WordNet
- the presence of abnormally high levels of sugar in the urine
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- 腎臓の
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/03/09 18:55:11」(JST)
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Renal glycosuria |
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Glucose |
Classification and external resources |
Specialty |
endocrinology |
ICD-10 |
E74.8 |
ICD-9-CM |
271.4 |
OMIM |
233100 |
DiseasesDB |
29130 |
eMedicine |
ped/1991 |
MeSH |
D006030 |
[edit on Wikidata]
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Renal glycosuria, also known as renal glucosuria, is a rare condition in which the simple sugar glucose is excreted in the urine[1] despite normal or low blood glucose levels. With normal kidney (renal) function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood. However, in those with renal glycosuria, glucose is abnormally elevated in the urine due to improper functioning of the renal tubules, which are primary components of nephrons, the filtering units of the kidneys.
Contents
- 1 Diagnosis
- 2 Presentation
- 3 Genetics
- 4 Synonyms
- 5 See also
- 6 References
Diagnosis
A doctor normally can diagnose renal glycosuria when a routine urine test (Urinalysis) detects glucose in the urine, while a blood test indicates that the blood glucose level is normal.
Presentation
In most affected individuals, the condition causes no apparent symptoms (asymptomatic) or serious effects. When renal glycosuria occurs as an isolated finding with otherwise normal kidney function, the condition is thought to be inherited as an autosomal recessive trait[citation needed].
Genetics
It is associated with SLC5A2, coding the sodium-glucose cotransporter 2.
Synonyms
- Benign glycosuria
- Familial renal glycosuria
- Nondiabetic glycosuria
- Primary renal glycosuria
- Diabetes renalis
- Renal diabetes
- Diabetes innocence
- Low renal threshold
See also
- Glycosuria
- Sodium-glucose transport proteins
References
- ^ KHACHADURIAN AK, KHACHADURIAN LA (June 1964). "THE INHERITANCE OF RENAL GLYCOSURIA". Am. J. Hum. Genet. 16: 189–94. PMC 1932305. PMID 14174800.
Inborn error of carbohydrate metabolism: monosaccharide metabolism disorders (including glycogen storage diseases) (E73–E74, 271)
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Sucrose, transport
(extracellular) |
Disaccharide catabolism |
- Congenital alactasia
- Sucrose intolerance
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Monosaccharide transport |
- Glucose-galactose malabsorption
- Inborn errors of renal tubular transport (Renal glycosuria)
- Fructose malabsorption
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Hexose → glucose |
Monosaccharide catabolism |
fructose: |
- Essential fructosuria
- Fructose intolerance
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galactose/galactosemia: |
- GALK deficiency
- GALT deficiency/GALE deficiency
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Glucose ⇄ glycogen |
Glycogenesis |
- GSD type 0, glycogen synthase
- GSD type IV, Andersen's, branching
- Adult polyglucosan body disease
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Glycogenolysis |
extralysosomal: |
- GSD type V, McArdle, muscle glycogen phosphorylase/GSD type VI, Hers', liver glycogen phosphorylase
- GSD type III, Cori's, debranching
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- lysosomal/LSD: GSD type II, Pompe's, glucosidase
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Glucose ⇄ CAC |
Glycolysis |
- MODY 2/HHF3
- GSD type VII, Tarui's, phosphofructokinase
- Triosephosphate isomerase deficiency
- Pyruvate kinase deficiency
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Gluconeogenesis |
- PCD
- Fructose bisphosphatase deficiency
- GSD type I, von Gierke, glucose 6-phosphatase
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Pentose phosphate pathway |
- Glucose-6-phosphate dehydrogenase deficiency
- Transaldolase deficiency
- 6-phosphogluconate dehydrogenase deficiency
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Other |
- Hyperoxaluria
- Pentosuria
- Aldolase A deficiency
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Genetic disorder, membrane: Solute carrier disorders
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1-10 |
- SLC1A3
- SLC2A1
- SLC2A5
- SLC2A10
- Arterial tortuosity syndrome
- SLC3A1
- SLC4A1
- Hereditary spherocytosis 4/Hereditary elliptocytosis 4
- SLC4A11
- Congenital endothelial dystrophy type 2
- Fuchs' dystrophy 4
- SLC5A1
- Glucose-galactose malabsorption
- SLC5A2
- SLC5A5
- Thyroid dyshormonogenesis type 1
- SLC6A19
- SLC7A7
- Lysinuric protein intolerance
- SLC7A9
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11-20 |
- SLC11A1
- SLC12A3
- SLC16A1
- SLC16A2
- Allan–Herndon–Dudley syndrome
- SLC17A5
- SLC17A8
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21-40 |
- SLC26A2
- Multiple epiphyseal dysplasia 4
- Achondrogenesis type 1B
- Recessive multiple epiphyseal dysplasia
- Atelosteogenesis, type II
- Diastrophic dysplasia
- SLC26A4
- SLC35C1
- SLC39A4
- Acrodermatitis enteropathica
- SLC40A1
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see also solute carrier family
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UpToDate Contents
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English Journal
- Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion.
