レチノイドX受容体γ
WordNet
- a unit of magnetic field strength equal to one-hundred-thousandth of an oersted
- the 3rd letter of the Greek alphabet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the 24th letter of the Roman alphabet (同)x, ex
- a herd of whales
PrepTutorEJDIC
- ガンマ(ギリシア語アルファベットの第3字Γ,γ;英語のG,gに相当)
- =sense organ / 受信装置
- Christ / Christian
- (特に女性の)魅力的な脚,すんなりした脚
- x-axis
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/26 17:44:55」(JST)
[Wiki en表示]
Retinoid X receptor, gamma |
Crystallographic structure of the DNA-binding domain of the Retinoid X receptor, gamma. PDB rendering based on 1by4. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
2GL8
|
|
|
Identifiers |
Symbols |
RXRG ; NR2B3; RXRC |
External IDs |
OMIM: 180247 MGI: 98216 HomoloGene: 21373 IUPHAR: NR2B3 ChEMBL: 2004 GeneCards: RXRG Gene |
Gene ontology |
Molecular function |
• steroid hormone receptor activity
• 9-cis retinoic acid receptor activity
• zinc ion binding
• sequence-specific DNA binding
|
Cellular component |
• nucleoplasm
|
Biological process |
• transcription initiation from RNA polymerase II promoter
• peripheral nervous system development
• heart development
• skeletal muscle tissue development
• gene expression
• neuron differentiation
• regulation of myelination
• response to retinoic acid
• positive regulation of transcription from RNA polymerase II promoter
|
Sources: Amigo / QuickGO |
|
RNA expression pattern |
|
More reference expression data |
Orthologs |
Species |
Human |
Mouse |
|
Entrez |
6258 |
20183 |
|
Ensembl |
ENSG00000143171 |
ENSMUSG00000015843 |
|
UniProt |
P48443 |
P28705 |
|
RefSeq (mRNA) |
NM_001256570 |
NM_001159731 |
|
RefSeq (protein) |
NP_001243499 |
NP_001153203 |
|
Location (UCSC) |
Chr 1:
165.37 – 165.41 Mb |
Chr 1:
167.6 – 167.64 Mb |
|
PubMed search |
[1] |
[2] |
|
|
Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.[1][2]
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
Contents
- 1 See also
- 2 Interactions
- 3 References
- 4 Further reading
See also
Interactions
Retinoid X receptor gamma has been shown to interact with ITGB3BP.[3]
References
- ^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
- ^ a b "Entrez Gene: RXRG retinoid X receptor, gamma".
- ^ Li, D; Wang F, Samuels H H (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMC 100002. PMID 11713274.
Further reading
- Szanto A, Narkar V, Shen Q, et al. (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions.". Cell Death Differ. 11 Suppl 2: S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.
- Leid M, Kastner P, Lyons R, et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.". Cell 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.
- Mangelsdorf DJ, Borgmeyer U, Heyman RA, et al. (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.". Genes Dev. 6 (3): 329–44. doi:10.1101/gad.6.3.329. PMID 1312497.
- Nagata T, Weiss EH, Abe K, et al. (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human.". Immunogenetics 41 (2–3): 83–90. doi:10.1007/BF00182317. PMID 7806300.
- Muscat GE, Mynett-Johnson L, Dowhan D, et al. (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. doi:10.1093/nar/22.4.583. PMC 307847. PMID 8127707.
- Kamei Y, Xu L, Heinzel T, et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Sanno N, Sugawara A, Teramoto A, et al. (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology 65 (4): 299–306. doi:10.1159/000127188. PMID 9143002.
- Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. doi:10.1023/A:1026481205135. PMID 9147069.
- Xu XC, Sozzi G, Lee JS, et al. (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186.
- Yusta B, Alarid ET, Gordon DF, et al. (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology 139 (11): 4476–82. doi:10.1210/en.139.11.4476. PMID 9794455.
