Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/06/07 11:22:06」(JST)

wiki en

A seborrheic keratosis is a non-cancerous (benign) skin tumour that originates from cells in the outer layer of the skin. Like liver spots, seborrheic keratoses are seen more often as people age.^[4]

The tumours (also called lesions) appear in various colours, from light tan to black. They are round or oval, feel flat or slightly elevated, like the scab from a healing wound, and range in size from very small to more than 2.5 centimetres (1 in) across.^[5] They can often come in association with other skin conditions, including basal cell carcinoma.^[6] Sometimes seborrheic keratosis and basal cell carcinoma occur at the same location, and sometimes seborrheic keratosis progresses to basal cell carcinoma. At clinical examination the differential diagnosis includes warts^[4] and melanoma. Because only the top layers of the epidermis are involved, seborrheic keratoses are often described as having a "pasted on" appearance. Some dermatologists refer to seborrheic keratoses as "seborrheic warts", because they resemble warts, but strictly speaking the term "warts" refers to lesions that are caused by human papillomavirus.^[7]

Cause

The cause of seborrheic keratosis is not known.^[4]

Diagnosis

Micrograph of a seborrheic keratosis (H&E stain, scanning magnification)

Visual diagnosis is made by the "stuck on" appearance, horny pearls or cysts embedded in the structure. Darkly pigmented lesions can be challenging to distinguish from nodular melanomas.^[8] Furthermore, thin seborrheic keratoses on facial skin can be very difficult to differentiate from lentigo maligna even with dermatoscopy. Clinically, epidermal nevi are similar to seborrheic keratoses in appearance. Epidermal nevi are usually present at or near birth. Condylomas and warts can clinically resemble seborrheic keratoses, and dermatoscopy can be helpful. On the penis and genital skin, condylomas and seborrheic keratoses can be difficult to differentiate, even on biopsy.^{[citation needed]}

A study examining over 4000 biopsied skin lesions identified as seborrheic keratoses showed 3.1% were malignancies. Two-thirds of those were squamous cell carcinoma.^[9] To date, the gold standard in the diagnosis of seborrheic keratosis is represented by the histolopathologic analysis of a skin biopsy.^[10]

Classification

Seborrheic keratoses may be divided into the following types:^[2]^:769–770^[11]^[12]^[13]

Common seborrheic keratosis (basal cell papilloma, solid seborrheic keratosis)
Reticulated seborrheic keratosis (adenoid seborrheic keratosis)
Stucco keratosis (digitate seborrheic keratosis, hyperkeratotic seborrheic keratosis, serrated seborrheic keratosis, verrucous seborrheic keratosis) -- Often are light brown to off-white. Pinpoint to a few millimeters in size. Often found on the distal tibia, ankle, and foot.
Clonal seborrheic keratosis
Irritated seborrheic keratosis (inflamed seborrheic keratosis)
Seborrheic keratosis with squamous atypia
Melanoacanthoma (pigmented seborrheic keratosis)
Dermatosis papulosa nigra—Commonly found among adult dark-skinned individuals, presents on the face as small benign papules from a pinpoint to a few millimeters in size.
Inverted follicular keratosis

Treatment

No treatment of seborrheic keratoses is necessary, except for aesthetic reasons.^[4] Generally, lesions can be treated with electrodesiccation and curettage, or cryosurgery. When correctly performed, removal of seborrheic keratoses will not cause much visible scarring.^[14]

Epidemiology

Seborrheic keratosis is the most common benign skin tumor. Incidence increases with age. There is less prevalence in people with darker skin.^[15] In large-cohort studies, 100% of the patients over age 50 had at least one seborrheic keratosis.^[16] Onset is usually in middle age, although they are common in younger patients too—found in 12% of 15-year-olds to 25-year-olds—making the term "senile keratosis" a misnomer.^[17]

