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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/23 01:42:17」(JST)

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Prosultiamine (Alinamin, Binova, Jubedel, Taketron, Thiobeta, Thiotiamina), also known as thiamine propyl disulfide (TPD), is a disulfide thiamine derivative developed in Japan in the 1950s as a treatment for vitamin B₁ deficiency.^[1]^[2] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.^[3]^[4] It is also a potential treatment for HTLV, since it has been shown to reduce viral load and symptoms.^[5]

References

^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
^ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
^ Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine 74 (4): 529–34. doi:10.7326/0003-4819-74-4-529. PMID 5551161.
^ Baker H, Frank O (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology. 22 SUPPL: 63–8. PMID 978282.
^ Nervous System Disease: A New Outlet for an Old Drug?

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English Journal

Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis.

Oka H1, Tsuzuki K, Takebayashi H, Kojima Y, Daimon T, Sakagami M.
Auris, nasus, larynx.Auris Nasus Larynx.2013 Oct;40(5):452-7. doi: 10.1016/j.anl.2012.12.001. Epub 2013 Jan 11.
OBJECTIVE: To address the controversy over whether olfactory function is improved or not after endoscopic sinus surgery (ESS) in patients with eosinophilic (ECRS) and non-eosinophilic chronic rhinosinusitis (non-ECRS).METHODS: Between June 2006 and March 2012, 89 adult patients with CRS underwent ES
PMID 23312885

Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Kira J.
BMC medicine.BMC Med.2013 Aug 15;11:183. doi: 10.1186/1741-7015-11-183.
Prosultiamine, a vitamin B1 derivative, has long been used for beriberi neuropathy and Wernicke's encephalopathy. Based on the finding that prosultiamine induces apoptosis in human T lymphotropic virus type I (HTLV-I)-infected T cells, Nakamura et al. conducted a clinical trial of prosultiamine in p
PMID 23945332

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial.

Nakamura T1, Matsuo T, Fukuda T, Yamato S, Yamaguchi K, Kinoshita I, Matsuzaki T, Nishiura Y, Nagasato K, Narita-Masuda T, Nakamura H, Satoh K, Sasaki H, Sakai H, Kawakami A.
BMC medicine.BMC Med.2013 Aug 15;11:182. doi: 10.1186/1741-7015-11-182.
BACKGROUND: Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several
PMID 23945290

Japanese Journal

Prosultiamine treatment as a new therapeutic strategy in human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis

Clinical and Experimental Neuroimmunology 4(3), 259-260, 2013-12
NAID 120005367573

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial

BMC Medicine 11(1), 182, 2013-08-15
NAID 120005353322

静脈性嗅覚検査・希釈法の有用性に関する検討

日本鼻科学会会誌 51(4), 445-449, 2012
NAID 130004891737

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★リンクテーブル★

リンク元	「プロスルチアミン」

「プロスルチアミン」

Prosultiamine
Systematic (IUPAC) name
	N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(1E)-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Legal status
Legal status	℞ (Prescription only);
Identifiers
CAS Number	59-58-5
ATC code	None
PubChem	CID 5355019
ChemSpider	4511078
UNII	UI32MM3XE3
Chemical data
Formula	C15H24N4O2S2
Molar mass	356.51 g/mol
	SMILES O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C ;

　　[★]

英: prosultiamine, prosulthiamine, thiamine propyl disulfide
商: アリナミン

[isbn3-88763-075-0-1] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.

[isbn0-412-46630-9-2] David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.

[pmid5551161-3] Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine 74 (4): 529–34. doi:10.7326/0003-4819-74-4-529. PMID 5551161.

[pmid978282-4] Baker H, Frank O (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology. 22 SUPPL: 63–8. PMID 978282.

[5] Nervous System Disease: A New Outlet for an Old Drug?

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prosultiamine