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Radionuclide ventriculography, a type of cardiac ventriculography, is a form of nuclear imaging, where a gamma camera is used to create an image following injection of radioactive material, usually Technetium-99m (^99mTc) labeled red blood cells. In radionuclide ventriculography, the radionuclide has the property of circulating through the cardiac chambers, availing for studies of the pumping function of the heart.^[1] In contrast, in myocardial perfusion imaging, the radionuclide is taken up by the myocardial cells, making its presence correlating with myocardial perfusion or viability of the cells.^[1]

Radionuclide ventriculography is done to evaluate coronary artery disease (CAD), valvular heart disease, congenital heart diseases, cardiomyopathy, and other cardiac disorders.^[1] It exposes patients to less radiation than do comparable chest x-ray studies. However, the radioactive material is retained in the patient for several days after the test, during which sophisticated radiation alarms may be triggered, such as in airports.^[1] Radionuclide ventriculography has largely been replaced by echocardiography, which is less expensive, and does not require radiation exposure. Radionuclide ventriculography gives a much more precise measurement of left ventricular ejection fraction (LVEF) than a transthoracic echocardiogram (TTE). Transthoracic echocardiogram is highly operator dependant, therefore radionuclide ventriculography is a more reproducible measurement of LVEF. Its primary use today is in monitoring cardiac function in patients receiving certain chemotherapeutic agents (anthracyclines: doxorubicin or daunorubicin) which are cardiotoxic. The chemotherapy dose is often determined by the patient's cardiac function. In this setting, a much more accurate measurement of ejection fraction, than a transthoracic echocardiogram can provide, is necessary.^[1]

References

^ ^a ^b ^c ^d ^e Merck manuals > Radionuclide Imaging Last full review/revision May 2009 by Michael J. Shea, MD. Content last modified May 2009

Cardiac ventriculography

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English Journal

Technologist Corner: Value of radionuclide ventriculography to assess mechanical dyssynchrony and predict the cardiac resynchronization therapy response.

Pagnanelli R1, Fudim M2, Borges-Neto S3,2.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.J Nucl Cardiol.2016 Jun;23(3):491-2. doi: 10.1007/s12350-016-0466-7. Epub 2016 Mar 25.
PMID 27016108

Evaluation and management of chemotherapy-induced cardiotoxicity in breast cancer: a Delphi study.

Gavila J1, Seguí MÁ2, Calvo L3, López T4, Alonso JJ5, Farto M6, Sánchez-de la Rosa R6.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.Clin Transl Oncol.2016 Apr 21. [Epub ahead of print]
PURPOSE: While much progress has been made in the treatment of breast cancer, cardiac complications resulting from therapy remain a significant concern. Both anthracyclines and novel targeted agents can inflict cardiac damage. The present study aimed to evaluate the difference between what it is cur
PMID 27101413

Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension.

Lewis GD1, Ngo D2, Hemnes AR3, Farrell L4, Domos C4, Pappagianopoulos PP2, Dhakal BP4, Souza A5, Shi X4, Pugh ME3, Beloiartsev A4, Sinha S4, Clish CB5, Gerszten RE6.
Journal of the American College of Cardiology.J Am Coll Cardiol.2016 Jan 19;67(2):174-89. doi: 10.1016/j.jacc.2015.10.072.
BACKGROUND: Pulmonary hypertension and associated right ventricular (RV) dysfunction are important determinants of morbidity and mortality, which are optimally characterized by invasive hemodynamic measurements.OBJECTIVES: This study sought to determine whether metabolite profiling could identify pl
PMID 26791065

Japanese Journal

診療 64列MDCTにおける両心機能評価についての核医学的検査,X線左室造影法との比較検討 (胸部の最新画像情報2012)

中村政彦
臨床放射線 57(1), 94-103, 2012-01
NAID 40019183875

A Case of Heart Failure with Paroxysmal Atrial Flutter (pAFL) Ameliorated by Successful Radiofrequency Ablation (RFA)—Improvement of Biventricular Dysfunction by Radionuclide Ventriculography

Nakamura Masahiko,Umetani Ken,Aizawa Kazunori
Journal of Arrhythmia 27(Supplement), PJ1_004, 2011
… He was found to have severe biventricular diastolic dysfunction during sinus rhythm by radionuclide ventriculography. … No relevant changes were noticed for ventricular rate, and left ventricular (LV) ejection fraction (EF) (changed from 64% to 68%), whereas, right ventricular (RV) EF improved from 42% to 49% during sinus rhythm before and after the RFA by radionuclide ventriculography. …
NAID 130002130514

Complete Elimination of Cardiodepressant IgG3 Autoantibodies by Immunoadsorption in Patients With Severe Heart Failure

BABA Akiyasu,AKAISHI Makoto,SHIMADA Megumi,MONKAWA Toshiaki,WAKABAYASHI Yasuhisa,TAKAHASHI Michiko,NAGATOMO Yuji,YOSHIKAWA Tsutomu
Circulation journal : official journal of the Japanese Circulation Society 74(7), 1372-1378, 2010-06-25
… All patients had anti-β1-adrenergic and/or M2-muscarinic autoantibodies before IA, and all LVEF were measured on radionuclide ventriculography. …
NAID 10030695502