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1. 性転換：疫学、病態生理、および診断 transsexualism epidemiology pathophysiology and diagnosis
2. 性転換治療 treatment of transsexualism
3. 重症熱傷の合併症および長期転帰 complications and long term outcomes of a severe burn
4. 早期副腎皮質性第二次性徴 premature adrenarche
5. 乳癌治療後の患者へのアプローチ approach to the patient following treatment for breast cancer

English Journal

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males.

Lei X1, Chen C2, Xue F3, He Q4, Chen C3, Liu Q3, Moyzis RK5, Xue G6, Cao Z3, Li J3, Li H3, Zhu B3, Liu Y3, Hsu AS7, Li J3, Dong Q8.Author information 1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.2Department of Psychology and Social Behavior, University of California, Irvine, CA, USA. Electronic address: Chuansheng.Chen@uci.edu.3State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.4Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA.5Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA; Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA.6State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA.7Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.8State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. Electronic address: dongqi@bnu.edu.cn.AbstractThe seven-factor biopsychosocial model of personality distinguished four biologically based temperaments and three psychosocially based characters. Previous studies have suggested that the four temperaments-novelty seeking (NS), reward dependence (RD), harm avoidance (HA), and persistence (P)-have their respective neurobiological correlates, especially in the striatum-connected subcortical and cortical networks. However, few studies have investigated their neurobiological basis in the form of fiber connectivity between brain regions. This study correlated temperaments with fiber connectivity between the striatum and subcortical and cortical hub regions in a sample of 50 Chinese adult males. Generally consistent with our hypotheses, results showed that: (1) NS was positively correlated with fiber connectivity from the medial and lateral orbitofrontal cortex (mOFC, lOFC) and amygdala to the striatum; (2) RD was positively correlated with fiber connectivity from the mOFC, posterior cingulate cortex/retrosplenial cortex (PCC), hippocampus, and amygdala to the striatum; (3) HA was positively linked to fiber connectivity from the dorsolateral prefrontal cortex (dlPFC) and PCC to the striatum; and (4) P was positively linked to fiber connectivity from the mOFC to the striatum. These results extended the research on the neurobiological basis of temperaments by identifying their anatomical fiber connectivity correlates within the subcortical-cortical neural networks.
NeuroImage.Neuroimage.2014 Apr 1;89:226-34. doi: 10.1016/j.neuroimage.2013.04.043. Epub 2013 Apr 22.
The seven-factor biopsychosocial model of personality distinguished four biologically based temperaments and three psychosocially based characters. Previous studies have suggested that the four temperaments-novelty seeking (NS), reward dependence (RD), harm avoidance (HA), and persistence (P)-have t
PMID 23618602

Hepatic expression patterns in psychosocially high-stressed pigs suggest mechanisms following allostatic principles.

Oster M1, Muráni E2, Ponsuksili S3, D'Eath RB4, Turner SP5, Evans G6, Thölking L7, Kurt E8, Klont R9, Foury A10, Mormède P11, Wimmers K12.Author information 1Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. Electronic address: oster@fbn-dummerstorf.de.2Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. Electronic address: murani@fbn-dummerstorf.de.3Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. Electronic address: s.wimmers@fbn-dummerstorf.de.4Animal & Veterinary Science Research Group, SRUC, West Mains Road, Edinburgh EH9 3JG, UK. Electronic address: rick.death@sruc.ac.uk.5Animal & Veterinary Science Research Group, SRUC, West Mains Road, Edinburgh EH9 3JG, UK. Electronic address: Simon.Turner@sruc.ac.uk.6PIC UK, 2 Kingston Business Park, Kingston Bagpuize, Oxfordshire OX13 5FE, UK. Electronic address: Gary.Evans@pic.com.7PIC Germany, PIC Deutschland GmbH, Ratsteich 31, 24837 Schleswig, Germany. Electronic address: Ludger.Thoelking@pic.com.8Optimeter, Oyak sitesi 1.kisim 11b blok da:4, Sefakoy, Istanbul, Turkey. Electronic address: esrakurt@hotmail.com.9Vion Food Group, Boseind 10, 5281 RM Boxtel Postbus1, 5280 AA Boxtel, The Netherlands. Electronic address: ronald.klont@vionfood.com.10Université Victor Segalen Bordeaux 2, PsyNuGen, UMR 1286, INRA, 33076 Bordeaux, France. Electronic address: aline.foury@bordeaux.inra.fr.11Université Victor Segalen Bordeaux 2, PsyNuGen, UMR 1286, INRA, 33076 Bordeaux, France. Electronic address: pierre.mormede@toulouse.inra.fr.12Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. Electronic address: wimmers@fbn-dummerstorf.de.AbstractPsychosocial challenges are known to introduce cellular and humoral adaptations in various tissues and organs, including parts of the sympatho-adrenal-medullary system and hypothalamic-pituitary-adrenal axis as well as other peripheral tissue being responsive to cortisol and catecholamines. The liver is of particular interest given its vital roles in maintaining homeostasis and health as well as regulating nutrient utilization and overall metabolism. We aimed to evaluate whether and how response to psychosocial stress is reflected by physiological molecular pathways in liver tissue. A pig mixing experiment was conducted to induce psychosocial stress culminating in skin lesions which reflect the involvement in aggressive behavior and fighting. At 27weeks of age, animals prone to psychosocially low- and high-stress were assigned to mixing groups. Skin lesions were counted before mixing and after slaughter on the carcass. Individual liver samples (n=12) were taken. The isolated RNA was hybridized on Affymetrix GeneChip porcine Genome Arrays. Relative changes of mRNA abundances were estimated via variance analyses. Molecular routes related to tRNA charging, urea cycle, acute phase response, galactose utilization, and steroid receptor signaling were found to be increased in psychosocially high-stressed animals, whereas catecholamine degradation and cholesterol biosynthesis were found to be decreased. In particular, psychosocially high-stressed animals show decreased expression of catechol-O-methyltransferase (COMT) which has been linked to molecular mechanisms regulating aggressiveness and stress response. The expression patterns of high-stressed animals revealed metabolic alterations of key genes related to energy-mobilizing processes at the expense of energy consuming processes. Thus, the coping following psychosocial challenges involves transcriptional alterations in liver tissue which may be summarized with reference to the concept of allostasis, a strategy which is critical for survival.
Physiology & behavior.Physiol Behav.2014 Feb 15. pii: S0031-9384(14)00072-9. doi: 10.1016/j.physbeh.2014.02.014. [Epub ahead of print]
Psychosocial challenges are known to introduce cellular and humoral adaptations in various tissues and organs, including parts of the sympatho-adrenal-medullary system and hypothalamic-pituitary-adrenal axis as well as other peripheral tissue being responsive to cortisol and catecholamines. The live
PMID 24534173

