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English Journal

The Insect Peptide Coprisin Prevents Clostridium difficile-Mediated Acute Inflammation and Mucosal Damage through Selective Antimicrobial Activity.

Kang JK, Hwang JS, Nam HJ, Ahn KJ, Seok H, Kim SK, Yun EY, Pothoulakis C, Lamont JT, Kim H.SourceDepartment of Life Science, College of Natural Science, Daejin University, Pocheon, Gyeonggido, South Korea. hokim@daejin.ac.kr.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2011 Oct;55(10):4850-7. Epub 2011 Aug 1.
Clostridium difficile-associated diarrhea and pseudomembranous colitis are typically treated with vancomycin or metronidazole, but recent increases in relapse incidence and the emergence of drug-resistant strains of C. difficile indicate the need for new antibiotics. We previously isolated coprisin,
PMID 21807975

Emergency colectomy for fulminant Clostridium difficile colitis: Striking the right balance.

Osman KA, Ahmed MH, Hamad MA, Mathur D.SourceDepartment of Surgery , The James Cook University Hospital, Middlesbrough , UK.
Scandinavian journal of gastroenterology.Scand J Gastroenterol.2011 Oct;46(10):1222-7. Epub 2011 Aug 15.
Abstract The number of reported cases of Clostridium difficile (CD) infections has increased markedly worldwide. CD causes a spectrum of clinical syndromes, ranging from mild diarrhea to a very severe illness in the form of pseudomembranous colitis (PMC), toxic megacolon, leading to colonic perforat
PMID 21843039