- (コレステロールや金属イオン等を補足する機能を有する物質)捕捉剤
- (金属の場合)金属イオン封鎖剤
- 関
- scavenger
WordNet
- a chemical agent that is added to a chemical mixture to counteract the effects of impurities
- any animal that feeds on refuse and other decaying organic matter
PrepTutorEJDIC
- 腐肉を常食とする動物(ハゲタカ(vulture)・ハイエナ(hyena)など) / (食物や金目のものを探して)ごみあさりをする人
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/12 18:11:54」(JST)
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A sequestrant is a term for a food additive. Sequestrants improve the quality and stability of the food products. Sequestrants form chelate complexes with polyvalent metal ions, especially copper, iron and nickel, which serve as catalysts in the oxidation of the fats in the food. Sequestrants are a type of preservative.
The name comes from Latin and means "to withdraw from use"[citation needed].
Common sequestrants are:
- Calcium chloride (E509)
- Calcium disodium ethylene diamine tetra-acetate (E385)
- Glucono delta-lactone (E575)
- Sodium gluconate (E576)
- Potassium gluconate (E577)
- Sodium tripolyphosphate
- Sodium hexametaphosphate (E452i)
Sodium and calcium salts of EDTA are also commonly used in many foods and beverages.
UpToDate Contents
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English Journal
- Colesevelam for Type 2 diabetes mellitus: an abridged Cochrane review*.
- Ooi CP, Loke SC.Author information Endocrine Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Serdang, Malaysia; Institute of Gerontology, Universiti Putra Malaysia, Serdang, Malaysia.AbstractAIM: Colesevelam, a second-generation bile acid sequestrant, may be beneficial in controlling both glycaemia and lipids simultaneously. Our goal was to evaluate the systemic effects of colesevelam on Type 2 diabetes mellitus.
- Diabetic medicine : a journal of the British Diabetic Association.Diabet Med.2014 Jan;31(1):2-14. doi: 10.1111/dme.12295. Epub 2013 Sep 11.
- AIM: Colesevelam, a second-generation bile acid sequestrant, may be beneficial in controlling both glycaemia and lipids simultaneously. Our goal was to evaluate the systemic effects of colesevelam on Type 2 diabetes mellitus.METHOD: The original Cochrane review was conducted using the methodology f
- PMID 24024701
- Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention.
- Pattni SS, Brydon WG, Dew T, Johnston IM, Nolan JD, Srinivas M, Basumani P, Bardhan KD, Walters JR.Author information Department of Medicine, Section of Hepatology & Gastroenterology, Imperial College London & Imperial College Healthcare, London, UK.AbstractBACKGROUND: Bile acid diarrhoea is a common, under-diagnosed cause of chronic watery diarrhoea, responding to specific treatment with bile acid sequestrants. We previously showed patients with bile acid diarrhoea have lower median levels compared with healthy controls, of the ileal hormone fibroblast growth factor 19 (FGF19), which regulates bile acid synthesis.
- Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2013 Oct;38(8):967-76. doi: 10.1111/apt.12466. Epub 2013 Aug 27.
- BACKGROUND: Bile acid diarrhoea is a common, under-diagnosed cause of chronic watery diarrhoea, responding to specific treatment with bile acid sequestrants. We previously showed patients with bile acid diarrhoea have lower median levels compared with healthy controls, of the ileal hormone fibroblas
- PMID 23981126
- Role of colesevelam in combination lipid-lowering therapy.