Diurnal cortisol patterns and psychiatric symptoms in pregnancy: Short-term longitudinal study.

O'Connor TG1, Tang W2, Gilchrist MA2, Moynihan JA2, Pressman EK2, Blackmore ER2.Author information 1University of Rochester Medical Center, United States. Electronic address: tom_oconnor@urmc.rochester.edu.2University of Rochester Medical Center, United States.AbstractAlteration in the HPA axis is a robust biomarker of anxiety and depression in adults, but questions remain about this association in pregnancy. We examined the longitudinal links between diurnal cortisol and mood symptoms from self-report questionnaire and diagnostic interview in an ethnically diverse, psychosocially at-risk sample of 101 women at mid-pregnancy and early third trimester. There were modest but significant associations between depression and elevated cortisol, indexed by a decreased morning level and diminished diurnal decline; the effects were strongest for diagnostic data from clinical interview. These effects were independent of socio-demographic factors and sleep disturbance. Associations with anxiety and trauma were generally non-significant. These findings extend prior work by showing that significant mood symptoms in pregnancy are associated with altered diurnal cortisol in pregnancy, which may have implications for maternal and child health.
Biological psychology.Biol Psychol.2014 Feb;96:35-41. doi: 10.1016/j.biopsycho.2013.11.002. Epub 2013 Nov 12.
Alteration in the HPA axis is a robust biomarker of anxiety and depression in adults, but questions remain about this association in pregnancy. We examined the longitudinal links between diurnal cortisol and mood symptoms from self-report questionnaire and diagnostic interview in an ethnically diver
PMID 24239618

Japanese Journal

慢性疾患で精神症状を呈する患者への地域精神科医療モデル事業およびその評価 : 精神看護専門看護師とリエゾン・チームの役割

宇佐美しおり,福嶋好重,野末聖香,岡谷恵子,樋山光教,右田香魚子,平田真一,北里眞弓
熊本大学医学部保健学科紀要 5, 9-18, 2009-02-27
… Furthermore they needed to be supported psychosocially by CNS to prevent worse their symptom. …
NAID 110007027368

親の養育態度に対する子どもの認知と子どもの家族間の情緒的安定や生き方志向との関連 : 大学生への調査を通して

千葉陽子,我部山キヨ子,菅佐和子,金岡緑
母性衛生 49(2), 366-373, 2008-07
本研究は,大学生への無記名式質問紙調査により,親の養育態度に対する子どもの認知と子どもの家族間の情緒的安定や生き方志向との関連を検討し,大学生世代への心理社会的支援や良好な親子関係形成への援助に関する示唆を得ることを目的とした。【研究方法】対象は関西圏都市部2大学の18〜24歳の大学生210名,有効回答は151名(回収率71.9%)。倫理的配慮のうえ,個人的背景因子,サイモンズの養育態度尺度日本語 …
NAID 110006840392

精神障害者から学ぶ保健所, 病院地域リハビリの役割

稲庭(今村) 千弥子,石井ちい子,田村あや子,田中茂,佐藤義弘,高橋英弘,村上節子,太田敦子,佐藤静,杉本博子,佐々木孝喜,佐藤美智子,伊藤善信
病院・地域精神医学 = The Japanese journal of hospital and community psychiatry 39(1), 28-30, 1996-12-25
NAID 10011292688