- Troyanov S1, Delmas-Frenette C2, Bollée G3, Youhanna S4, Bruat V5, Awadalla P5, Devuyst O6, Madore F2.
- Clinical journal of the American Society of Nephrology : CJASN.Clin J Am Soc Nephrol.2016 Jan 7;11(1):62-9. doi: 10.2215/CJN.04770415. Epub 2015 Dec 18.
- BACKGROUND AND OBJECTIVES: The urinary excretion of uromodulin is influenced by common variants in the UMOD gene, and it may be related to NaCl retention and hypertension. Levels of uromodulin are also dependent of the renal function, but other determinants remain unknown.DESIGN, SETTING, PARTICIPAN
- PMID 26683887
- Prevalence and significance of proximal renal tubular abnormalities in HIV-infected patients receiving tenofovir.
- Casado JL1, Bañón S, Santiuste C, Serna J, Guzman P, Tenorio M, Liaño F, Rey JM.
- AIDS (London, England).AIDS.2016 Jan;30(2):231-9. doi: 10.1097/QAD.0000000000000901.
- OBJECTIVES: Patients receiving tenofovir, disoproxil, fumarate (TDF) had an increased prevalence of proximal renal tubular dysfunction (PRTD), but contributing factors and its clinical significance remain controversial.DESIGN AND METHODS: Cross-sectional evaluation of different urinary parameters (p
- PMID 26684820
Japanese Journal
- 尿糖排泄閾値低下によるHbA1c値の低下が示唆された境界型糖尿病の2症例
- 大野 洋介,信原 敬子,日向 崇,小寺 力,高橋 行広,伊藤 利光,安田 浩子
- 糖尿病 56(11), 868-873, 2013
- 糖尿病外来受診患者でHbA1c(NGSP値)は基準範囲(5.4~5.5 %)だが,尿糖陽性や空腹時高血糖を認める2症例(症例1,2)について,その病態を検討する目的で75 g経口ブドウ糖負荷試験(OGTT)を実施した.2症例共に,血糖曲線は境界型糖尿病,インスリン分泌能は初期分泌が低下(インスリン分泌指数は0.18~0.25),追加分泌は120分に分泌のピークがあり,相対的なインスリン分泌不足を認 …
- NAID 130004905373
- 宇都宮 靖,佐野 仁志,大谷 英之,戸川 雅美,田村 明子,常井 幹生,星加 忠孝,林 篤
- 日本小児腎臓病学会雑誌 = Japanese journal of pediatric nephrology 20(1), 31-34, 2007-04-15
- 症例は14歳,女児。ぶどう膜炎を発症。初診時血清Crと尿中β2MG値の上昇,ならびに尿糖,白血球尿,尿濃縮力障害を認めた。腎生検では糸球体の形態に異常はみられなかったが間質への著明な単核球浸潤があり,急性間質性腎炎の像を呈していた。本人ならびに家族とのインフォームドコンセントの結果,ステロイドの全身投与を行わず無治療で経過観察としたところ,血清Cr値と尿中β2MG値は徐々に低下し8ヵ月後にはほぼ …
- NAID 10025700961
Related Links
- Renal glycosuria is a rare condition in which the simple sugar glucose is excreted in the urine despite normal or low blood glucose levels. With normal kidney function, glucose is excreted in the urine only when there are ...
- glycosuria /gly·cos·uria/ (su´re-ah) the presence of glucose in the urine. renal glycosuria that due to inherited inability of the renal tubules to reabsorb glucose completely. renal glycosuria n. Recurring or persistent glycosuria with ...
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腎性糖尿
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- renal glycosuria
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- 英
- renal glycosuria
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- 糖尿
[★]
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- kidney、renally