seratrodast

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/17 15:54:42」(JST)

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English Journal

  • Possible role of thromboxane A2 in remote hind limb preconditioning-induced cardioprotection.
  • Sharma R1, Randhawa PK1, Singh N1, Jaggi AS2.
  • Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2015 Nov 3. [Epub ahead of print]
  • Remote hind limb preconditioning (RIPC) is a protective strategy in which short episodes of ischemia and reperfusion in a remote organ (hind limb) protects the target organ (heart) against sustained ischemic reperfusion injury. The present study was designed to investigate the possible role of throm
  • PMID 26531833
  • Crystal structure of 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-cyclo-hexa-1,4-dien-1-yl)hepta-noate 1,3-dihy-droxy-2-(hy-droxy-meth-yl)propan-2-aminium monohydrate: a new solid form of seratrodast.
  • Lou B1.
  • Acta crystallographica. Section E, Structure reports online.Acta Crystallogr Sect E Struct Rep Online.2014 Sep 20;70(Pt 10):228-30. doi: 10.1107/S1600536814020625. eCollection 2014.
  • In the title hydrated salt, C4H12NO3 (+)·C22H25O4 (-)·H2O, seratrodast [systematic name: 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-cyclo-hexa-1,4-dien-1-yl)hepta-noic acid] crystallized with trometamol [systematic name: 2-amino-2-(hydroxyméth-yl)propane-1,3-diol] to form a monohydrated salt form of s
  • PMID 25484659
  • The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle.
  • Hennenberg M1, Miljak M, Herrmann D, Strittmatter F, Walther S, Rutz B, Hocaoglu Y, Kunit T, Schreiber A, Andersson KE, Stief CG, Gratzke C.
  • American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Nov 15;305(10):F1383-90. doi: 10.1152/ajprenal.00380.2013. Epub 2013 Sep 18.
  • Inhibition of prostate smooth muscle contraction is an important strategy for medical treatment of lower urinary tract symptoms (LUTS). Besides α1-adrenoceptors, prostate smooth muscle contraction is induced by activation of thromboxane (TXA2) receptors (TXA2-R). Here, we examined the effects of th
  • PMID 24049147

Japanese Journal

  • Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice
  • Suzuki Yuh,Inoue Toshio,Yamamoto Atsuki [他],Sugimoto Yukio
  • Biological and Pharmaceutical Bulletin 34(4), 507-510, 2011
  • … In the present study, we investigated the prophylactic effects of the histamine H1 receptor antagonist epinastine and the TXA2 receptor antagonist ramatroban and seratrodast on mouse models of allergic rhinitis. … Seratrodast showed no effect on nasal symptoms and eosinophil infiltration into the nasal mucosa. …
  • NAID 130000657839
  • Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
  • Jin Xin,Satoh-Otonashi Yukiko,Zamami Yoshito [他],HOBARA Narumi,KOYAMA Toshihiro,SUN Pengyuan,LI Simin,KITAMURA Yoshihisa,KAWASAKI Hiromu
  • Journal of pharmacological sciences 111(4), 372-380, 2009-12-20
  • … Indomethacin, seratrodast, or tempol but not catalase significantly reduced methoxamine-induced vasoconstriction in adult preparations with endothelium. …
  • NAID 10026154607
  • Two Pharmacological Phases in Antigen-Induced Immediate Airway Response in Rats(Pharmacology)
  • Miyagawa Naoki,Iwasaki Hidenori,Kato Toshinobu [他],TANAKA Masaru,SHIBATA Tsutomu,WAKITANI Korekiyo
  • Biological & pharmaceutical bulletin 31(12), 2260-2264, 2008-12-01
  • … In this study, we established an ovalbumin (OVA)-induced IAR model using noninvasive measurement in rats, and evaluated the effects of commonly used and effective antiasthmatic drugs, i.e. ketotifen (antihistamine), pranlukast (anti-leukotriene C_4/D_4/E_4 (LT)), seratrodast (anti-thromboxane A_2 (TXA_2)), salbutamol (β2-agonist), and prednisolone (steroid). … the reaction from 3 to 6min after challenge), while pranlukast and seratrodast suppressed only the early phase (EP; …
  • NAID 110007005026

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Related Pictures

Mechanism Of Action Seratrodast Fig: 3D Pharmacophore model of SeratrodastMechanism Of Action Seratrodast Fig: 3D Pharmacophore model of SeratrodastSeratrodast can be prepared in five steps  Seratrodast (ABT-001) | Drug Metabolism



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