retinene

　

WordNet

1. either of two yellow to red retinal pigments formed from rhodopsin by the action of light (同)retinal

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/05 18:04:01」(JST)

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The Retinenes (Retinene₁ and Retinene₂) are chemical derivatives of the dietary supplement vitamin A (see retinol) formed through oxidation reactions.

Retinene₁ is better known as retinaldehyde or simply retinal and is fundamental in the transduction of light into visual signals in the photoreceptor level of the retina (known as the visual cycle). Retinene₂ is more formally known as dehydroretinaldehyde.

The energy of impinging photons will convert retinaldehyde from an 11-cis isomer into an all-trans form. In the retina, this conversion induces a conformational change in the surrounding photopsin protein pigment, leading to signaling through the G protein transducin. Retinaldehyde also forms a part of bacteriorhodopsin, a light-induced proton pump found in some archaea.

Experimentally, it is possible to replace 11-cis retinaldehyde by perfusing retinal tissue preparations with retinaldehyde derivatives. Selective modification of the retinaldehyde structure, particularly the density of electrons in the π-orbitals, can lead to insights into the interaction between the retinaldehyde moiety and the surrounding pigment protein.

"The names of all these molecules have recently been changed ... vitamin A is now retinol, retinene is retinal; there is also retinoic acid"—George Wald (1967).

See also

• Visual cycle

References

English Journal

• Cutting Edge: Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase in Lung CD103+ but Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T cells and Promote Airway Tolerance.

• Khare A, Krishnamoorthy N, Oriss TB, Fei M, Ray P, Ray A.SourceDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 Jun 3. [Epub ahead of print]
• Dendritic cell (DC)-T cell interactions that underlie inducible/adaptive regulatory T cell generation and airway tolerance are not well understood. In this study, we show that mice lacking CD11chi lung DCs, but containing plasmacytoid DCs (pDCs), fail tolerization with inhaled Ag and cannot support
• PMID 23733880

• Role of plasmacytoid dendritic cell subsets in allergic asthma.

• Maazi H, Lam J, Lombardi V, Akbari O.SourceDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
• Allergy.Allergy.2013 Jun;68(6):695-701. doi: 10.1111/all.12166. Epub 2013 May 11.
• Plasmacytoid dendritic cells (pDCs) are major type-I interferon-producing cells that play important roles in antiviral immunity and tolerance induction. These cells share a common DC progenitor with conventional DCs, and Fms-like tyrosine kinase-3 ligand is essential for their development. Several s
• PMID 23662841

• Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme.

• Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J.SourceDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
• Archives of biochemistry and biophysics.Arch Biochem Biophys.2013 May 29. pii: S0003-9861(13)00158-6. doi: 10.1016/j.abb.2013.05.007. [Epub ahead of print]
• The formal first step in in vitamin A metabolism is the conversion of its natural precursor β,β-carotene (C40) to retinaldehyde (C20) This reaction is catalyzed by the enzyme β,β-carotene-15,15'-monooxygenase (BCMO1). BCMO1 has been cloned from several vertebrate species, including humans. Howev
• PMID 23727499

Japanese Journal

• ロドプシンにおけるオプシンとレチナールの相互作用 : トリプトファン残基とレチナールの結合について

• 大阪教育大学紀要. III, 自然科学 20, 149-156, 1971
• NAID 110004094143

• Electronmicroscopic Demonstration of Alcohol Dehydrogenase Activity in the Frog Retina

• Proceedings of the Japanese Histochemical Association 1965(6), 47-51, 1965
• NAID 130003826966

• ロドプシン照射時の電導度変化経過の解析

• 動物学雑誌 73(1), 7-11, 1964-01-15
• NAID 110003332702

Related Links

• Retinene | Define Retinene at Dictionary.com

World English Dictionary retina (ˈrɛtɪnə) —n, pl-nas, -nae the light-sensitive membrane forming the inner lining of the posterior wall of the eyeball, composed largely of a specialized terminal expansion of the optic nerve. Images ...

• retinene - Definition of retinene

retinene [ret′'n ēn′] noun Biochem. retinal Origin: retin(a) + -ene Search Webster's New World College Dictionary Webster's New World College Dictionary Copyright © 2010 by Wiley Publishing, Inc., Cleveland, Ohio. Used ...

Related Pictures

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★リンクテーブル★

リンク元

「レチナール」

「レチナール」

　　[★]

英

retinal

同

ビタミンA1アルデヒド vitamin A1 aldehyde、レチネン retinene

関

ビタミンA、網膜