プロトポルフィリノーゲンオキシダーゼ PPO
WordNet
- any of the enzymes that catalyze biological oxidation
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/02 17:35:48」(JST)
[Wiki en表示]
| protoporphyrinogen oxidase |
| Identifiers |
| EC number |
1.3.3.4 |
| CAS number |
53986-32-6 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
| protoporphyrinogen oxidase |
| Identifiers |
| Symbol |
PPOX |
| Alt. symbols |
VP |
| Entrez |
5498 |
| HUGO |
9280 |
| OMIM |
600923 |
| RefSeq |
NM_000309 |
| UniProt |
P50336 |
| Other data |
| Locus |
Chr. 1 q22 |
Protoporphyrinogen oxidase (EC 1.3.3.4) is an enzyme that is responsible for the seventh step in biosynthesis of protoporphyrin IX. This porphyrin is the precursor to hemoglobin, the oxygen carrier in animals, and chlorophyll, the dye in plants. The enzyme catalyzes the dehydrogenation (removal of hydrogen atoms) of protoporphyrinogen IX (the product of the sixth step in the production of heme) to form protoporphyrin IX. One additional enzyme must modify protoporphyrin IX before it becomes heme. Inhibition of this enzyme is a strategy used in certain herbicides.
Heme synthesis—note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)
See also
- porphyrin
- http://plantandsoil.unl.edu/pages/informationmodule.php?idinformationmodule=939154153&topicorder=3&maxto=8&minto=1
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Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
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| Arrestin |
|
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| Membrane-spanning 4A |
- MS4A1
- MS4A2
- MS4A3
- MS4A4A
- MS4A4E
- MS4A5
- MS4A6A
- MS4A6E
- MS4A7
- MS4A8B
- MS4A9
- MS4A10
- MS4A12
- MS4A13
- MS4A14
- MS4A15
- MS4A18
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| Myelin |
- Myelin basic protein
- Myelin proteolipid protein
- Myelin oligodendrocyte glycoprotein
- Myelin-associated glycoprotein
- Myelin protein zero
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| Pulmonary surfactant |
- Pulmonary surfactant-associated protein B
- Pulmonary surfactant-associated protein C
|
|
| Tetraspanin |
- TSPAN1
- TSPAN2
- TSPAN3
- TSPAN4
- TSPAN5
- TSPAN6
- TSPAN7
- TSPAN8
- TSPAN9
- TSPAN10
- TSPAN11
- TSPAN12
- TSPAN13
- TSPAN14
- TSPAN15
- TSPAN16
- TSPAN17
- TSPAN18
- TSPAN19
- TSPAN20
- TSPAN21
- TSPAN22
- TSPAN23
- TSPAN24
- TSPAN25
- TSPAN26
- TSPAN27
- TSPAN28
- TSPAN29
- TSPAN30
- TSPAN31
- TSPAN32
- TSPAN33
- TSPAN34
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| Other/ungrouped |
- Calnexin
- LDL-receptor-related protein-associated protein
- Neurofibromin 2
- Presenilin
- HFE
- Phospholipid transfer proteins
- Dysferlin
- STRC
- OTOF
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see also other cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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Oxidoreductases: CH–CH oxidoreductases (EC 1.3)
|
|
| 1.3.1: NAD/NADP acceptor |
- Enoyl-acyl carrier protein reductase/Enoyl ACP reductase
- 7-Dehydrocholesterol reductase
- Biliverdin reductase
- 2,4 Dienoyl-CoA reductase
|
|
| 1.3.3: Oxygen acceptor |
- Dihydroorotate dehydrogenase
- Coproporphyrinogen III oxidase
- Protoporphyrinogen oxidase
|
|
| 1.3.5: Quinone |
|
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| 1.3.99: Other acceptors |
- Fumarate reductase
- Butyryl CoA dehydrogenase
- Acyl CoA dehydrogenase
- 5α-reductase
- Glutaryl-CoA dehydrogenase
- Isovaleryl coenzyme A dehydrogenase
|
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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- Metabolism: amino acid metabolism
- porphyrin/heme enzymes
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| Porphyrin biosynthesis |
| early mitochondrial: |
- Aminolevulinic acid synthase
- Porphobilinogen synthase
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| cytosolic: |
- Porphobilinogen deaminase
- Uroporphyrinogen III synthase
- Uroporphyrinogen III decarboxylase
- Coproporphyrinogen III oxidase
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| late mitochondrial: |
- Protoporphyrinogen oxidase
- Ferrochelatase
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Heme degradation
to bile |
| spleen: |
- Heme oxygenase
- Biliverdin reductase
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| liver: |
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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UpToDate Contents
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English Journal
- Comparative toxicity of twenty herbicides to five periphytic algae and the relationship with mode of action.
