WordNet

a colorless crystalline organic base containing nitrogen; the parent compound of various biologically important substances
any of several bases that are derivatives of purine
a glycoside formed by partial hydrolysis of a nucleic acid

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1. プリンヌクレオシドホスホリラーゼ欠損症 purine nucleoside phosphorylase deficiency
2. 低尿酸血症：原因および臨床的意義 hypouricemia causes and clinical significance
3. ヌクレオシド系逆転写酵素阻害剤の薬理学 pharmacology of nucleoside reverse transcriptase inhibitors
4. 薬剤および生物学的製剤治療による二次性免疫不全症 secondary immunodeficiency induced by drugs and biologic therapies
5. アデノシンデアミナーゼ欠損症：病因、臨床症状、および診断 adenosine deaminase deficiency pathogenesis clinical manifestations and diagnosis

Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.

Demir Z1, Guven EB2, Ozbey S3, Kazak C4, Atalay RC5, Tuncbilek M6.
European journal of medicinal chemistry.Eur J Med Chem.2015 Jan 7;89:701-20. doi: 10.1016/j.ejmech.2014.10.080. Epub 2014 Oct 30.
Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purines (15-27), 9-(p-toluenesulfonyl/cyclopentyl/ethoxycarbonylmethyl)-6-(substituted amino/piperazino)purines (28-34, 36, 37, 38-41) were synthesized and evaluated initially for their cytotoxic activities o
PMID 25462277

The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer.

Gebremeskel S1, LeVatte T, Liwski RS, Johnston B, Bezuhly M.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jan 1;136(1):234-40. doi: 10.1002/ijc.28947. Epub 2014 May 14.
Tumor cells use activated platelets to promote their proliferation and metastatic potential. Because platelet activation is largely mediated through ADP engagement of purinergic P2Y12 receptors on platelets, we investigated the potential of the reversible P2Y12 inhibitor ticagrelor, a clinical agent
PMID 24798403

Borea PA1, Varani K2, Vincenzi F1, Baraldi PG1, Tabrizi MA1, Merighi S2, Gessi S1.
Pharmacological reviews.Pharmacol Rev.2015 Jan;67(1):74-102. doi: 10.1124/pr.113.008540.
By general consensus, the omnipresent purine nucleoside adenosine is considered a major regulator of local tissue function, especially when energy supply fails to meet cellular energy demand. Adenosine mediation involves activation of a family of four G protein-coupled adenosine receptors (ARs): A(1
PMID 25387804

Watanabe Kimiko,Tomioka Satsuki,Tanimura Kiyoko [他],OKU Hisae,ISOI Koichiro
Bioscience, biotechnology, and biochemistry 75(1), 7-12, 2011-01-23
… purine biosynthesis at a point between IMP and 5-aminoimidazole-4-carboxiamide-1-β-D-ribofuranoside (AICAR), was 1:0.43:0.19. … About 2-fold more radioactive purine bases than purine nucleosides were detected in the cytoplasm after 5 min in an experiment with [8-<SUP>14</SUP>C]AMP and T-1 cells. …
NAID 10027896383

Kanazawa Takashi,Shiba Norio,Aizawa Akira [他],Okuno Haruna,Tamura Kazushi,Tsukada Shota,Kumamoto Tadashi,Yamada Shiro ,Kobayashi Ysuko,Arakawa Hirokazu
北関東医学 61(2), 119-126, 2011
… Background: Nelarabine (NEL) is a new purine nucleoside analogue that has recently become available for both adults and children with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL)and T-lymphoblastic lymphoma (T-LBL). … To study the mechanism of NEL resistance, we originally established a nucleoside an alogue resistant T-ALL Jurkat cell line model (Jurkat+C) induced by incubation in medium containing cytarabine (AraC) at LC,o ofthe control. …
NAID 130000872622