- Ito K, Suzuki T, Moriya T, et al. (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. doi:10.1210/jc.86.6.2721. PMID 11397877.
- Kim SW, Kim HJ, Jung DJ, et al. (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene 20 (45): 6638–42. doi:10.1038/sj.onc.1204695. PMID 11641790.
- Brabender J, Danenberg KD, Metzger R, et al. (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661.
- Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. doi:10.1074/jbc.M203572200. PMID 12082103.
- Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta 23 (8–9): 661–71. doi:10.1053/plac.2002.0855. PMID 12361685.
- Kimura Y, Suzuki T, Kaneko C, et al. (2003). "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. PMID 12444914.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Alfaro JM, Fraile B, Lobo MV, et al. (2003). "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate". J. Androl. 24 (1): 113–9. PMID 12514092.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery
|
|
|
1by4: STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA
|
|
1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
|
|
1r0n: Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex
|
|
1rxr: HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE
|
|
2gl8: Human Retinoic acid receptor RXR-gamma ligand-binding domain
|
|
2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
|
|
|
|
Transcription factors and intracellular receptors
|
|
(1) Basic domains
|
|
(1.1) Basic leucine zipper (bZIP) |
- Activating transcription factor
- AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
- BACH
- BATF
- BLZF1
- C/EBP
- CREB
- CREM
- DBP
- DDIT3
- GABPA
- HLF
- MAF
- NFE
- NFIL3
- NRL
- NRF
- XBP1
|
|
(1.2) Basic helix-loop-helix (bHLH) |
- ATOH1
- AhR
- AHRR
- ARNT
- ASCL1
- BHLH
- ARNTL
- CLOCK
- EPAS1
- FIGLA
- HAND
- HES
- HEY
- HES1
- HIF
- ID
- LYL1
- MESP2
- MXD4
- MYCL1
- MYCN
- Myogenic regulatory factors
- Neurogenins
- NeuroD
- NPAS
- OLIG
- Pho4
- Scleraxis
- SIM
- TAL
- Twist
- USF1
|
|
(1.3) bHLH-ZIP |
- AP-4
- MAX
- MITF
- MNT
- MLX
- MXI1
- Myc
- SREBP
|
|
(1.4) NF-1 |
|
|
(1.5) RF-X |
|
|
(1.6) Basic helix-span-helix (bHSH) |
|
|
|
|
(2) Zinc finger DNA-binding domains
|
|
(2.1) Nuclear receptor (Cys4) |
subfamily 1 |
- Thyroid hormone
- CAR
- FXR
- LXR
- PPAR
- PXR
- RAR
- ROR
- Rev-ErbA
- VDR
|
|
subfamily 2 |
- COUP-TF
- Ear-2
- HNF4
- PNR
- RXR
- Testicular receptor
- TLX
|
|
subfamily 3 |
- Steroid hormone
- Androgen
- Estrogen
- Glucocorticoid
- Mineralocorticoid
- Progesterone
- Estrogen related
|
|
subfamily 4 |
|
|
subfamily 5 |
|
|
subfamily 6 |
|
|
subfamily 0 |
|
|
|
(2.2) Other Cys4 |
|
|
(2.3) Cys2His2 |
|
|
(2.4) Cys6 |
|
|
(2.5) Alternating composition |
- AIRE
- DIDO1
- GRLF1
- ING
- JARID
- JMJD1B
|
|
(2.6) WRKY |
|
|
|
|
(3) Helix-turn-helix domains
|
|
|
|
|
(4) β-Scaffold factors with minor groove contacts
|
|
(4.1) Rel homology region |
- NF-κB
- NFKB1
- NFKB2
- REL
- RELA
- RELB
- NFAT
|
|
(4.2) STAT |
|
|
(4.3) p53 |
- p53
- TBX
- 1
- 2
- 3
- 5
- 19
- 21
- 22
- TBR1
- TBR2
- TFT
- MYRF
- TP63
|
|
(4.4) MADS box |
|
|
(4.6) TATA-binding proteins |
|
|
(4.7) High-mobility group |
- BBX
- HMGB
- HMGN
- HNF
- LEF1
- SOX
- 1
- 2
- 3
- 4
- 5
- 6
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 18
- 21
- SRY
- SSRP1
- TCF
- TOX
|
|
(4.9) Grainyhead |
|
|
(4.10) Cold-shock domain |
|
|
(4.11) Runt |
- CBF
- CBFA2T2
- CBFA2T3
- RUNX1
- RUNX2
- RUNX3
- RUNX1T1
|
|
|
|
(0) Other transcription factors
|
|
(0.2) HMGI(Y) |
|
|
(0.3) Pocket domain |
|
|
(0.5) AP-2/EREBP-related factors |
|
|
(0.6) Miscellaneous |
- ARID
- CAP
- IFI
- MLL
- MNDA
- NFY
- Rho/Sigma
|
|
|
|
see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Epigallocatechin-3-gallate Increases RXRγ-mediated Pro-apoptotic and Anti-invasive Effects in Gastrointestinal Cancer Cell Lines.
