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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/17 15:54:42」(JST)

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English Journal

  • Possible role of thromboxane A2 in remote hind limb preconditioning-induced cardioprotection.
  • Sharma R1, Randhawa PK1, Singh N1, Jaggi AS2.
  • Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2015 Nov 3. [Epub ahead of print]
  • Remote hind limb preconditioning (RIPC) is a protective strategy in which short episodes of ischemia and reperfusion in a remote organ (hind limb) protects the target organ (heart) against sustained ischemic reperfusion injury. The present study was designed to investigate the possible role of throm
  • PMID 26531833
  • Crystal structure of 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-cyclo-hexa-1,4-dien-1-yl)hepta-noate 1,3-dihy-droxy-2-(hy-droxy-meth-yl)propan-2-aminium monohydrate: a new solid form of seratrodast.
  • Lou B1.
  • Acta crystallographica. Section E, Structure reports online.Acta Crystallogr Sect E Struct Rep Online.2014 Sep 20;70(Pt 10):228-30. doi: 10.1107/S1600536814020625. eCollection 2014.
  • In the title hydrated salt, C4H12NO3 (+)·C22H25O4 (-)·H2O, seratrodast [systematic name: 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-cyclo-hexa-1,4-dien-1-yl)hepta-noic acid] crystallized with trometamol [systematic name: 2-amino-2-(hydroxyméth-yl)propane-1,3-diol] to form a monohydrated salt form of s
  • PMID 25484659
  • The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle.
  • Hennenberg M1, Miljak M, Herrmann D, Strittmatter F, Walther S, Rutz B, Hocaoglu Y, Kunit T, Schreiber A, Andersson KE, Stief CG, Gratzke C.
  • American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Nov 15;305(10):F1383-90. doi: 10.1152/ajprenal.00380.2013. Epub 2013 Sep 18.
  • Inhibition of prostate smooth muscle contraction is an important strategy for medical treatment of lower urinary tract symptoms (LUTS). Besides α1-adrenoceptors, prostate smooth muscle contraction is induced by activation of thromboxane (TXA2) receptors (TXA2-R). Here, we examined the effects of th
  • PMID 24049147

Japanese Journal

  • Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice
  • Suzuki Yuh,Inoue Toshio,Yamamoto Atsuki [他],Sugimoto Yukio
  • Biological and Pharmaceutical Bulletin 34(4), 507-510, 2011
  • … In the present study, we investigated the prophylactic effects of the histamine H1 receptor antagonist epinastine and the TXA2 receptor antagonist ramatroban and seratrodast on mouse models of allergic rhinitis. … Seratrodast showed no effect on nasal symptoms and eosinophil infiltration into the nasal mucosa. …
  • NAID 130000657839
  • Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
  • Jin Xin,Satoh-Otonashi Yukiko,Zamami Yoshito [他],HOBARA Narumi,KOYAMA Toshihiro,SUN Pengyuan,LI Simin,KITAMURA Yoshihisa,KAWASAKI Hiromu
  • Journal of pharmacological sciences 111(4), 372-380, 2009-12-20
  • … Indomethacin, seratrodast, or tempol but not catalase significantly reduced methoxamine-induced vasoconstriction in adult preparations with endothelium. …
  • NAID 10026154607
  • Two Pharmacological Phases in Antigen-Induced Immediate Airway Response in Rats(Pharmacology)
  • Miyagawa Naoki,Iwasaki Hidenori,Kato Toshinobu [他],TANAKA Masaru,SHIBATA Tsutomu,WAKITANI Korekiyo
  • Biological & pharmaceutical bulletin 31(12), 2260-2264, 2008-12-01
  • … In this study, we established an ovalbumin (OVA)-induced IAR model using noninvasive measurement in rats, and evaluated the effects of commonly used and effective antiasthmatic drugs, i.e. ketotifen (antihistamine), pranlukast (anti-leukotriene C_4/D_4/E_4 (LT)), seratrodast (anti-thromboxane A_2 (TXA_2)), salbutamol (β2-agonist), and prednisolone (steroid). … the reaction from 3 to 6min after challenge), while pranlukast and seratrodast suppressed only the early phase (EP; …
  • NAID 110007005026

Related Links

[Seratrodast] [112665-43-7] | 価格や在庫、物性値などの詳細情報ページです。 Japan ホーム サイトマップ MyTCI Change Country 日本語 English 製品情報 受託合成・大量製造サービス カタログダウンロード・出展情報 企業情報 menu ...
Seratrodast is used in the treatment of asthma.get complete information about seratrodast including usage, side effects, drug interaction, expert advice along with medicines associated with seratrodast at

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Mechanism Of Action Seratrodast Fig: 3D Pharmacophore model of SeratrodastMechanism Of Action Seratrodast Fig: 3D Pharmacophore model of SeratrodastSeratrodast can be prepared in five steps  Seratrodast (ABT-001) | Drug Metabolism