レチナール脱水素酵素、レチナールデヒドロゲナーゼ
WordNet
- in or relating to the retina of the eye; "retinal cells"
- the innermost light-sensitive membrane covering the back wall of the eyeball; it is continuous with the optic nerve
PrepTutorEJDIC
- (目の)網膜
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/29 17:03:08」(JST)
[Wiki en表示]
retinal dehydrogenase |
retinal dehydrogenase inhibited by Yb
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Identifiers |
EC number |
1.2.1.36 |
CAS number |
37250-99-0 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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In enzymology, a retinal dehydrogenase (EC 1.2.1.36) is an enzyme that catalyzes the chemical reaction
- retinal + NAD+ + H2O retinoic acid + NADH + H+
The 3 substrates of this enzyme are retinal, NAD+, and H2O, whereas its 3 products are retinoic acid, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is retinal:NAD+ oxidoreductase. This enzyme is also called cytosolic retinal dehydrogenase. This enzyme participates in retinol metabolism. It has 2 cofactors: FAD, and Metal.
References
- Moffa DJ, Lotspeich FJ, Krause RF (1970). "Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa". J. Biol. Chem. 245 (2): 439–47. PMID 4312676.
Aldehyde/oxo oxidoreductases (EC 1.2)
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1.2.1: NAD or NADP |
- Aldehyde dehydrogenase
- Acetaldehyde dehydrogenase
- Long-chain-aldehyde dehydrogenase
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1.2.2: cytochrome |
- Formate dehydrogenase (cytochrome)
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1.2.3: oxygen |
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1.2.4: disulfide |
- Oxoglutarate dehydrogenase complex
- Pyruvate dehydrogenase
- Branched-chain alpha-keto acid dehydrogenase complex
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1.2.7: iron-sulfur protein |
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Enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Reverse phase protein arrays for the identification/validation of biomarkers of beef texture and their use for early classification of carcasses.
- Gagaoua M1, Bonnet M2, Ellies-Oury MP2, De Koning L3, Picard B2.
- Food chemistry.Food Chem.2018 Jun 1;250:245-252. doi: 10.1016/j.foodchem.2018.01.070. Epub 2018 Jan 10.
- PMID 29412918
- Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in mice.
- Belyaeva OV1, Wu L1, Shmarakov I2, Nelson PS3,4, Kedishvili NY5.
- The Journal of biological chemistry.J Biol Chem.2018 May 4;293(18):6996-7007. doi: 10.1074/jbc.RA117.001646. Epub 2018 Mar 22.
- PMID 29567832
- Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration.
- Parmar T1, Parmar VM1, Perusek L1, Georges A2, Takahashi M2, Crabb JW3, Maeda A4,2,5.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2018 May 1;200(9):3128-3141. doi: 10.4049/jimmunol.1701573. Epub 2018 Mar 30.
- PMID 29602770
Japanese Journal
- Eradication of Hepatitis C Virus Subgenomic Replicon by Interferon Results in Aberrant Retinol-Related Protein Expression
- Koike Kazuko,Takaki Akinobu,Kato Nobuyuki,Ouchida Mamoru,Kanzaki Hirotaka,Yasunaka Tetsuya,Shiraha Hidenori,Miyake Yasuhiro,Yamamoto Kazuhide
- Acta Medica Okayama 66(6), 461-468, 2012-12-00
- … Replicon-harboring cells showed higher expression of retinal dehydrogenase 1 (RALDH-1), which converts retinol to retinoic acid, and the cured cells showed higher expression of retinol-binding protein (RBP), which transports retinol from the liver to target tissues. …
- NAID 120005082623
- 腸管におけるレチノイン酸産生樹状細胞とリンパ球の動態
Related Links
- Definition of retinal dehydrogenase in the Medical Dictionary. retinal dehydrogenase explanation. Information about retinal dehydrogenase in Free online English dictionary. What is retinal dehydrogenase? Meaning of retinal ? ...
- Definition of retinaldehyde dehydrogenase in the Medical Dictionary. retinaldehyde dehydrogenase explanation. Information about retinaldehyde dehydrogenase in Free online English dictionary. What is retinaldehyde ...
★リンクテーブル★
[★]
- 英
- retinal dehydrogenase
- 関
- レチナールデヒドロゲナーゼ
[★]
- 英
- retinal dehydrogenase
- 関
- レチナール脱水素酵素
[★]
- 関
- 11-cis-retinal、retina、retinae、retinaldehyde, retinol
[★]
脱水素酵素 デヒドロゲナーゼ
[★]
脱水素酵素 デヒドロゲナーゼ