WordNet

used to signify the Union forces in the American Civil War (who wore blue uniforms); "a ragged blue line"
blue color or pigment; resembling the color of the clear sky in the daytime; "he had eyes of bright blue" (同)blueness
any of numerous small butterflies of the family Lycaenidae
blue clothing; "she was wearing blue"
any organization or party whose uniforms or badges are blue; "the Union army was a vast blue"
of the color intermediate between green and violet; having a color similar to that of a clear unclouded sky; "Octobers bright blue weather"- Helen Hunt Jackson; "a blue flame"; "blue haze of tobacco smoke" (同)bluish, blueish
causing dejection; "a blue day"; "the dark days of the war"; "a week of rainy depressing weather"; "a disconsolate winter landscape"; "the first dismal dispiriting days of November"; "a dark gloomy day"; "grim rainy weather" (同)dark, dingy, disconsolate, dismal, gloomy, grim, sorry, drab, drear, dreary
suggestive of sexual impropriety; "a blue movie"; "blue jokes"; "he skips asterisks and gives you the gamy details"; "a juicy scandal"; "a naughty wink"; "naughty words"; "racy anecdotes"; "a risque story"; "spicy gossip" (同)gamy, gamey, juicy, naughty, racy, risque, spicy
morally rigorous and strict; "the puritan work ethic"; "puritanic distaste for alcohol"; "she was anything but puritanical in her behavior" (同)puritanic, puritanical
turn blue
turbulent water with swells of considerable size; "heavy seas"
a division of an ocean or a large body of salt water partially enclosed by land
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
a state of depression; "he had a bad case of the blues" (同)blue devils, megrims, vapors, vapours
a type of folksong that originated among Black Americans at the beginning of the 20th century; has a melancholy sound from repeated use of blue notes
a process that makes something blue (or bluish) (同)blueing
used to whiten laundry or hair or give it a bluish tinge (同)blueing, blue

PrepTutorEJDIC

『青い』,あい色の / 青黒い / 《話》陰気な,憂うつな / 〈U〉『青色』,あい色;青色の着物 / 〈U〉〈C〉青色絵の具,あい色染料 / 《the~》《詩》青空,青い海 / 《the blues》《話》気のふさぎ,うれいの色 / 《the blues》《ときに単数扱い》(ジャズ音楽の)ブルース / …'を'青色にする
《通例the~》《しばしば複数形で単数扱い》『海』,海洋 / 〈C〉《固有名詞につけるときはS-》(部分的に陸地に囲まれた)海,…海 / (波の状態から見た)海面,湖面,水面;(海・湖などの)波;大波,高波 / 〈U〉《the ~》船乗り(水兵)の仕事,海上生活 / 《a ~》大量(の…),たくさん(の…)《+『of』+『名』》
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/23 04:14:08」(JST)

wiki en

Sea-blue histiocytosis is a cutaneous condition that may occur as a familial inherited syndrome or as an acquired secondary or systemic infiltrative process.^[1]^:720

Causes

It can be associated with the gene APOE.^[2]

It can also be acquired.^[3] Sea-blue histiocyte syndrome is seen in patients receiving fat emulsion as a part of long-term parenteral nutrition (TPN) for intestinal failure.

Pathophysiology and presentation

The high lipid content in the blood leads to excessive cytoplasm loading of lipids within histiocytes.

The subsequent incomplete degradation of these lipids leads to the formation of cytoplasmic lipid pigments.

High lipid content may also cause membrane abnormality of the hemopoietic cells which is recognized by macrophages and therefore, increased accumulation within the bone marrow.

These lipid laden histiocytes appear blue with May-Giemsa^[4]/PAS stain hence the name of Sea-Blue Histocyte Syndrome. Sea-blue histiocytosis is also seen in lipid disorders.

References

^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ Faivre L, Saugier-Veber P, Pais de Barros JP, et al (November 2005). "Variable expressivity of the clinical and biochemical phenotype associated with the apolipoprotein E p.Leu149del mutation". Eur. J. Hum. Genet. 13 (11): 1186–91. doi:10.1038/sj.ejhg.5201480. PMID 16094309.
^ Candoni A, Grimaz S, Doretto P, Fanin R, Falcomer F, Bembi B (October 2001). "Sea-blue histiocytosis secondary to Niemann-Pick disease type B: a case report". Ann. Hematol. 80 (10): 620–2. doi:10.1007/s002770100354. PMID 11732877.
^ Suzuki O, Abe M (April 2007). "Secondary sea-blue histiocytosis derived from Niemann-Pick disease" (^{[dead link]}). J Clin Exp Hematop 47 (1): 19–21. doi:10.3960/jslrt.47.19. PMID 17510534.

UpToDate Contents

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1. 骨髄穿刺塗抹標本の評価 evaluation of bone marrow aspirate smears
2. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia
3. ニーマン・ピック病の概要 overview of niemann pick disease

English Journal

Fish Oil Lipid Emulsion-Associated Sea-Blue Histiocyte Syndrome in a Pediatric Patient.

Wu TT1, Hoff DS1.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG.J Pediatr Pharmacol Ther.2015 May-Jun;20(3):217-21. doi: 10.5863/1551-6776-20.3.217.
A syndrome of hepatosplenomegaly, thrombocytopenia, and anemia and the presence of sea-blue histiocytes in bone marrow has been associated with parenteral soybean oil administration in patients receiving long-term total parenteral nutrition (TPN). A case is described here where this syndrome was obs
PMID 26170774

Sea-blue histiocytosis in bone marrow of a patient with chronic thrombocytopenia.

Bermejo N1, Prieto J, Arcos MJ.
Acta haematologica.Acta Haematol.2015;133(3):277-8. doi: 10.1159/000366189. Epub 2014 Nov 20.
PMID 25413372

Very prolonged liposomal amphotericin B use leading to a lysosomal storage disease.

Michot JM1, Gubavu C2, Fourn E2, Maigne G3, Teicher E2, Angoulvant A4, Blanche S5, Lortholary O6, Coilly A7, Duclos-Vallée JC7, Sebagh M8, Guettier C8, Aumont C9, Delfraissy JF3, Lambotte O3.
International journal of antimicrobial agents.Int J Antimicrob Agents.2014 Jun;43(6):566-9. doi: 10.1016/j.ijantimicag.2014.02.015. Epub 2014 Apr 12.
Amphotericin B is a powerful polyene antifungal drug used for treating systemic fungal infections and is usually administered for a short period. Side effects after prolonged use are unknown in humans. Here we report the case of a 28-year-old man suffering from chronic granulomatous disease (CGD), t
PMID 24787480

Japanese Journal

Syndrome of the Sea-Blue Histiocyte

HIRAYAMA Yasuo,KOHDA Kyuhei,ANDOH Masakatsu,MATSUMOTO Syuji,NAKAZAWA Osamu,NOBUOKA Atsushi,MOCHIZUKI Chihiro,TAKAYANAGI Norihiro,EZOE Ayano
Internal medicine 35(5), 419-421, 1996-05
… These histiocytes were closely packed with granules, dyed sea-blue with May-Giemsa staining. … Further microscopical examination of lymph nodes, gastro-intestinal tract and bone marrow also revealed the accumulation of sea-blue histiocytes. … Activities of lipid metabolic enzymes were normal and hematopoietic diseases which are sometimes accompanied by secondary sea-blue histiocytosis were ruled out. …
NAID 10007003146