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a weak protease inhibitor (trade name Invirase) used in treating HIV (同)Invirase

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Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier.

Tomi M, Nishimura T, Nakashima E.SourceFaculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan. tomi-ms@pha.keio.ac.jp.
Journal of pharmaceutical sciences.J Pharm Sci.2011 Sep;100(9):3708-18. doi: 10.1002/jps.22642. Epub 2011 May 29.
Administration of antiviral drugs to pregnant women with influenza, human immunodeficiency virus (HIV), and herpes simplex virus (HSV) infections is widely accepted as an effective treatment to safeguard the health of the mother and fetus. This review deals with the transfer of antiviral drugs to th
PMID 21626508

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: A case study with saquinavir.

Brouwers J, Vermeire K, Grammen C, Schols D, Augustijns P.SourceLaboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Leuven, Belgium.
Antiviral research.Antiviral Res.2011 Aug;91(2):217-23. Epub 2011 Jun 6.
In the search for a successful HIV microbicide, many poorly water-soluble antiviral agents are currently being investigated. Unfortunately, solubility and precipitation issues may limit intravaginal concentrations and thus availability of these agents upon application of an aqueous gel formulation.
PMID 21683096