WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/21 09:32:22」(JST)

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The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor^[1] that is activated by both all-trans retinoic acid and 9-cis retinoic acid.^[2] There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma, encoded by the RARA, RARB, RARG genes, respectively. Each receptor isoform has several splice variants: two- for alpha, four- for beta, and two- for gamma.

As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements known as retinoic acid response elements (RAREs) complexed with corepressor protein. Binding of agonist ligands to RAR results in dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

References

^ Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H (2006). "International Union of Pharmacology. LX. Retinoic acid receptors". Pharmacol Rev 58 (4): 712–25. doi:10.1124/pr.58.4.4. PMID 17132850.
^ Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA (1993). "Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids". Proc Natl Acad Sci USA 90 (1): 30–4. doi:10.1073/pnas.90.1.30. PMC 45593. PMID 8380496.

External links

Retinoic Acid Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.

Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T.SourceDepartment of Pharmacology, University of Illinois at Chicago, 835 S. Wolcott Avenue Room E403 (m/c 868), Chicago, IL 60612, USA; Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. Electronic address: crchow@uic.edu.
Cellular signalling.Cell Signal.2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012. Epub 2013 Jun 29.
p115RhoGEF is a member of a family of Rho-specific guanine nucleotide exchange factors that also contains a regulator of G protein signaling homology domain (RH-RhoGEFs) that serves as a link between Gα13 signaling and RhoA activation. While the mechanism of regulation of p115RhoGEF by Gα13 is bec
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Regulation of macrophage and dendritic cell function by pathogens and through immunomodulation in the avian mucosa.

de Geus ED, Vervelde L.SourceDepartment of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands. Electronic address: e.d.degeus@uu.nl.
Developmental and comparative immunology.Dev Comp Immunol.2013 Nov;41(3):341-51. doi: 10.1016/j.dci.2013.03.008. Epub 2013 Mar 28.
Macrophages (MPh) and dendritic cells (DC) are members of the mononuclear phagocyte system. In chickens, markers to distinguish MPh from DC are lacking, but whether MPh and DC can be distinguished in humans and mice is under debate, despite the availability of numerous markers. Mucosal MPh and DC ar
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Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection.

Chiba E, Tomosada Y, Vizoso-Pinto MG, Salva S, Takahashi T, Tsukida K, Kitazawa H, Alvarez S, Villena J.SourceFood and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
International immunopharmacology.Int Immunopharmacol.2013 Oct;17(2):373-82. doi: 10.1016/j.intimp.2013.06.024. Epub 2013 Jul 7.
Previously we showed that orally administered Lactobacillus rhamnosus CRL1505 beneficially regulated the balance between pro- and anti-inflammatory mediators in the lungs of poly(I:C)-challenged mice, allowing an effective inflammatory response against the TLR3/RIG-I agonist but at the same time red
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