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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/23 22:02:52」(JST)

Proxyphylline is a xanthine derivative that acts as a cardiac stimulant, vasodilator and bronchodilator.^[1]

References

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Borowiecki P1, Paprocki D1, Dudzik A2, Plenkiewicz J1.
The Journal of organic chemistry.J Org Chem.2016 Jan 15;81(2):380-95. doi: 10.1021/acs.joc.5b01840. Epub 2016 Jan 6.
A novel synthetic route for preparation of proxyphylline enantiomers using a kinetic resolution (KR) procedure as the key step is presented. The reactions were catalyzed by immobilized Candida antarctica lipase B in acetonitrile. Three types of reactions were examined: (i) enantioselective transeste
PMID 26517306

Bossé Y1.
The Journal of endocrinology.J Endocrinol.2014 Aug;222(2):R61-73. doi: 10.1530/JOE-14-0220. Epub 2014 Jun 13.
Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated activation of the smooth muscle surrounding the airways, as well as a propensity of the airways to narrow excessively
PMID 24928940

Evaluation of postmortem redistribution phenomena for commonly encountered drugs.

Han E1, Kim E, Hong H, Jeong S, Kim J, In S, Chung H, Lee S.
Forensic science international.Forensic Sci Int.2012 Jun 10;219(1-3):265-71. doi: 10.1016/j.forsciint.2012.01.016. Epub 2012 Jan 30.
We described the findings of a study into the post-mortem redistribution (PMR) of 76 drugs found in 129 drug-related cases between 2006 and 2009. Seventy six drugs (psychotropic drugs (n=14), antidepressants (n=9), sedatives (n=6) and so on) were simultaneously quantified in cardiac and peripheral b
PMID 22284073

Glassy State of Pharmaceuticals. V. Relaxation during Cooling and Heating of Glass by Differential Scanning Calorimetry

福岡英平,牧田みどり,中村泰生
Chemical & pharmaceutical bulletin 39(8), 2087-2090, 1991-08-25
… Glass formation was newly discovered for 24 pharmaceuticals including acetaminophen, chloramphenicol, flufenamic acid and proxyphylline. …
NAID 110003629501

榊原仁作 [他],植田泰誠,大崎勉,竹谷和視,安藤佐和子
藥學雜誌 105(8), 730-735, 1985-08-25
… Xanthine derivatives, such as caffeine, theobromine, 7-ethyltheophylline, 7-allyltheophylline, proxyphylline, and diprophylline were allowed to react with hydrazine hydrate to give 1-aminoxanthines and the following biological testings were carried out : (a) phosphodiesterase inhibition (b) activities on guinea-pig papillary muscle (c) activities on guinea-pig atrium (d) activities on guineapig tracheal muscle. …
NAID 110003649664

Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites

リンク元	「プロキシフィリン」

Proxyphylline
Names
	IUPAC name 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione
Identifiers
CAS Number	603-00-9
ChEMBL	ChEMBL37390
Jmol interactive 3D	Image
PubChem	4977
UNII	13G1DMN4P0
	SMILES CC(CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O ;
Properties
Chemical formula	C10H14N4O3
Molar mass	238.24316
Pharmacology
ATC code	R03DA03
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references