at 160 mg once daily for 7 days". Clin Pharmacol 9 (Suppl. 8): 41–55.
- ^ a b c Hussein Z; Samara E; Locke CS; Orchard MA; Ringham GL; Granneman GR (1994). "Characterization of the pharmacokinetics and pharmacodynamics of a new oral thromboxane A2-receptor antagonist AA-2414 in normal subjects: population analysis". Clin Pharmacol Ther 55 (4): 441–50. doi:10.1038/clpt.1994.54. PMID 8162671.
- ^ Samara E; Qian J; Locke CS; Granneman R; Dean R; Killian A (1996). "Single-dose and steady-state pharmacokinetics of seratrodast in healthy male and female volunteers". Pharmac Res 13 (Suppl. 9).
- ^ a b c d e f g h Prescribing information of Bronica, Takeda Pharmaceuticals Co. Ltd., Japan [1]
- ^ a b c d e f g h i A Multi-centric, Double blind, Randomized, Comparative Clinical trial to Evaluate the Efficacy and Safety of Seratrodast 80 mg as compared to Montelukast 10 mg in the treatment of Asthma. Data on file (appears on website on Seretra).
- ^ a b Yin K; Cay Y; Xia X; Chen G; Sun T (2004). "A Double-Blind Randomized Clinical Study in Multiple-Centre Comparing The Effect Of Seratrodast On Asthma With Zafirlukast". J Jiangsu Clin Med (2).
- ^ Li X; Zhao J; Lou Y; Chen H; Zhu D; Tu J (2006). "Seratrodast in treatment of 107 patients with asthma". Chin J New Drugs Clin Rem 25 (10): 729–733.
- ^ Tanaka H; Igarashi T; Saitoh T; Teramoto S; Miyazaki N; Kaneko S; Ohmichi M; Abe S (1999). "Can urinary eicosanoids be a potential predictive marker of clinical response to thromboxane A2 receptor antagonist in asthmatic patients?". Respir Med 93 (12): 891–7. doi:10.1016/s0954-6111(99)90055-0. PMID 10653051.
- ^ Samara E; Cao G; Locke C; Granneman GR; Dean R; Killian A (1997). "Population analysis of the pharmacokinetics and pharmacodynamics of seratrodast in patients with mild to moderate asthma". Clin Pharmacol Ther 62 (4): 426–35. doi:10.1016/S0009-9236(97)90121-1. PMID 9357394.
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- ^ a b Fukuoka T; Miyake S; Umino T; Inase N; Tojo N; Yoshizawa Y (2003). "The effect of Seratrodast on eosinophil cationic protein and symptoms in asthmatics". J Asthma 40 (3): 257–64. doi:10.1081/jas-120018322. PMID 12807169.
- ^ Baba K; Sakakibara A; Yagi T; Niwa S; Wakayama H; Takagi K (2002). "Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: correlation with serum levels of eosinophil cationic protein". Respirology 7 (3): 255–66. doi:10.1046/j.1440-1843.2002.00389.x. PMID 12153692.
- ^ a b Sakakura Y; Unno T; Tasaka T; Baba K; Oyama M; Ogawa N (1991). "Clinical Evaluation of Seratrodast, a Thromboxane A2 Antagonist, in Patients with Perennial Allergic Rhinitis. Multi-center Comparative Double-blind Test with Terfenadine". J Clin Ther Med 15 (2): 267–307.
- ^ Ishikawa T; Unno T; Baba K; Sakakura Y; Oyama M (1991). "A Study on Efficacy and Safety of 20 mg/day, 40 mg/day, 80 mg/day of Seratrodast, a Thromboxane A2 Receptor Antagonist on Perennial Allergic Rhinitis Patients. An Early Phase II Study". J Clin Ther Med 15 (2): 147–82.
- ^ a b Unno T; Kawabori S; Kaga K; Ichimura K; Sakakura Y; Ukai K; Mogi G (1991). "Effect of Combination Therapy with Seratrodast and Mequitazine on Perennial Allergic Rhinitis". J Clin Ther Med 15 (2): 309–37.
- ^ a b Sakakura Y; Unno T; Takasaka T; Baba K; Oyama M; Ogawa N (1991). "Dose Finding Study of Seratrodast, a Thromboxane A2 Antagonist, in Patients with Perennial Allergic Rhinitis. A Multi-center, Double-blind Comparative Study". J Clin Ther Med 15 (2): 213–45.
- ^ a b Unno T; Kawabori S; Kaga K; Ichimura K (1991). "Study on Administration of 80 mg/day and 120 mg/day of Seratrodast in Perennial Allergic Rhinitis Patients". J Clin Ther Med 15 (2): 247–66.
- ^ a b Yajin K; Hirakawa K; Takebayashi S; Omura R; Yamashita T; Watanabe H; Tada W; Nikaido M; Nagasawa A (1991). "Clinical Evaluation on 12-week Administration of Seratrodast, a Thromboxane A2 Antagonist, in Perennial Allergic Rhinitis". J Clin Ther Med 15 (2): 373–88.
- ^ a b Sakakura Y; Unno T; Ichimura K; Kase Y; Ukai K; Yamagiwa M; Nonaka S; Fujita T; Fujita K (1991). "J Clin Ther Med" 15 (2): 183–211.
- ^ Masuda Y; Ogawara T; Akagi S; Saito C; Takehisa T; Sasaki O; Iguchi I; Aochi K; Nagano T (1991). "Efficacy and Safety on 12-week Administration of Seratrodast, a Thromboxane A2 Antagonist, in Patients with Perennial Allergic Rhinitis". J Clin Ther Med 15 (2): 355–71.