- Papi A1, Govoni M, Ciavarella C, Spisni E, Orlandi M, Farabegoli F.
- Current cancer drug targets.Curr Cancer Drug Targets.2016;16(4):373-85.
- Molecules with synergistic effects often enhance the benefits of cancer therapy. We observed that the major catechin of green tea, (-)-Epigallocatechin-3-gallate (EGCG), induced retinoid X receptor-γ (RXRγ) expression in the SK-Ch-A1 cholangiocarcinoma cell line and in two colon carcinoma cell lin
- PMID 26278714
- Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
- de la Fuente AG1, Errea O1, van Wijngaarden P2, Gonzalez GA1, Kerninon C3, Jarjour AA4, Lewis HJ5, Jones CA5, Nait-Oumesmar B3, Zhao C1, Huang JK6, ffrench-Constant C4, Franklin RJ7.
- The Journal of cell biology.J Cell Biol.2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119.
- The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear
- PMID 26644513
- Regulation of Retinoic Acid Receptor Beta by Interleukin-15 in the Lung during Cigarette Smoking and Influenza Virus Infection.
- Wang J1,2, Liu W1, Marion C1, Singh R1, Andrews N1, Lee CG3, Elias JA3, Dela Cruz CS1.
- American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2015 Dec;53(6):822-33. doi: 10.1165/rcmb.2014-0448OC.
- Virus-induced exacerbations often lead to further impairment of lung function in chronic obstructive pulmonary disease. IL-15 is critical in antiviral immune responses. Retinoic acid (RA) signaling plays an important role in tissue maintenance and repair, particularly in the lung. We studied RA sign
- PMID 25923039
Japanese Journal
- The role of the IL-23/IL-17 axis in the pathogenesis of Graves' disease
- 毛包向性菌状息肉症 (folliculotropic mycosis fungoides) の1例
- Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 25(2), 145-149, 2010-09-15
- NAID 10027731597
- Possible Involvement of p38 MAP Kinase in Retinoid-stimulated Expression of Indian Hedgehog in Prehypertrophic Chondrocytes
- Oral science international : official journal of the Japanese Stomatological Society 5(1), 1-14, 2008-05-01
- NAID 10024185761
Related Links
- The authors report a transcriptional profile of the discrete stages of spontaneous remyelination following toxin-induced focal demyelination in rats. They find an enrichment of retinoid X receptor (RXR) signaling pathways over the course ...
- We next performed ingenuity pathway analysis (IPA) by submitting the list of genes that were differentially expressed between 5 and 14 dpl and between 14 and 28 dpl to elucidate the overall physiology of remyelination ...
★リンクテーブル★
[★]
- 英
- retinoid X receptor gamma
[★]
キサントシン, xanthosine
[★]
γ ガンマ