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1. An overview of the innate immune system
2. 成人の肺胞蛋白症の原因、臨床症状、診断 causes clinical manifestations and diagnosis of pulmonary alveolar proteinosis in adults
3. 小児における肺胞蛋白症 pulmonary alveolar proteinosis in children
4. 成人における肺静脈閉塞症の疫学、病因、臨床評価および診断 epidemiology pathogenesis clinical evaluation and diagnosis of pulmonary veno occlusive disease in adults
5. 成人の肺胞タンパク症の治療と予後 treatment and prognosis of pulmonary alveolar proteinosis in adults

In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles.

Lu X1, Miousse IR2, Pirela SV1, Moore JK3, Melnyk S4, Koturbash I2, Demokritou P1.
Nanotoxicology.Nanotoxicology.2016 Jun;10(5):629-39. doi: 10.3109/17435390.2015.1108473. Epub 2015 Nov 11.
Evidence continues to grow on potential environmental health hazards associated with engineered nanomaterials (ENMs). While the geno- and cytotoxic effects of ENMs have been investigated, their potential to target the epigenome remains largely unknown. The aim of this study is two-fold: 1) determini
PMID 26559097

CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-γ⁺ Th1 Cells or Foxp3⁺ Regulatory T Cells in the Lung.

Kim do H1,2, Sohn JH1,2,3, Park HJ1,2, Lee JH3, Park JW4, Choi JM1,5.
Allergy, asthma & immunology research.Allergy Asthma Immunol Res.2016 May;8(3):264-75. doi: 10.4168/aair.2016.8.3.264.
PURPOSE: CpG oligodeoxynucleotide (CpG-ODN), a TLR9 agonist, activates innate immunity and induces Th1 response. Although the immune modulatory effect of CpG-ODN has been extensively studied, its function in cockroach extract-induced allergic asthma has not been studied. Here, we investigated the in
PMID 26922937

Genetic background affects the expansion of macrophage subsets in the lungs of Mycobacterium tuberculosis-infected hosts.

Bertolini TB1, de Souza AI1, Gembre AF1, Piñeros AR1, Prado Rde Q1, Silva JS1, Ramalho LN2, Bonato VL1.
Immunology.Immunology.2016 May;148(1):102-13. doi: 10.1111/imm.12591.
M1 macrophages are more effective in the induction of the inflammatory response and clearance of Mycobacterium tuberculosis than M2 macrophages. Infected C57BL/6 mice generate a stronger cellular immune response compared with BALB/c mice. We hypothesized that infected C57BL/6 mice would exhibit a hi
PMID 26840507

Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems

Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems

The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis