ピロリジノン
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- pyrrolidone
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/02 23:48:40」(JST)
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2-Pyrrolidone |
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Identifiers |
CAS number |
616-45-5 Y |
ChemSpider |
11530 Y |
UNII |
KKL5D39EOL Y |
ChEBI |
CHEBI:36592 Y |
ChEMBL |
CHEMBL276849 Y |
Jmol-3D images |
Image 1 |
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InChI=1S/C4H7NO/c6-4-2-1-3-5-4/h1-3H2,(H,5,6) Y
Key: HNJBEVLQSNELDL-UHFFFAOYSA-N Y
InChI=1/C4H7NO/c6-4-2-1-3-5-4/h1-3H2,(H,5,6)
Key: HNJBEVLQSNELDL-UHFFFAOYAP
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Properties |
Molecular formula |
C4H7NO |
Molar mass |
85.10 g mol−1 |
Density |
1.116 g/cm³[1] |
Melting point |
25 °C, 298 K, 77 °F ([2])
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Boiling point |
245 °C, 518 K, 473 °F ([1])
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Hazards |
MSDS |
ScienceLab.com |
NFPA 704 |
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Flash point |
129 °C (264 °F) (open cup)[1]
138 °C (280 °F) (closed cup)[2] |
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
2-Pyrrolidone (2-pyrrolidinone) is an organic compound consisting of a five-membered lactam. It is a colorless liquid used in industrial settings as a high-boiling non-corrosive polar solvent for a wide variety of applications. It is miscible with a wide variety of other solvents including water, ethanol, diethyl ether, chloroform, benzene, ethyl acetate, and carbon disulfide.
2-Pyrrolidone is an intermediate in the manufacture of polymers such as polyvinylpyrrolidone and polypyrrolidone.
A variety of pharmaceutical drugs are 2-pyrrolidone derivatives including:
- Cotinine
- Doxapram
- Piracetam
- Povidone
- Ethosuximide
See also[edit]
- N-Methylpyrrolidone (NMP)
- N-Vinylpyrrolidone (NVP)
References[edit]
- ^ a b c Merck Index, 11th Edition, 8027
- ^ a b Record in the GESTIS Substance Database from the IFA
External links[edit]
- Pyrrolidinones at the US National Library of Medicine Medical Subject Headings (MeSH)
English Journal
- Chiral-Substituted Poly-N-vinylpyrrolidinones and Bimetallic Nanoclusters in Catalytic Asymmetric Oxidation Reactions.
- Hao B1, Gunaratna MJ1, Zhang M1, Weerasekara S1, Seiwald SN1, Nguyen VT1, Meier A1, Hua DH1.
- Journal of the American Chemical Society.J Am Chem Soc.2016 Dec 28;138(51):16839-16848. doi: 10.1021/jacs.6b12113. Epub 2016 Dec 15.
- A new class of poly-N-vinylpyrrolidinones containing an asymmetric center at C5 of the pyrrolidinone ring were synthesized from l-amino acids. The polymers, particularly 17, were used to stabilize nanoclusters such as Pd/Au for the catalytic asymmetric oxidations of 1,3- and 1,2-cycloalkanediols and
- PMID 27976875
- Visible-Light Promoted Distereodivergent Intramolecular Oxyamidation of Alkenes.
- Ren X1, Guo Q1, Chen J1,2, Xie H3, Xu Q2, Lu Z1.
- Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2016 Dec 23;22(52):18695-18699. doi: 10.1002/chem.201603977. Epub 2016 Nov 15.
- The visible-light-promoted diastereodivergent intramolecular oxyamination of alkenes is described to construct oxazolindinones, pyrrolidinones and imidazolidones via mild generation of primary amidyl radicals from functionalized hydroxylamines. A unique phenomenon of highly diastereoselective ring-o
- PMID 27770547
- Secondary Amides as Hydrogen Atom Transfer Promoters for Reactions of Samarium Diiodide.
- Chciuk TV1, Li AM1, Vazquez-Lopez A1, Anderson WR Jr1, Flowers RA 2nd1.
- Organic letters.Org Lett.2016 Dec 21. doi: 10.1021/acs.orglett.6b03664. [Epub ahead of print]
- Two secondary amides (N-methylacetamide and 2-pyrrolidinone) were used as additives with SmI2 in THF to estimate the extent of N-H bond weakening upon coordination. Mechanistic and synthetic studies demonstrate significant bond-weakening, providing a reagent system capable of reducing a range of sub
- PMID 28001419
Japanese Journal
- SYNTHESIS OF NOVEL BENZIMIDAZOLES 2-FUNCTIONALIZED WITH PYRROLIDINONE AND γ-AMINO ACID WITH A HIGH ANTIBACTERIAL ACTIVITY
- Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 92(2), 235-251, 2016-02-01
- NAID 40020796956
- Total Synthesis of Biologically Active Natural Products Based on Highly Selective Synthetic Methodologies
- (<i>S</i>)-ピログルタミン酸誘導体を用いるポリヒドロキシアミン類の立体選択的合成
Related Links
- 1-Methyl-2-pyrrolidinone 別名 (英名) NMP 和名 1-メチル-2-ピロリドン 和名別名 1-メチル-2-ピロリジノン 基本情報 製品コード M0418 化審法:(5)-113:優先評価化学物質 ・川口の在庫は即日,つくばの在庫は2〜3日以内 の出荷となります。 ...
- Sigma-Aldrich offers Aldrich-240338, 2-Pyrrolidinone for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Determination of Water Content in 2-Pyrrolidone Using Karl Fischer ...
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