分裂赤血球
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/18 19:14:42」(JST)
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Peripheral blood (MGG stain): patient with hemolytic-uremic syndrome
A schistocyte or schizocyte (from Greek schistos for "divided" or schistein for "to split", and kytos for "hollow" or "cell") is a fragmented part of a red blood cell. Schistocytes are typically irregularly shaped, jagged, and have two pointed ends. A true schistocyte does not have central pallor. [1] Schistocytes are sometimes referred to as "helmet cells".
Several microangiopathic diseases, including disseminated intravascular coagulation and thrombotic microangiopathies, generate fibrin strands that sever red blood cells as they try to move past a thrombus, creating schistocytes.
Schistocytes are often seen in patients with hemolytic anemia. They are frequently a consequence of mechanical artificial heart valves and hemolytic uremic syndrome, among other causes.
Excessive schistocytes present in blood can be a sign of microangiopathic hemolytic anemia (MAHA) where the most common cause is aortic stenosis.
References[edit source | edit]
- ^ Amanda Cox et al., Schistocytes: A Brief Overview. Retrieved 23 August 2008.
External links[edit source | edit]
- Images in Clinical Medicine: Hemolytic Anemia after Mitral-Valve Repair, Sarinya Puwanant and Watchara Lohawijarn, N Engl J Med 2012; 367:e29 (November 15, 2012) DOI: 10.1056/NEJMicm1201695 [FREE TEXT]
Abnormal clinical and laboratory findings for blood tests (R70–R79, 790)
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Red blood cells |
Size
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- Anisocytosis
- Macrocyte
- Microcyte
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Shape
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- membrane abnormalities: Acanthocyte
- Codocyte
- Ovalocyte
- Spherocyte
- other: Dacrocyte
- Echinocyte
- Schistocyte
- Degmacyte
- Drepanocyte
- Stomatocyte
- Knizocyte
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Hemoglobinization
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Inclusion bodies
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- developmental organelles (Howell-Jolly body, Basophilic stippling, Pappenheimer bodies, Cabot rings)
- abnormal hemoglobin precipitation (Heinz body)
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Other
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- Rouleaux
- Reticulocyte
- Elevated ESR
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Lymphocytes |
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Small molecules |
Blood sugar
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- Hypoglycemia
- Hyperglycemia
- Prediabetes (Impaired fasting glucose, Impaired glucose tolerance)
- Oxyhyperglycemia
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Nitrogenous
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- Azotemia
- Hyperuricemia
- Hypouricemia
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Proteins |
LFT
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- Elevated transaminases
- Elevated ALP
- Hypoproteinemia (Hypoalbuminemia)
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Other
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- Elevated cardiac markers
- Elevated alpha-fetoprotein
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Minerals |
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Pathogens/sepsis |
- Bacteremia
- Viremia
- Fungemia
- Parasitemia
- Algaemia
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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noco/acba/cong/tumr, sysi/epon, urte
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proc/itvp, drug (G4B), blte, urte
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UpToDate Contents
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…many 1000-fold until mature tissue schizonts are formed, each containing thousands of daughter merozoites. This exoerythrocytic stage is asymptomatic. The liver schizonts rupture after 6 to 30 days; 98 percent …
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…the liver, where they invade hepatocytes, undergo asexual replication, and develop into schizonts. Hepatic schizonts rupture and release thousands of daughter merozoites into the bloodstream, causing fever …
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…ingests and degrades hemoglobin and develops through the stages of rings, trophozoites and schizonts. Mature schizonts burst to release merozoites which invade new red cells. A small proportion of merozoites…
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…Primaquine has activity against many stages of the malaria parasite including hypnozoites, tissue schizonts, gametocytes, and asexual blood stages of P. vivax . It is useful for preventing relapses from …
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…the first growth cycle but a markedly reduced number of ring forms following the schizont stage, with degenerated schizonts observed on day 4. This defect was not affected by deoxygenation or an increase …
English Journal
- Third-party mesenchymal stromal cell infusion is associated with a decrease in thrombotic microangiopathy symptoms observed post-hematopoietic stem cell transplantation.
- Ansari M1, Strunk D, Schallmoser K, Delcò C, Rougemont AL, Moll S, Villard J, Gumy-Pause F, Chalandon Y, Parvex P, Passweg J, Ozsahin H, Kindler V.
- Pediatric transplantation.Pediatr Transplant.2012 Mar;16(2):131-6. doi: 10.1111/j.1399-3046.2011.01621.x. Epub 2011 Dec 7.
- TA-TMA is a pathology that occurs after allogenic HSC transplantation with an incidence of 4-13%, and represents one of the most severe vascular damage related with this therapy. We report here the case of a nine-yr-old girl suffering from a severe refractory aplastic anemia who received an unrelate
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- Evaluation of point-of-care tests for diagnosis of disseminated intravascular coagulation in dogs admitted to an intensive care unit.
- Bateman SW1, Mathews KA, Abrams-Ogg AC, Lumsden JH, Johnstone IB, Hillers TK.
- Journal of the American Veterinary Medical Association.J Am Vet Med Assoc.1999 Sep 15;215(6):805-10.
- OBJECTIVE: To evaluate the accuracy of point-of-care tests for the diagnosis of disseminated intravascular coagulation (DIC) in dogs and assess the correlation and agreement of results between point-of-care and laboratory tests in the evaluation of hemostatic function.DESIGN: Prospective case series
- PMID 10496132
Japanese Journal
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Related Links
- schistocyte [shis´-, skis´to-sīt] a fragment of an erythrocyte, commonly observed in the blood in hemolytic anemia; called also helmet cell and schizocyte. schis·to·cyte (skis'tō-sīt), A variety of poikilocyte that owes its abnormal ...
- Define schizocyte. schizocyte synonyms, schizocyte pronunciation, schizocyte translation, English dictionary definition of schizocyte. n. A red blood cell having an abnormal shape as a result of fragmentation that occurs as the ...
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