References

^ Hafner, C; Vogt, T (Aug 2008). "Seborrheic keratosis". Journal der Deutschen Dermatologischen Gesellschaft. 6 (8): 664–77. doi:10.1111/j.1610-0387.2008.06788.x. PMID 18801147.
^ ^a ^b Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
^ ^a ^b ^c ^d Moles, Freckles, Skin Tags, Benign Lentigines, and Seborrheic Keratoses Archived 2015-05-22 at the Wayback Machine from the Cleveland Clinic website
^ Seborrheic keratosis: Symptoms Archived 2008-09-24 at the Wayback Machine, from the Mayo Clinic website
^ Fusco, N.; Lopez, G.; Gianelli, U. (2015). "Basal Cell Carcinoma and Seborrheic Keratosis: When Opposites Attract". International Journal of Surgical Pathology. 23 (6): 464. doi:10.1177/1066896915593802. PMID 26135529.
^ Reutter, Jason C.; Geisinger, Kim R.; Laudadio, Jennifer (2014). "Vulvar Seborrheic Keratosis". Journal of Lower Genital Tract Disease. 18 (2): 190–4. doi:10.1097/LGT.0b013e3182952357. PMID 24556611.
^ "Heartburn". ssai-starss.com. Archived from the original on 22 February 2014. Retrieved 7 May 2018.
^ Chen, Tiffany Y.; Morrison, Annie O.; Cockerell, Clay J. (2017-09-01). "Cutaneous malignancies simulating seborrheic keratoses: An underappreciated phenomenon?". Journal of Cutaneous Pathology. 44 (9): 747–748. doi:10.1111/cup.12975. ISSN 1600-0560. PMID 28589622.
^ Hanlon, Allison (2018). A Practical Guide to Skin Cancer. Springer. p. 80. ISBN 9783319749037. Retrieved 22 September 2018.
^ Busam, Klaus J. (2010). Dermatopathology. Saunders. p. 341. ISBN 978-0-443-06654-2.
^ Dermatosis Papulosa Nigra at eMedicine
^ Stucco Keratosis at eMedicine
^ "Seborrheic keratoses | American Academy of Dermatology". www.aad.org. American Academy of Dermatology. Retrieved 22 September 2018.
^ Zhang, Ru-Zhi; Zhu, Wen-Yuan (2011). "Seborrheic keratoses in five elderly patients: An appearance of raindrops and streams". Indian Journal of Dermatology. 56 (4): 432–434. doi:10.4103/0019-5154.84754. PMC 3179013. PMID 21965858.
^ Yeatman JM, Kilkenny M, Marks R (Sep 1997). "The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency?". Br J Dermatol. 137 (3): 411–4. doi:10.1111/j.1365-2133.1997.tb03748.x. PMID 9349339.
^ Gill D, Dorevitch A, Marks R (Jun 2000). "The prevalence of seborrheic keratoses in people aged 15 to 30 years: is the term senile keratosis redundant?". Arch Dermatol. 136 (6): 759–62. doi:10.1001/archderm.136.6.759. PMID 10871940.

External links

DermAtlas 185

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 皮膚疣贅（尋常性疣贅、足底疣贅、扁平疣贅）cutaneous warts common plantar and flat warts [show details]
… thrombosed capillaries within plantar warts Unlike warts, the dark color can be removed by superficial paring and skin lines are not disrupted. Seborrheic keratosis – Seborrheic keratoses are papules or plaques …
2. 皮膚の良性病変の概要overview of benign lesions of the skin [show details]
… present in inflamed or irritated lesions. Seborrheic keratoses should be differentiated from other benign and malignant lesions, including acrochordon, verruca vulgaris, epidermal nevi, melanocytic nevi, basal …
3. Minor dermatologic proceduresminor dermatologic procedures [show details]
… considered cosmetic. Lesions that can be treated in this matter include seborrheic keratoses, sebaceous hyperplasia, and verrucae. Some lesions can be treated with electrodesiccation alone, including skin …
4. 活動的な小児や骨格発達の未成熟な青年の踵痛：原因の概要heel pain in the active child or skeletally immature adolescent overview of causes [show details]
…discussed in detail separately. Plantar warts commonly occur on pressure points in the heel and the ball of the foot. Overlying callus may cause pain. On inspection, plantar warts appear as hyperkeratotic papules …
5. 活動的な小児や骨格発達の未成熟な青年の前足部および中足部の痛み：原因の概要forefoot and midfoot pain in the active child or skeletally immature adolescent overview of causes [show details]
…discussed in detail separately. Plantar warts commonly occur on pressure points in the ball of the foot and the heel. Overlying callus may cause pain. On inspection, plantar warts appear as hyperkeratotic papules …

English Journal

Diffuse lichen planus-like keratoses and clinical pseudo-progression associated with avelumab treatment for Merkel cell carcinoma, a case report.

Cardis MA, Jiang H, Strauss J, Gulley JL, Brownell I.
BMC cancer. 2019 Jun;19(1)539.
Avelumab is an anti-programmed cell death ligand 1 (PD-L1) antibody approved for treatment of Merkel cell carcinoma (MCC) and locally advanced or metastatic urothelial carcinoma. It shares a similar side effect profile to other immune checkpoint inhibitors, including immune-related adverse reactions
PMID 31164102

Fibroblast Growth Factor Receptor Signaling in Skin Cancers.

, C C, M M, M M.
Cells. 2019 Jun;8(6).
Fibroblast growth factor (FGF)/Fibroblast growth factor receptor (FGFR) signaling regulates various cellular processes during the embryonic development and in the adult organism. In the skin, fibroblasts and keratinocytes control proliferation and survival of melanocytes in a paracrine manner via se
PMID 31167513

Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern.