- Jones MR, Nwose OM.Author information , Port St. Lucie, FL, USA.AbstractHyperlipidemia is associated with an increased risk of cardiovascular events; reducing low-density lipoprotein cholesterol (LDL-C), the primary target for cholesterol-lowering therapy, lowers the risk for such events. Although bile acid sequestrants were the first class of drugs to show a mortality benefit related to LDL-C lowering, statins are now considered first-line pharmacological therapy for reducing LDL-C levels because of their potency and their remarkable record of successful outcomes studies. Nevertheless, a substantial proportion of patients do not achieve LDL-C goals with statin monotherapy. In addition, because of adverse effects (primarily myopathy), some patients may be unwilling to use or unable to tolerate statin therapy at all or may not tolerate a full therapeutic statin dose. Also, statins may increase risk of new-onset diabetes in patients at high risk for diabetes. Thus, there remains a need for other lipid-lowering drugs to be used in combination with or in place of statins. The purpose of this article is to review available data from the literature on the use of colesevelam, a second-generation bile acid sequestrant, in combination with other lipid-lowering agents. Colesevelam has been studied in combination with statins, niacin, fibrates, and ezetimibe (including some three-drug combinations). An additive reduction in LDL-C was seen with all combinations. Other observed effects of colesevelam in combination with other lipid-lowering drugs include reductions in apolipoprotein (apo) B (with statins, fibrates, ezetimibe, statin plus niacin, or statin plus ezetimibe) and high-sensitivity C-reactive protein (with statins), and increases in apo A-I (with statins, ezetimibe, or statins plus niacin). Triglyceride levels remained relatively unchanged when colesevelam was combined with statins, fibrates, ezetimibe, or statin plus ezetimibe, and decreased with the triple combination of colesevelam, statin, and niacin. Colesevelam offset the negative glycemic effects of statins and niacin in subjects with insulin resistance or impaired glucose tolerance. Colesevelam was generally well tolerated when added to other lipid-lowering therapies in clinical trials, with gastrointestinal effects such as constipation being the predominant adverse events. Since colesevelam is not absorbed and works primarily in the intestine, it has a low potential for systemic metabolic drug-drug interactions with other drugs. Colesevelam has been shown to not interact with the lipid-lowering drugs lovastatin and fenofibrate; where interaction may be anticipated, separating dosing times by 4 h reduces the impact of any interaction. Available data confirms that colesevelam has additive cholesterol-lowering effects when used in combination with other lipid-lowering therapies. Furthermore, in some patient populations, the additional glucose-lowering effect of colesevelam may be beneficial in offsetting hyperglycemic effects of other lipid-lowering drugs.
- American journal of cardiovascular drugs : drugs, devices, and other interventions.Am J Cardiovasc Drugs.2013 Oct;13(5):315-23. doi: 10.1007/s40256-013-0037-0.
- Hyperlipidemia is associated with an increased risk of cardiovascular events; reducing low-density lipoprotein cholesterol (LDL-C), the primary target for cholesterol-lowering therapy, lowers the risk for such events. Although bile acid sequestrants were the first class of drugs to show a mortality
- PMID 23913404
Japanese Journal
- 陰イオン交換樹脂コレスチミドを用いた過敏性腸症候群の治療 (特集 過敏性腸症候群の病態と診療)
- Colestimide improves glycemic control via hepatic glucose production in db/db mice
- Yamakawa Tadashi,Ogihara Kikumi,Utsunomiya Hirotoshi,Muraoka Tomonori,Kadonosono Kazuaki,Terauchi Yasuo
- Endocrine Journal 61(5), 425-436, 2014
- … The objective of this study was to assess the chronic effects of a bile acid sequestrant, colestimide, on glucose metabolism. …
- NAID 130004443964
- A Strontium-90 Sequestrant for First-Aid Treatment of Radiation Emergency
- Haratake Mamoru,Hatanaka Eisuke,Fuchigami Takeshi [他],Akashi Makoto,Nakayama Morio
- Chemical and Pharmaceutical Bulletin 60(10), 1258-1263, 2012
- … In this study, hydrophilic porous polymer beads with phosphonic acid groups (PGMA-EGDMA-TTA-MP) were synthesized, and assessed as a radioactive strontium-90 sequestrant for the treatment of the radiation emergency. …
- NAID 130001852358
Related Links
- sequestrant third-person plural present active indicative of sequestr ō Retrieved from "https://en.wiktionary.org/w/index.php?title=sequestrant&oldid=36421459" Categories: English lemmas English nouns English countable nouns ...
- se·ques·trant (sĭ-kwĕs′trənt) n. A chemical that promotes sequestration. sequestrant (sɪˈkwɛstrənt) n (Horticulture) chem any substance used to bring ... In the second phase of our study, we are investigating whether treatment with ...
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- 関
- sequestrant