- Nagai T1, Taya K1, Yoda I1.
- Environmental toxicology and chemistry / SETAC.Environ Toxicol Chem.2015 Jul 14. doi: 10.1002/etc.3150. [Epub ahead of print]
- We used 5 species periphytic algae to conduct toxicity assays of twenty herbicides. The 5 tested species represent riverine primary producers most likely to be affected by herbicides. A fluorescence microplate toxicity assay was used as an efficient and economical high-throughput assay. Toxicity cha
- PMID 26174500
- Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition.
- Sanyal N1, Alam S, Pradhan S, Banerjee K, Chowdhury A, Aktar MW.
- Environmental monitoring and assessment.Environ Monit Assess.2015 Jul;187(7):4345. doi: 10.1007/s10661-015-4345-5. Epub 2015 Jun 16.
- Present investigation was carried out using two commercial products Raft (oxadiargyl 6 % EC) and Topstar (oxadiargyl 80 % WP) of Oxadiargyl {5-tert-butyl-3[2,4-dichloro-5-(prop-2-ynyloxy)phenyl]-1,3,4-oxadiazol-2 (3H)-one} to investigate the persistence behavior and metabolism of the herbicide in
- PMID 26077021
- Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
- Bazzocco S1, Dopeso H1, Carton-Garcia F1, Macaya I1, Andretta E1, Chionh F2, Rodrigues P1, Garrido M3, Alazzouzi H1, Nieto R1, Sanchez A4, Schwartz S Jr5, Bilic J1, Mariadason JM2, Arango D6.
- Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2015 May 5. [Epub ahead of print]
- PURPOSE: The clinical management of colorectal cancer patients has significantly improved because of the identification of novel therapeutic targets such as EGFR and VEGF. Because rapid tumor proliferation is associated with poor patient prognosis, here we characterized the transcriptional signature
- PMID 25944804
Japanese Journal
- 藤田 美幸,川田 暁,中野 創
- 皮膚の科学 13(3), 185-188, 2014
- … 患者末梢血 DNA の遺伝子解析でプロトポルフィリンノーゲン酸化酵素 (protoporphyrinogen oxidase: PPOX) 遺伝子の exon 7 に c.779T＞C の変異を同定し，異型ポルフィリン症 (variegate porphyria: VP) と診断した。 …
- NAID 130004688255
- Molecular basis for the herbicide resistance of protoporphyrinogen oxidase(Resistance,Poster,1) Pest Management, Crop Protection and Vector Control)
- Computational elucidation of mechanistic behaviour of protoporphyrinogen oxidase through molecular simulation and quantum mechanics calculation(Molecular Target & Mode of Action,Poster,1) Pest Management, Crop Protection and Vector Control)
Related Links
- The official name of this gene is “protoporphyrinogen oxidase.” PPOX is the gene's official symbol. The PPOX gene is also known by other names, listed below. Read more about gene names and symbols on the About page.
- forum Join the Word of the Day Mailing List For webmasters TheFreeDictionary Google Bing? Word / Article Starts with Ends with Text ... Acronym Definition PPOX Protoporphyrinogen Oxidase (gene) PPOx Phenacylpyridinium ...
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- 英
- protoporphyrinogen oxidase
- 同
- プロトポルフィリノーゲン酸化酵素
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- 同
- protoporphyrinogen oxidase
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(ヘムやクロロフィル生合成中間体)プロトポルフィリノーゲン