WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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1. プロテインＳ欠乏症 protein s deficiency
2. プロテインＣ欠乏症 protein c deficiency
3. 第V因子ライデンと活性化プロテインC抵抗性 factor v leiden and activated protein c resistance
4. 肥大型心筋症：遺伝子変異および臨床遺伝子検査 hypertrophic cardiomyopathy gene mutations and clinical genetic testing
5. 維持透析患者における蛋白質摂取 protein intake in maintenance hemodialysis patients

High-yield soluble expression, purification and characterization of human steroidogenic acute regulatory protein (StAR) fused to a cleavable Maltose-Binding Protein (MBP).

Sluchanko NN1, Tugaeva KV2, Faletrov YV3, Levitsky DI4.
Protein expression and purification.Protein Expr Purif.2015 Nov 7. pii: S1046-5928(15)30094-2. doi: 10.1016/j.pep.2015.11.002. [Epub ahead of print]
Steroidogenic acute regulatory protein (StAR) is responsible for the rapid delivery of cholesterol to mitochondria where the lipid serves as a source for steroid hormones biosynthesis in adrenals and gonads. Despite many successful investigations, current understanding of the mechanism of StAR actio
PMID 26555181

The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90.

Buckton LK1, Wahyudi H1, McAlpine SR1.
Chemical communications (Cambridge, England).Chem Commun (Camb).2015 Nov 3. [Epub ahead of print]
Sixteen linear and cyclic peptides were designed de novo to target the C-terminus of heat shock protein 90 (Hsp90). Protein binding data indicates that three compounds directly block co-chaperone access to Hsp90's C-terminus and luciferase renaturation assays confirm Hsp90-mediated protein folding i
PMID 26528929

Membrane Composition Influences the Activity of in Vitro Refolded Human Vitamin K Epoxide Reductase.

Jaenecke F1,2, Friedrich-Epler B1, Parthier C1, Stubbs MT1,2.
Biochemistry.Biochemistry.2015 Oct 27;54(42):6454-61. doi: 10.1021/acs.biochem.5b00716. Epub 2015 Oct 9.
Human vitamin K epoxide reductase (hVKOR) is an integral membrane protein responsible for the maintenance of reduced vitamin K pools, a prerequisite for the action of γ-glutamyl carboxylase and hence for hemostasis. Here we describe the recombinant expression of hVKOR as an insoluble fusion protein
PMID 26435421

Integration of PEGylation and refolding for renaturation of recombinant proteins from insoluble aggregates produced in bacteria : Application to a single-chain Fv fragment(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Kumagai Izumi,Asano Ryutaro,Nakanishi Takeshi,Hashikami Kentaro,Tanaka Sho,Badran Adel,Sanada Hideaki,Umetsu Mitsuo
Journal of bioscience and bioengineering 109(5), 447-452, 2010-05
The conjugation of polyethylene glycol (PEGylation) with downsized compact antibodies is an effective method for overcoming the problem of rapid elimination of the compact antibodies from the body. We …
NAID 110007618919