Ticks and tick-borne diseases.Ticks Tick Borne Dis.2016 Apr;7(3):487-97. doi: 10.1016/j.ttbdis.2016.02.005. Epub 2016 Feb 17.
Ticks and tick-borne diseases are among the main causes of economic loss in the South African cattle industry through high morbidity and mortality rates. Concerns of the general public regarding chemical residues may tarnish their perceptions of food safety and environmental health when the husbandr
Electrophoresis.Electrophoresis.2016 Mar 16. doi: 10.1002/elps.201500573. [Epub ahead of print]
Holder pasteurization (62.5°C, 30 min) ensures sanitary quality of donor's human milk but also denatures beneficial proteins. Understanding whether this further impacts the kinetics of peptide release during gastrointestinal digestion of human milk was the aim of the present paper. Mature raw (RHM)
Green Tea Extract Affects the Cytochrome P450 3A Activity and Pharmacokinetics of Simvastatin in Rats
MISAKA Shingen,KAWABE Keisuke,ONOUE Satomi,WERBA José Pablo,GIROLI Monica,WATANABE Hiroshi,YAMADA Shizuo
Drug Metabolism and Pharmacokinetics 28(6), 514-518, 2013
… Inhibitory effects of GTE on CYP3A activity were investigated in rat hepatic microsomes (RHM) using midazolam (MDZ) 1′-hydroxylation as a probe reaction. … Plasma concentrations of SIM and its active metabolite, simvastatin acid, were determined up to 6 h after the SIM administration using LC/MS/MS. In RHM, GTE inhibited MDZ 1′-hydroxylation with IC50 and Kiapp values of 12.5 and 18.8 µg/mL, respectively, in a noncompetitive manner. …