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- vaccinia virus
WordNet
- a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
- (virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
- a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
PrepTutorEJDIC
- ビールス,ろ過性病原体
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/05 22:52:42」(JST)
[Wiki en表示]
Rabbitpox is a disease of rabbits caused by a virus of the genus Orthopoxvirus and the family Poxviridae.[1] Rabbitpox was first isolated at the Rockefeller Institute in New York in 1933, following a series of epidemics in the laboratory rabbits.[2] It is an acute disease only known to infect laboratory rabbits as no cases have been reported in wild rabbits; it also cannot infect humans.[3]
Contents
- 1 History
- 2 Symptoms
- 3 Infection
- 4 Danger to humans
- 5 References
History
Rabbitpox has not been recognised in wild rabbits, however a few outbreaks have been reported in the USA since 1930.[4]
Symptoms
- Pox lesions may or may not be present on the skin.
- Most rabbits develop a fever and nasal discharge.
- The mortality varies but is always high.
- The most characteristic lesions seen at necropsy are a skin rash, subcutaneous edema, and edema of the mouth and other body openings.
Infection
Rabbitpox virus is a highly infectious airborne agent, which spreads very rapidly through laboratories which contain rabbits causing a high rate of mortality. Because of the edematous condition, “poxless” rabbitpox may be confused with myxomatosis. The virus may be isolated or the infection diagnosed serologically by methods appropriate to vaccinia. Spread through a rabbitry is rapid, but rabbits inoculated with smallpox vaccine are immune.
Rabbitpox virus is closely related immunologically to vaccinia virus, consequently rabbits that have been inoculated with the smallpox (vaccinia virus) vaccine have immunity against rabbitpox.
Danger to humans
Rabbitpox virus does not infect humans.
References
- ^ "Medical Dictionary - 'rabbitpox virus'". mediLexicon. Retrieved 2007-04-03.
- ^ C. Upton; Chen, N; Roper, RL; Feng, Z; Hunter, A; Danila, M; Lefkowitz, EJ; Buller, RM; Upton, C (August 12, 2005). "Complete coding sequences of the rabbitpox virus genome" (PDF). Journal of General Virology 86 (Pt 11): 2969–2977. doi:10.1099/vir.0.81331-0. PMID 16227218. Retrieved 2007-04-03.
- ^ "Rabbitpox". The Merck Veterinary Manual. Retrieved 2007-04-03.
- ^ Merck Veterinary Manual
UpToDate Contents
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English Journal
- Integration of linear and dendritic actin nucleation in Nck-induced actin comets.
- Borinskaya S1, Velle KB2, Campellone KG2, Talman A3, Alvarez D4, Agaisse H3, Wu YI5, Loew LM6, Mayer BJ7.
- Molecular biology of the cell.Mol Biol Cell.2016 Jan 15;27(2):247-59. doi: 10.1091/mbc.E14-11-1555. Epub 2015 Nov 25.
- The Nck adaptor protein recruits cytosolic effectors such as N-WASP that induce localized actin polymerization. Experimental aggregation of Nck SH3 domains at the membrane induces actin comet tails-dynamic, elongated filamentous actin structures similar to those that drive the movement of microbial
- PMID 26609071
- The acidic C-terminus of vaccinia virus I3 single-strand binding protein promotes proper assembly of DNA-protein complexes.
- Harrison ML1, Desaulniers MA1, Noyce RS1, Evans DH2.
- Virology.Virology.2016 Jan 13;489:212-222. doi: 10.1016/j.virol.2015.12.020. [Epub ahead of print]
- The vaccinia virus I3L gene encodes a single-stranded DNA binding protein (SSB) that is essential for virus DNA replication and is conserved in all Chordopoxviruses. The I3 protein contains a negatively charged C-terminal tail that is a common feature of SSBs. Such acidic tails are critical for SSB-
- PMID 26773382
- Features of the Antitumor Effect of Vaccinia Virus Lister Strain.
- Zonov E1, Kochneva G2, Yunusova A3, Grazhdantseva A4, Richter V5, Ryabchikova E6.
- Viruses.Viruses.2016 Jan 12;8(1). pii: E20.
- Oncolytic abilities of vaccinia virus (VACV) served as a basis for the development of various recombinants for treating cancer; however, "natural" oncolytic properties of the virus are not examined in detail. Our study was conducted to know how the genetically unmodified L-IVP strain of VACV produce
- PMID 26771631
Japanese Journal
- An antigenic difference between intracellular and extracellular rabbitpox virus
Related Links
- Viruses are not important causes of clinical disease of rabbits in the USA but include the infectious fibromas, papillomatosis, rabbitpox, myxomatosis, and a herpesvirus infection (virus 3). Rotaviral enteritis also has been ...
- Rabbitpox Rabbit pox is a rare disease induced by an Orthopoxvirus taxonomically similar to vaccina virus that has caused outbreaks of fatal disease in laboratory rabbits in the United States and Holland (Brabb and Di Giacomo ...
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