WordNet
- a potent substance that acts like a hormone and is found in many bodily tissues (and especially in semen); produced in response to trauma and may affect blood pressure and metabolism and smooth muscle activity
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/21 20:40:20」(JST)
[Wiki en表示]
There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors.[1]
These receptors are named:
- DP1-2 - DP1, DP2 receptors
- EP1-4 - EP1, EP2, EP3, EP4 receptors
- FP - FP
- IP1-2 - IP1, IP2 receptors
- TP - TP receptor
The names of these receptors correspond to the prostaglandin that they bind (e.g., DP1-2 receptors bind to PGD2).
See also[edit]
- Eicosanoid receptor
- Prostaglandin
References[edit]
- ^ Tsuboi K, Sugimoto Y, Ichikawa A (2002). "Prostanoid receptor subtypes". Prostaglandins Other Lipid Mediat. 68-69: 535–56. doi:10.1016/S0090-6980(02)00054-0. PMID 12432942.
External links[edit]
- IUPHAR GPCR Database - Prostanoid receptors
- Prostaglandin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
Membrane proteins, receptors: cell surface receptors
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G protein-coupled receptor |
Class A |
- Eicosanoid receptor (Prostaglandin receptor)
- Protease-activated receptor
- Neurotransmitter receptor
- Purinergic receptor
- Biogenic amine receptor
- Olfactory receptor
|
|
Class B |
|
|
Class C |
- Metabotropic glutamate receptor
|
|
Class D |
|
|
Class E |
|
|
Class F |
|
|
|
Ligand-gated ion channel |
|
|
Enzyme-linked receptor |
- Serine/threonine-specific protein kinase
- Receptor tyrosine kinase
- Guanylate cyclase
|
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Other/ungrouped |
- Asialoglycoprotein receptor
- Tumor necrosis factor receptor
- Immunoglobulin superfamily
- N-Acetylglucosamine receptor
- Neuropilins
- Transferrin receptor
- EDAR
- Lipoprotein receptor-related protein
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- See also
- cell surface receptor deficiencies
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Cell surface receptor: G protein-coupled receptors
|
|
Class A:
Rhodopsin like |
|
|
Class B: Secretin like |
Orphan
|
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
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Other
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- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
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|
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Class C: Metabotropic
glutamate / pheromone |
Taste
|
- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
|
|
Other
|
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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|
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Class F:
Frizzled / Smoothened |
Frizzled
|
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
|
|
Smoothened
|
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Transactivation of EGFR/PI3K/Akt involved in ATP-induced inflammatory protein expression and cell motility.
- Lin CC, Lin WN, Cheng SE, Tung WH, Wang HH, Yang CM.SourceDepartment of Anesthetics, Chang Gung Memorial Hospital and Chang Gung University, Kwei-San, Tao-Yuan, Taiwan.
- Journal of cellular physiology.J Cell Physiol.2012 Apr;227(4):1628-38. doi: 10.1002/jcp.22880.
- Phenotype transition of vascular smooth muscle cells (VSMCs) is important in vascular diseases, such as atherosclerosis and restenosis. Once released, ATP may promote activation of VSMCs by stimulating cyclooxygenase-2 (COX-2), cytosolic phospholipase A(2) (cPLA(2)) expression and prostaglandin (PG)
- PMID 21678415
Japanese Journal
- プロスタグランジンE₂による自然免疫性炎症の抑制 (特集 自然免疫と炎症・自己免疫)
- Prostaglandin E receptor subtype EP4 agonist serves better to protect cochlea than prostaglandin E1.
- Hori Ryusuke,Nakagawa Takayuki,Yamamoto Norio,Hamaguchi Kiyomi,Ito Juichi
- Auris nasus larynx 40(6), 539-542, 2013-12
- … [Objective]The present study aimed to examine whether an E-prostanoid receptor 4 (EP4) agonist has superior protective effects to those of prostaglandin E1 (PGE1) in a guinea pig model of noise trauma. …
- NAID 120005323027
Related Links
- History and name [edit] The name prostaglandin derives from the prostate gland. When prostaglandin was first isolated from seminal fluid in 1935 by the Swedish physiologist Ulf von Euler, [2] and independently by M.W. Goldblatt, [3] it was believed to be part of the prostatic secretions.
- Receptors, Prostaglandin (Prostaglandin Receptors) Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin receptor subtypes have been ...
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