- ^ Ishiura Y; Fujimura M; Yamamori C; Nobata K; Myou S; Kurashima K; Takegoshi T (2003). "Thromboxane antagonism and cough in chronic bronchitis". Annals of Medicine 35 (2): 135–9. doi:10.1080/07853890310010032. PMID 12795341.
- ^ a b Horiguchi T; Tachikawa S; Kondo R; Shiga M; Hirose M; Fukumoto K (2002). "Study on the usefulness of Seratrodast in the treatment of chronic pulmonary emphysema". Arzneimittelforschung 52 (10): 764–8. doi:10.1055/s-0031-1299963. PMID 12442639.
- ^ An J; Li JQ; Wang T; Li XO; Guo LL; Wan C; Liao ZL; Dong JJ; Xu D; Wen FQ. (2013). "Blocking of thromboxane A(2) receptor attenuates airway mucus hyperproduction induced by cigarette smoke". Eur J Pharmacol 703 (1–3): 11–7. doi:10.1016/j.ejphar.2013.01.042. PMID 23399768.
- ^ Wordpress Seretra Blog
- ^ Shiraishi M; Kato K; Terao S; Ashida Y; Terashita Z; Kito G (September 1989). "Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation". Journal of Medicinal Chemistry 32 (9): 2214–21. doi:10.1021/jm00129a030. PMID 2769691.
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English Journal
- Possible role of thromboxane A2 in remote hind limb preconditioning-induced cardioprotection.
- Sharma R1, Randhawa PK1, Singh N1, Jaggi AS2.
- Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2015 Nov 3. [Epub ahead of print]
- Remote hind limb preconditioning (RIPC) is a protective strategy in which short episodes of ischemia and reperfusion in a remote organ (hind limb) protects the target organ (heart) against sustained ischemic reperfusion injury. The present study was designed to investigate the possible role of throm
- PMID 26531833
- Crystal structure of 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-cyclo-hexa-1,4-dien-1-yl)hepta-noate 1,3-dihy-droxy-2-(hy-droxy-meth-yl)propan-2-aminium monohydrate: a new solid form of seratrodast.
- Lou B1.
- Acta crystallographica. Section E, Structure reports online.Acta Crystallogr Sect E Struct Rep Online.2014 Sep 20;70(Pt 10):228-30. doi: 10.1107/S1600536814020625. eCollection 2014.
- In the title hydrated salt, C4H12NO3 (+)·C22H25O4 (-)·H2O, seratrodast [systematic name: 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-cyclo-hexa-1,4-dien-1-yl)hepta-noic acid] crystallized with trometamol [systematic name: 2-amino-2-(hydroxyméth-yl)propane-1,3-diol] to form a monohydrated salt form of s
- PMID 25484659
- The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle.
- Hennenberg M1, Miljak M, Herrmann D, Strittmatter F, Walther S, Rutz B, Hocaoglu Y, Kunit T, Schreiber A, Andersson KE, Stief CG, Gratzke C.
- American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Nov 15;305(10):F1383-90. doi: 10.1152/ajprenal.00380.2013. Epub 2013 Sep 18.
- Inhibition of prostate smooth muscle contraction is an important strategy for medical treatment of lower urinary tract symptoms (LUTS). Besides α1-adrenoceptors, prostate smooth muscle contraction is induced by activation of thromboxane (TXA2) receptors (TXA2-R). Here, we examined the effects of th
- PMID 24049147
Japanese Journal
- Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice
- Suzuki Yuh,Inoue Toshio,Yamamoto Atsuki [他],Sugimoto Yukio
- Biological and Pharmaceutical Bulletin 34(4), 507-510, 2011
- … In the present study, we investigated the prophylactic effects of the histamine H1 receptor antagonist epinastine and the TXA2 receptor antagonist ramatroban and seratrodast on mouse models of allergic rhinitis. … Seratrodast showed no effect on nasal symptoms and eosinophil infiltration into the nasal mucosa. …
- NAID 130000657839
- Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
- Jin Xin,Satoh-Otonashi Yukiko,Zamami Yoshito [他],HOBARA Narumi,KOYAMA Toshihiro,SUN Pengyuan,LI Simin,KITAMURA Yoshihisa,KAWASAKI Hiromu
- Journal of pharmacological sciences 111(4), 372-380, 2009-12-20
- … Indomethacin, seratrodast, or tempol but not catalase significantly reduced methoxamine-induced vasoconstriction in adult preparations with endothelium. …
- NAID 10026154607
- Two Pharmacological Phases in Antigen-Induced Immediate Airway Response in Rats(Pharmacology)
- Miyagawa Naoki,Iwasaki Hidenori,Kato Toshinobu [他],TANAKA Masaru,SHIBATA Tsutomu,WAKITANI Korekiyo
- Biological & pharmaceutical bulletin 31(12), 2260-2264, 2008-12-01
- … In this study, we established an ovalbumin (OVA)-induced IAR model using noninvasive measurement in rats, and evaluated the effects of commonly used and effective antiasthmatic drugs, i.e. ketotifen (antihistamine), pranlukast (anti-leukotriene C_4/D_4/E_4 (LT)), seratrodast (anti-thromboxane A_2 (TXA_2)), salbutamol (β2-agonist), and prednisolone (steroid). … the reaction from 3 to 6min after challenge), while pranlukast and seratrodast suppressed only the early phase (EP; …
- NAID 110007005026
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- Seratrodast is used in the treatment of asthma.get complete information about seratrodast including usage, side effects, drug interaction, expert advice along with medicines associated with seratrodast at 1mg.com
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