Roy SF, Ko CJ, Moeckel GW, McNiff JM.
Journal of cutaneous pathology. 2019 Jun;().
Hypergranulotic dyscornification (HD) is a rarely reported histologic reaction pattern that may be observed in solitary benign keratoses. We retrospectively reviewed all cases described as displaying 'hypergranulotic dyscornification' at our institution between January 1 1990 to September 1 2018. We
PMID 31157457

Japanese Journal

ゆうぜい状表皮発育異常症

村上義之,永江祥之介,今福信一,古江増隆,入江康司
西日本皮膚科 60(4), 454-458, 1998
症例は40歳の男性。両下眼瞼の黒色小結節を主訴に佐賀県立病院好生館皮膚科を受診した。四肢·躯幹には扁平疣贅様皮疹, 癜風様皮疹が混在していた。臨床的, 病理組織学的所見から疣贅状表皮発育異常症(epidermodysplasia verruciformis)と診断した。下眼瞼の結節は脂漏性角化症と考え, 液体窒素凍結療法を施行した。他部位に悪性を思わせる皮疹は認められず, 臨床検査成 …
NAID 130004474432

「脂漏性角化症」

Classification	D ICD-10: L82; ICD-9-CM: 702.1; OMIM: 182000; MeSH: D017492; DiseasesDB: 29386;
External resources	MedlinePlus: 000884; eMedicine: derm/397;

Seborrheic keratosis
Other names	Seborrheic verruca, basal cell papilloma, senile wart,
	Multiple seborrheic keratoses on the dorsum of a patient with Leser–Trélat sign.
Specialty	Dermatology

　　[★]

英: seborrheic keratosis, SK
同: 老人性疣贅 senile wart verruca senilis　老人性ゆうぜい、脂漏性疣贅 seborrheic wart
関: Leser-Trelat徴候

「war」

　　[★]

戦争、戦い

関: combat、warfare

「seborrheic」

　　[★]

adj.

脂漏性の

関: seborrhea; seborrhoic

[1] Hafner, C; Vogt, T (Aug 2008). "Seborrheic keratosis". Journal der Deutschen Dermatologischen Gesellschaft. 6 (8): 664–77. doi:10.1111/j.1610-0387.2008.06788.x. PMID 18801147.

[Fitz2-2] Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.

[Andrews-3] James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.

[cleve-4] Moles, Freckles, Skin Tags, Benign Lentigines, and Seborrheic Keratoses Archived 2015-05-22 at the Wayback Machine from the Cleveland Clinic website

[mayosymp-5] Seborrheic keratosis: Symptoms Archived 2008-09-24 at the Wayback Machine, from the Mayo Clinic website

[6] Fusco, N.; Lopez, G.; Gianelli, U. (2015). "Basal Cell Carcinoma and Seborrheic Keratosis: When Opposites Attract". International Journal of Surgical Pathology. 23 (6): 464. doi:10.1177/1066896915593802. PMID 26135529.

[7] Reutter, Jason C.; Geisinger, Kim R.; Laudadio, Jennifer (2014). "Vulvar Seborrheic Keratosis". Journal of Lower Genital Tract Disease. 18 (2): 190–4. doi:10.1097/LGT.0b013e3182952357. PMID 24556611.

[8] "Heartburn". ssai-starss.com. Archived from the original on 22 February 2014. Retrieved 7 May 2018.

[9] Chen, Tiffany Y.; Morrison, Annie O.; Cockerell, Clay J. (2017-09-01). "Cutaneous malignancies simulating seborrheic keratoses: An underappreciated phenomenon?". Journal of Cutaneous Pathology. 44 (9): 747–748. doi:10.1111/cup.12975. ISSN 1600-0560. PMID 28589622.

[10] Hanlon, Allison (2018). A Practical Guide to Skin Cancer. Springer. p. 80. ISBN 9783319749037. Retrieved 22 September 2018.

[11] Busam, Klaus J. (2010). Dermatopathology. Saunders. p. 341. ISBN 978-0-443-06654-2.

[12] Dermatosis Papulosa Nigra at eMedicine

[13] Stucco Keratosis at eMedicine

[14] "Seborrheic keratoses | American Academy of Dermatology". www.aad.org. American Academy of Dermatology. Retrieved 22 September 2018.

[Zhang2011-15] Zhang, Ru-Zhi; Zhu, Wen-Yuan (2011). "Seborrheic keratoses in five elderly patients: An appearance of raindrops and streams". Indian Journal of Dermatology. 56 (4): 432–434. doi:10.4103/0019-5154.84754. PMC 3179013. PMID 21965858.

[16] Yeatman JM, Kilkenny M, Marks R (Sep 1997). "The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency?". Br J Dermatol. 137 (3): 411–4. doi:10.1111/j.1365-2133.1997.tb03748.x. PMID 9349339.

[17] Gill D, Dorevitch A, Marks R (Jun 2000). "The prevalence of seborrheic keratoses in people aged 15 to 30 years: is the term senile keratosis redundant?". Arch Dermatol. 136 (6): 759–62. doi:10.1001/archderm.136.6.759. PMID 10871940.

リンク元	「脂漏性角化症」
関連記事	「war」「seborrheic」

匿名

検索

案内

案内

seborrheic wart