proteinase-activated receptor 1

• プロテアーゼ活性化受容体1

関

PAR-1、PAR-1 receptor、protease-activated receptor 1

WordNet

1. aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
2. make (substances) radioactive
3. make active or more active; "activate an old file"
4. make more adsorptive; "activate a metal"
5. rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
6. (of e.g. a molecule) made reactive or more reactive (同)excited
7. (military) set up and placed on active assignment; "a newly activated unit"
8. (of sewage) treated with aeration and bacteria to aid decomposition
9. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. …'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
2. =sense organ / 受信装置

UpToDate Contents

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• 1. 複合免疫不全 combined immunodeficiencies
• 2. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 3. T細胞受容体シグナル伝達 t cell receptor signaling
• 4. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
• 5. 適応細胞性免疫応答 the adaptive cellular immune response

English Journal

• Proteasome inhibitors exacerbate interleukin-8 production induced by protease-activated receptor 2 in intestinal epithelial cells.

• Ghouzali I1, Azhar S1, Bôle-Feysot C1, Ducrotté P2, Déchelotte P3, Coëffier M4.
• Cytokine.Cytokine.2016 Oct;86:41-6. doi: 10.1016/j.cyto.2016.07.014. Epub 2016 Jul 25.
• Protease activated receptors (PARs) and the ubiquitin-proteasome system (UPS) regulate inflammatory response in intestinal cells. We aimed to elucidate putative connections between PARs and UPS pathways in intestinal epithelial cells. Caco-2 cells were treated by agonist peptides of PARs and/or IL-1
• PMID 27455449

• Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice.

• Waasdorp M1, Duitman J1, Florquin S2, Spek CA1.
• Scientific reports.Sci Rep.2016 Sep 13;6:33030. doi: 10.1038/srep33030.
• Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a protease-activated receptor-1 (PAR-1)-dependent manner, suggesting that PAR-1 activation limits the progression of DN. Activation of PAR-1 in fibroblast-like cells, however, induces proliferation and extracellul
• PMID 27618774

• Coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis.

• Nault R1, Fader KA1, Kopec AK2, Harkema JR3, Zacharewski TR1, Luyendyk JP4.
• Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2016 Sep 9. pii: kfw175. [Epub ahead of print]
• Emerging evidence supports a role for environmental chemical exposure in the pathology of non-alcoholic fatty liver disease (NAFLD), a disease process tightly linked to increased activity of the blood coagulation cascade. Exposure of C57BL/6 mice to the persistent environmental contaminant 2,3,7,8-t
• PMID 27613713

Japanese Journal

• Prostaglandin E₂ Inhibits Proteinase-Activated Receptor 2-Signal Transduction through Regulation of Receptor Internalization

• KOMATSU Hiroyuki,ENJOUJI Shuhei,ITO Akihiro [他]
• The journal of veterinary medical science 75(3), 255-261, 2013-03
• NAID 40019635654

• Contribution of TRPA1 as a Downstream Signal of Proteinase-Activated Receptor-2 to Pancreatic Pain

• Terada Yuka,Fujimura Mayuko,Nishimura Sachiyo [他],Tsubota Maho,Sekiguchi Fumiko,Nishikawa Hiroyuki,Kawabata Atsufumi
• Journal of Pharmacological Sciences 123(3), 284-287, 2013
• … We examined if TRPA1, like TRPV1, contributes to pancreatic nociceptor excitation following proteinase-activated receptor-2 (PAR2) stimulation and to pancreatitis-related pain in mice. …
• NAID 130003382608

• Prostaglandin E2 Inhibits Proteinase-Activated Receptor 2-Signal Transduction through Regulation of Receptor Internalization

• KOMATSU Hiroyuki,ENJOUJI Shuhei,ITO Akihiro,OHAMA Takashi,SATO Koichi
• Journal of Veterinary Medical Science 75(3), 255-261, 2013
• … Proteinase-activated receptor (PAR) is expressed on various cells, and the PAR family consists of PAR1, PAR2, PAR3, and PAR4. … Individual PARs are activated during inflammatory conditions in which they regulate inflammatory responses in various diseases. …
• NAID 130001879641

Related Links

• Proteinase-activated receptors.

1. Pharmacol Rev. 2001 Jun;53(2):245-82. Proteinase-activated receptors. Macfarlane SR(1), Seatter MJ, Kanke T, Hunter GD, Plevin R. Author information: (1)Department of Physiology and Pharmacology, University of ...

• 研究1

Protease activated receptor (PAR) の活性化機構： PARは、蛋白質分解酵素により、その細胞外領域の特定の部位が切断されると。新たに生じたN末端領域が受容体に作用し、活性化される。

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★リンクテーブル★

リンク元	「PAR-1 receptor」「プロテアーゼ活性化受容体1」「PAR-1」「protease-activated receptor 1」
関連記事	「activated」「activate」「proteinases」「proteinase」

「PAR-1 receptor」

　　[★]

• プロテアーゼ活性化受容体1、プロテアーゼ活性化レセプター1、PAR-1受容体、PAR-1レセプター

関

PAR-1、protease-activated receptor 1、proteinase-activated receptor 1

「プロテアーゼ活性化受容体1」

　　[★]

英

protease-activated receptor 1、proteinase-activated receptor 1、PAR-1 receptor、PAR-1

関

PAR-1受容体、プロテアーゼ活性化レセプター1、PAR-1レセプター

「PAR-1」

　　[★]

• プロテアーゼ活性化受容体1

関

PAR-1 receptor、protease-activated receptor 1、proteinase-activated receptor 1

「protease-activated receptor 1」

　　[★]

• プロテアーゼ活性化受容体1

関

PAR-1、PAR-1 receptor、proteinase-activated receptor 1

「activated」

　　[★]

• adj.

• 活性化の、活性化型の、賦活化の

関

activate、activated form、activation、turn on

　 　 　 　

「activate」

　　[★]

• v.

• 活性化する、賦活化する、賦活する

関

activated、activation、turn on

　 　 　 　 　

「proteinases」

　　[★]

関

See Proteases／proteinases

「proteinase」

　　[★]

日

関

同

proteinases